Immunohistochemical detection of Bcl-2 protein in small cell carcinomas

Oncology (Switzerland)

Volumn 53, Issue 1, 1996, Pages 6-11

  Yan, Jing Jou ^a   Chen, Fen Fen ^a   Tsai, Yi Chang ^a   Jin, Ying Tai ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Bcl 2 protein; Immunohistochemistry; p53 oncoprotein; Small cell carcinoma

Indexed keywords

PROTEIN BCL 2; PROTEIN P53; TUMOR MARKER;

ARTICLE; BIOPSY; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER METASTASIS; LUNG SMALL CELL CANCER; LYMPH NODE METASTASIS; PRIORITY JOURNAL; SMALL CELL CARCINOMA; STEM CELL;

CARCINOMA, SMALL CELL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS; UTERINE NEOPLASMS;

EID: 0030029161     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000227526     Document Type: Article

References (16)

1. Tsujimoto Y, Finger LR, Yunis J, Nowell PC. Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14:18) chromosome translocation. Science 1984:226: 1097-1099.
2. Cleary ML, Smith ST, Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the 1(14:18) translocation. Cell 1986; 47:19-28.
3. Korsmeyer SJ: Bel-2 initiates a new category of oncogenes: Regulators of cell death. Blood 1992;80:879-886.
4. Pezzella F, Turley H, Kuzu I, Tungekar MF, Dunnill MS, Pierce CB, Harris A, Gatter KC, Mason DY: bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993:329:690-694.
5. Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL: Bel-2 in normal human breast and carcinoma, association with oestrogen receptor-positive. epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 1994:69:135-139.
6. Ikegaki N, Katsumata M, Minna J, Tsujimoto Y: Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res 1994:54:6-8.
7. Miyashita T, Reed JC: bel-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 1992;52:5407-5411.
8. Haidar S, Negrini M, Monne M, Sabbioni S, Croce CM: Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 1994:54:2095-2097.
9. Hirsch FR, Matthews MJ, Aisner S, Campobasso O. Elema JD, Gazdar AF, Mackay B. Nasiell M, Shimosato Y, Steele RH, Yesner R. Zettergren L: Histopathologic classification of small cell lung cancer: Changing concepts and terminology. Cancer 1988;62:973-977.
10. Shi SR, Key ME, Kalra KL: Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for inimunohisto-chemical staining based on microwave oven heating of tissue sections. J Histochcm Cyto-chem 1991;39:741-748.
11. Goodwin G, Shaper JH, Abeloff MD, Mendelsohn G, Baylin SB: Analysis of cell surface proteins delineates a differentiation pathway linking endocrine and nonendocrinc human lung cancers. Proc Nall Acad Sci USA 1983;80: 3807-3811.
12. Yonish-Rouach E, Rensmitzki D, Lotem J, Sachs L, Kimchi A, Oren M: Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin 6. Nature 1991; 352:345-347.
13. Lotem J, Sachs L: Regulation by bel-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 1993;4:41-47.
14. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo Oncogene 1994;9:1799-1805.
15. Marin MC, Hsu B, Meyn RE, Donehower LA, El-Naggar AK, McDonnell TJ: Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lympho-magcnesis. Oncogene 1994,9:3107-3112.
16. Minna JD, Pass H, Galstein E, Ihde D: Cancer of the lung; in Devita VT, Heilman S. Rosenberg SA (eds): Cancer. Principle and Practice of Oncology. Philadelphia. Lippincott. 1989, pp 591-705.