Targeting AIDS-Kaposi's sarcoma

Nature Medicine

Volumn 5, Issue 7, 1999, Pages 738-739

  Mesri, Enrique A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; PE38KDEL; PSEUDOMONAS EXOTOXIN; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTINEOPLASTIC ACTIVITY; KAPOSI SARCOMA; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SHORT SURVEY; TARGET CELL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; HUMANS; IMMUNOTOXINS; INTERLEUKIN-4; MICE; MICE, NUDE; PROTEIN HYBRIDIZATION; PSEUDOMONAS AERUGINOSA; RECOMBINANT FUSION PROTEINS; SARCOMA, KAPOSI; TRANSPLANTATION, HETEROLOGOUS;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS EXOTOXIN;

EID: 0033025409     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/10459     Document Type: Short Survey

References (15)

1. McGarvey, M.E. et al. Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma. Curr Opin. Oncol. 10, 413-421 (1998).
2. Gallo, R.C. The enigmas of Kaposi's sarcoma. Science 282, 1837-1839 (1998).
3. Boshoff, C. & Weiss, R.A. Kaposi's sarcoma-associated herpesvirus. Adv. Cancer Res. 75, 57-86 (1998).
4. Pastan, I., Chaudhary, V. & FitzGerald, D.J. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 61, 331-354 (1992).
5. Thrush, G.R., Lark, L.R., Clinchy, B.C. & Vitetta, E.S. Immunotoxins: an update. Annu. Rev. Immunol. 14, 49-71 (1996).
6. Hussain, S.R., Kreitman, R.J., Pastan, I. & Puri, R.K. Interleukin-4 receptor directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model. Nature Med. 5, 817-822 (1999).
7. Frankel, A.E. & Willingham, M.C. Clinical applications of immunotoxins. Conclusion. Curr. Top. Microbiol. Immunol. 234, 115-120 (1998).
8. Vitetta, E., Ghetie, M. & Ghetie, V. in Monoclonal Antibody-Based Therapy of Cancer (ed. Grossbard, M.L.) 417-431 (Marcel Dekker, New York, 1998).
9. Pastan, I. Targeted therapy of cancer with recombinant immunotoxins. Biochim. Biophys. Acta 1333, C1-6 (1997).
10. Kreitman, R.J., Puri, R.K. & Pastan, I. A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc. Natl. Acad. Sci. USA 91, 6889-6893 (1994).
11. Pai, L.H., Wittes, R., Setser, A., Willingham, M.C. & Pastan, I. Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nature Med. 2, 350-353 (1996).
12. Laske, D.W., Youle, R.J. & Oldfield, E.H. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med. 3, 1362-1368 (1997).
13. Foss, F.M., Saleh, M.N., Krueger, J.G., Nichols, J.C. & Murphy, J.R. Diphtheria toxin fusion proteins. Curr. Top. Microbiol. Immunol. 234, 63-81 (1998).
14. Sausville, E.A. et al. Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study. Blood 85, 3457-3465 (1995).
15. Kreitman, R.J. et al. Phase I trial of recombinant immunotoxin Anti-Tac(Fv)-PE38 (LMB-2 in patients with hematologic malignancies. Blood 92, 413a (1998).