Cytokine and immunoglobulin concentrations in cervical secretions: Reproducibility of the Weck-cel collection instrument and correlates of immune measures

Journal of Immunological Methods

Volumn 225, Issue 1-2, 1999, Pages 131-143

  Hildesheim, Allan ^a   McShane, Lisa M ^b   Schiffman, Mark ^a   Bratti, M Concepcion ^c   Rodriguez, Ana C ^c,d   Herrero, Rolando ^d,e   Morera, Lidia A ^c   Cardenas, Fernando ^c   Saxon, Linda ^f   Bowman, Frederick P ^g   Crowley Nowick, Peggy A ^g  

^a Environ Epidemiol Br DCEG N   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Social Security Administration   (Costa Rica)

^d Ministry of Health   (Costa Rica)

^e INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^f INFORMATION MANAGEMENT SERVICES INC   (United States)

^g Gynecol   (United States)

Author keywords

Cytokines; Genital tract; Immunoglobulin; Mucosal immunology

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 12;

ADULT; AGE; AGED; ANALYTIC METHOD; ARTICLE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; MUCOSAL IMMUNITY; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SAMPLING; SEXUALLY TRANSMITTED DISEASE; SPONGE; UTERINE CERVIX MUCUS;

ADULT; CERVIX MUCUS; CERVIX UTERI; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKIN-12; MIDDLE AGED; TIME FACTORS;

EID: 0033025208     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00037-X     Document Type: Article

References (34)

1. Adashi, E.Y., Rock, J.A., Rosenwaks, Z., 1996. Reproductive Endocrinology, Surgery, and Technology. Lippincott-Raven, Philadelphia.
2. Agresti, A., 1990. Models for matched pairs. In: Anonymous (Ed.), Categorical Data Analysis. Wiley, New York, pp. 347-385.
3. Ashley R.L., Corey L., Dalessio J., Wilson P., Remington M., Barnum G., Trethewey P. Protein-specific cervical antibody responses to primary genital herpes simplex virus type 2 infections. JID. 170:1994;20-26.
4. Ashley R.L., Crisostomo F.M., Doss M., Sekulovich R.E., Burke R.L., Shaughnessy M., Corey L., Polissar N.L., Langenberg A.G. Cervical antibody responses to a herpes simplex virus type 2 glycoprotein subunit vaccine. JID. 178:1998;1-7.
5. Belec L., Meillet D., Levy M., Georges A., Tevi-Benissan C., Pillot J. Dilution assessment of cervicovaginal secretions obtained by vaginal washing for immunological assays. Clin. Diagn. Lab. Immunol. 2:1995;57-61.
6. Boursnell M.E., Entwisle C., Blakeley D., Roberts C., Duncan I.A., Chisholm S.E., Martin G.M., Jennings R., Ni Challanain D., Sobek I., Inglis S.C., McLean C.S. A genetically inactivated HSV-2 vaccine provides protection against primary and recurrent HSV-2 disease. JID. 175:1997;16-25.
7. Bouvet J.P., Belec L., Pires R., Pillot J. Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination. Infect. Immun. 62:1994;3957-3961.
8. Brandtzaeg P. Mucosal immunity in the female genital tract. J. Reprod. Immunol. 36:1997;23-50.
9. Crowley-Nowick P.A., Krasnow J., Kulhavy L., Wolf K., Gooding B., Edwards R.P. The influence of progesterone on cervical mucus immunoglobulin and cytokine concentrations. Clin. Immunol. Immunopathol. 76:1995;S41.
10. Crowley-Nowick P.A., Bell M., Edwards R.P., McCallister D., Gore H., Kanbour-Shakir A., Mestecky J., Partridge E.E. Normal uterin cervix: characterization of isolated lymphocyte phenotypes and immunoglobulin secretion. Am. J. Reprod. Immunol. 34:1995;241-247.
11. Crowley-Nowick P.A., Bell M.C., Brockwell R., Edwards R.P., Chen S., Partridge E.E., Mestecky J. Rectal immunization for induction of specific antibody in the genital tract of women. J. Clin. Immunol. 17:1997;370-379.
12. Dixon, W.J., Massey, F.J., 1983. Introduction to Statistical Analysis. McGraw-Hill, New York.
13. Haneberg B., Kendall D., Amerongen H.M., Apter F.M., Kraehenbuhl J.P., Neutra M.R. Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect. Immun. 62:1994;15-23.
14. Herrero R., Schiffman M.H., Bratti C., Hildesheim A., Balmaceda I., Sherman M.E., Greenberg M., Cardenas F., Gomez V., Helgesen K., Morales J., Hutchinson M., Mango L., Alfaro M., Potischman N.W., Wacholder S., Swanson C., Brinton L.A. Design and methods of a population-based natural history study of cervical neoplasia in a rural province of Costa Rica: the Guanacaste project. Pan. Am. J. Public Health. 1:1997;362-374.
15. Hildesheim A., Schiffman M.H., Tsukui T., Swanson C.A., Lucci J., Scott D.R., Lawler P., Rush B.B., Lorincz A.T., Corrigan A., Burk R.D., Helgesen K., Houghten R.A., Berzofsky J.A., Kramer T.R. Immune activation in cervical neoplasia: cross-sectional association between plasma sIL-2R levels and disease. Cancer Epidemiol. Biomarkers Prev. 6:1997;807-813.
16. Hildesheim, A., Bratti, M.C., Edwards, R.P., Schiffman, M., Rodriguez, A.C., Herrero, R., Alfaro, M., Morera, L.A., Ermatinger, S.V., Miller, B.T., Crowley-Nowick, P.A., 1998. Collection of cervical secretions does not adversely affect Pap smears taken immediately afterward. Clin. Diagn. Lab. Immunol., in press.
17. Hines J.F., Ghim S., Schlegel R., Jenson A.B. Prospects for a vaccine against human papillomavirus. Obstet. Gynecol. 86(5):1995;860-866.
18. Jackson S., Galla J.H., Kirk K.A., Thorn B.T., Julian B.A. Epstein-Barr virus transformation of B lymphocytes from IgA nephropathy patients and first-degree relatives results in increased immunoglobulin synthesis not restricted to IgA. Am. J. Kidney Dis. 17:1991;55-61.
19. Jarrett W.F.H., Smith K.T., O'Neil B.W., Gaukroger J.M., Chandrachud L.M., Grindlay G.J., McGarvie G.M., Campo M.S. Studies on vaccination against papillomaviruses: prophylactic and therapeutic vaccination with recombinant structural proteins. Virology. 184:1997;33-42.
20. Kelsey, J.L., Thompson, W.D., Evans, A.S., 1986. Methods in Observational Epidemiology. Oxford Univ. Press, New York.
21. Kutteh W.H., Prince S.J., Hammond K.R., Kutteh C.C., Mestecky J. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin. Exp. Immunol. 104:1996;538-542.
22. Mestecky J., Kutteh W.H., Jackson S. Mucosal immunity in the female genital tract: relevance to vaccination efforts against the human immunodeficiency virus. AIDS Res. Hum. Retroviruses. 10:1994;S11-S20.
23. Olaitan A., Johnson M.A., Reid W.M., Poulter L.W. Changes to the cytokine microenvironment in the genital tract mucosa of HIV+women. Clin. Exp. Immunol. 112:1998;100-104.
24. Paganelli R., Quinta I., Fagiolo U., Cossarizza A., Ortolani C., Guerra E., Sansoni P., Pucillo L.P., Scala E., Cozzi E. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin. Exp. Immunol. 90:1992;351-354.
25. Quesnel A., Cu-Uvin S., Murphy D., Ashley R.L., Flanigan T., Neutra M.R. Comparative analysis of methods for collection and measurement of immunoglobulins in cervical and vaginal secretions of women. J. Immunol. Methods. 202:1997;153-161.
26. Rosenthal K.L., Gallichan W.S. Challenges for vaccination against sexually-transmitted diseases: induction and long-term maintenance of mucosal immune responses in the female genital tract. Semin. Immunol. 9:1997;303-314.
27. SAS Institute, 1992. I. The mixed procedure. SAS technical report P-229: SAS/STAT software changes and enhancements. Cary, SAS Institute, NC, p. 287.
28. Schiller J.T., Lowy D.R. Papillomavirus-like particles and HPV vaccine development. Cancer Biol. 7:1996;373-382.
29. Scott P. IL-12: initiation cytokine for cell-mediated immunity. Science. 260:1992;496-497.
30. Searle, S.R., Casella, G., McCulloh, C.E., 1992. Variance Components. Wiley, New York.
31. Sherman M.E., Schiffman M.H., Strickler H., Hildesheim A. Prospects for a prophylactic HPV vaccine: rationale and future implications for cervical cancer screening. Diagn. Cytopathol. 18:1998;5-9.
32. Sieling P.A., Wang X., Gately M.K., Oliveros J.L., McHugh T., Barnes P.F., Wolf S.F., Golkar L., Yamamura M., Yogi Y., Uyemura K., Rea T.H., Modlin R.L. IL-12 regulates T helper type 1 cytokine responses in human infectious diseases. J. Immunol. 153:1994;3639-3647.
33. Tsukui T., Hildesheim A., Schiffman M.H., Lucci J., Contois D., Lawler P., Rush B.B., Lorincz A.T., Corrigan A., Carbone D.P., Scott D.R., Houghten R.A., Berzofsky J.A. IL-2 production by peripheral lymphocytes in response to human papillomavirus-derived peptides: correlation with cervical pathology. Cancer Res. 56:1996;3967-3974.
34. Wang Z., Hansson B.G., Forslund O., Dillner L., Sapp M., Schiller J.T., Bjerre B., Dillner J. Cervical mucus antibodies against human papillomavirus type 16, 18, and 33 capsids in relation to presence of viral DNA. J. Clin. Microbiol. 34:1996;3056-3062.