Substrates of multidrug resistance-associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel

British Journal of Pharmacology

Volumn 126, Issue 6, 1999, Pages 1471-1477

  Linsdell, Paul ^a   Hanrahan, John W ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

ABC protein; CFTR; Channel block; Chloride channel; Cystic fibrosis; Multidrug resistance associated protein; Sulphonylurea

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; ESTRADIOL; MULTIDRUG RESISTANCE PROTEIN; TAUROLITHOCHOLIC ACID; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CHLORIDE CURRENT; CHLORIDE TRANSPORT; CONTROLLED STUDY; DISSOCIATION CONSTANT; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

EID: 0033026059     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702458     Document Type: Article

References (33)

1. BEAR, C.E. (1994). Drugs transported by P-glycoprotein inhibit a 40pS outwardly rectifying chloride channel. Biochem. Biophys. Res. Commun., 200, 513-521
2. GADSBY, C. C., NAGEL, G. & HWANG, T.-C. (1995). The CFTR chloride channel of mammalian heart. Annu Rev. Physiol., 57, 387-416.
3. GERLOFF, T., STIEGER, B., HAGENBUCH, B., MADON, J., LANDMANN, L., ROTH, J., HOFMANN, A.F. & MEIER, P.J. (1998). The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J. Biol. Chem., 273, 10046 -10050.
4. HANRAHAN, J.W., KONE, Z., MATTHEWS, C.J., LUO, J., JIA, Y. & LINSDELL, P. (1998). Patch clamp studies of the CFTR chloride channel. Meths. Enzymol., 293, 169-194.
5. HANRAHAN, J.W., TABCHARANI, J.A., BECQ, F., MATHEWS, C.J., AUGUSTINAS, O., JENSEN, T.J., CHANG, X.-B. & RIORDAN, J.R. (1995). Function and dysfunction of the CFTR chloride channel. In Ion Channels and Genetic Diseases. eds. Dawson, D.C. & Frizzell, R.A. pp 125-137. New York: Rockefeller University Press.
6. HIGGINS, C.F. (1995). The ABC of channel regulation. Cell, 82, 693-696.
7. HOLLO, Z., HOMOLYKA, L., HEGEDÜS, T. & SARKADI, B. (1996). Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells. FEBS Letts., 383, 99-104.
8. HYDE, S.C., EMSLEY, P., HARTSHORN, M.J., MIMMACK, M.M., GILEADI, U., PEARCE, S.R., GALLAGHER, M.P., GILL, D.R., HUBBARD, R.E. & HIGGINS, C.F. (1990). Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature, 346, 362-365.
9. JEDLITSCHKY, G., LEIER, I., BUCHHOLZ, U., BARNOUIN, K., KURZ, G. & KEPPLER, D. (1996). Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res., 56, 988-994.
10. KEPPLER, D., LEIER, I. & JEDLITSCHK, G. (1997). Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRPI and MRP2. Biol. Chem., 378, 787-791.
11. LALLEMAND, J.Y., STOVEN, V., ANNEREAU, J.P., BOUCHER, J., BLANQUET, S., BARTHE, J. & LENOIR, G. (1997). Induction by antitumoral drugs of proteins that functionally complement CFTR: a novel therapy for cystic fibrosis? Lancet, 350, 711-712.
12. LEIER, I., JEDLITSCHKY, G., BUCHHOLZ, U., COLE, S.P.C., DEELEY, R.G. & KEPPLER, D. (1994). The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem., 269, 27807-27810
13. LINSDELL, P. & HANRAHAN, J.W. (1996a). Flickery block of single CFTR chloride channels by intracellular anions and osmolytes. Am. J. Physiol., 271, C628-C634.
14. LINSDELL, P. & HANRAHAN, J.W. (1996b). Disulphonic stilbene block of cystic fibrosis transmembrane conductance regulator Cl-channels expressed in a mammalian cell line and its regulation by a critical pore residue. J. Physiol., 496, 687-693.
15. LINSDELL, P. & HANRAHAN, J.W. (1998a). Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel. J. Gen. Physiol., 11, 601-614.
16. LINSDELL, P. & HANRAHAN, J.W. (1998b). Glutathione permeability of CFTR. Am. J. Physiol., 275, C323-C326.
17. LINSDELL, P., TABCHARANI, J.A. & HANRAHAN, J.W. (1997). Multi-ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel. J. Gen. Physiol., 110, 365-377.
18. LOE, D.W., ALMQUIST, K.C., COLE, S.P.C. & DEELEY, R.G. (1996). ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J. Biol. Chem., 271, 9683-9689.
19. MCCARTY. N.A., MCDONOUGH, S., COHEN, B.N., RIORDAN, J.R., DAVIDSON, N. & LESTER, H.A. (1993). Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl-channel by two closely related arylaminobenzoates. J. Gen. Physiol., 102, 1-23.
20. MCDONOUGH, S., DAVIDSON, N., LESTER, H.A. & MCCARTY, N.A. (1994). Novel pore-lining residues in CFTR that govern permeation and open-channel block. Neuron, 13, 623-634.
21. MÜLLER, M. & JANSEN, P.L.M. (1997). Molecular aspects of hepatobiliary transport. Am. J. Physiol., 272, G1285-G1303
22. ORTIZ, D.F., ST. PIERRE, M.V., ABDULMESSIH, A. & ARIAS, I.M. (1997). A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J. Biol. Chem., 272, 15358-15365.
23. OUDE ELFERINK, R.P.J., MEIJER, D.K.F., KUIPERS, F., JANSEN, P.L.M., GROEN, A.K. & GROOTHUIS, G.M.M. (1995). Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim. Biophys. Acta, 1241, 215-268.
24. SAXENA, M. & HENDERSON, G.B. (1996). MOAT4, a novel multispecific organic-anion transporter for glucuronides and mercapturates in mouse L1210 cells and human erythrocytes. Biochem. J., 320, 273-281.
25. SCHULTZ, B.D., DEROOS, A.D.G., VENGLARIK, C.J., SINGH, A.K., FRIZZELL, R.A. & BRIDGES, R.J. (1996). Glibenclamide blockade of CFTR chloride channels. Am. J. PhysioL, 271, L192 -L200.
26. SHEPPARD, D.N. & ROBINSON, K.A. (1997). Mechanism of glibenclamide inhibition of cystic fibrosis transmembrane conductance regulator Cl channels expressed in a murine cell line. J. Physiol., 503, 333-346.
27. SHEPPARD, D.N. & WELSH, M.J. (1992). Effect of ATP-sensitive K-channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. J. Gen. Physiol., 100, 573-591.
28. SINGH, A.K., BRADBURY, N.A., SCHULTZ, B.D., PRICE, E., FRIZZELl, R.A. & BRIDGES, R.J. (1995). Photoaffinity labeling of CFTR by radiolabeled estrogens: evidence for direct binding of estrogens to CFTR. Pediatr. Pulmonol., 12, 197 (abstract).
29. - secretion. Pediatr. Pulmonol. 10, 186 (abstract).
30. TABCHARANI, J.A., CHANG, X.-B., RIORDAN, J.R. & HANRAHAN, J.W. (1991). Phosphorylation-regulated Cl channel in CHO cells by stably expressing the cystic fibrosis gene. Nature, 352, 628-631.
31. - channels. Biophys. J., 70, 2696-2703.
32. WALSH, K.B. & WANG, C. (1998). Arylaminobenzoate block of the cardiac cyclic AMP-dependent chloride channel. Mol. Pharmacol., 53, 539-546.
33. WOODHULL, A.M. (1973). Ionic blockage of sodium channels in nerve. J. Gen. Physiol., 61, 687-708.