Nitric oxide reduces nontransferrin-bound iron transport in HepG2 cells

Hepatology

Volumn 29, Issue 2, 1999, Pages 464-470

  Barisani, Donatella ^a   Cairo, Gaetano ^b   Ginelli, Enrico ^c   Marozzi, Anna ^c   Conte, Dario ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; IRON REGULATORY FACTOR; MESSENGER RNA; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; LIVER CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; REGULATORY MECHANISM;

APOPTOSIS; BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; FERRIC COMPOUNDS; FERRITINS; FERROUS COMPOUNDS; HUMANS; IRON; KINETICS; LIVER NEOPLASMS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROPRUSSIDE; PENICILLAMINE; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; TRANSFERRIN; TUMOR CELLS, CULTURED;

EID: 0033024496     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290205     Document Type: Article

References (26)

1. Billiar TR, Curran RD, Stuehr DJ, West MA, Bentz EG, Simmons RL. An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J Exp Med 1989;169:1467-1472.
2. Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, et al. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Nat Acad Sci U S A 1993;90:522-526.
3. Gross SS. Nitric oxide: pathophysiological mechanisms. Annu Rev Physiol 1995;57:737-769.
4. Roczniak A, Burns KD. Nitric oxide stimulates guanylate cyclase and regulates sodium transport in rabbit proximal tubule. Am J Physiol 1996;270:F106-115.
5. Trauner M, Nathanson M, Mennone A, Rydberg SA, Boyer JL. Nitric oxide donors stimulate bile flow and glutathione disulfide excretion independent of cyclic guanosine 3′5′-cyclic monophosphate in the isolated perfused liver. HEPATOLOGY 1997:25:263-269.
6. Drapier JC, Bouton C. Modulation by nitric oxide of metalloprotein regulatory activities. BioEssays 1996;18:549-556.
7. Hentze MW, Kuhn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Nat Acad Sci U S A 1996;93:8175-8182.
8. Domachowske JB. The role of nitric oxide in the regulation of cellular iron metabolism. Biochem Mol Med 1997;60:1-7.
9. Leibold EA, Guo B. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding proteins. Annu Rev Nutr 1992;12:345-368.
10. Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 1993;72:19-28.
11. Richardson DR, Neumannova V, Nagy E, Ponka P. The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells. Blood 1995;86:3211-3219.
12. Oria R, Sanchez L, Houston T, Henze MW, Liaw FY, Brock JH. Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells. Blood 1995;86:2962-2966.
13. Cairo G, Pietrangelo A. Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation. Eur J Biochem 1995;232:358-353.
14. Phillips JD, Kinikini DV, Yu Y, Guo B, Leibold EA. Differential regulation of IRP1 and IRP2 by nitric oxide rat hepatoma cells. Blood 1996;87:29832992.
15. Sanchez L, Ismail M, Liew FY, Brock JH. Iron transport across Caco-2 cell monolayers. Effect of transferrin, lactoferrin and nitric oxide. Biochem Biophys Acta 1996;1289:291-297.
16. Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 1992;258:1898-1902.
17. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, et al. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biological active compounds. Proc Nat Acad Sci U S A 1992;89:444-448.
18. Reif DW, Simmons RD. Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys 1991;283:537-541.
19. Sergent O, Griffon B, Morel I, Chevanne M, Dubos MP, Cillard P, Cillard J. Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocytes. HEPATOLOGY 1997;25:122-127.
20. 2+ transport. J Biol Chem 1992;267:11490-11494.
21. Sturrock A, Alexander J, Lamb J, Craven CM, Kaplan J. Characterization of a transferrin-independent uptake system for iron in HeLa cells. J Biol Chem 1990;265:3139-3145.
22. Kaplan J, Jordan I, Sturrock A. Regulation of the transferrin-independent iron transport system in cultured cells. J Biol Chem 1991;266:2997-3004.
23. Alvarez-Hernandez X, Nichols GM, Glass J. Caco-2 cell line: a system for studying intestinal iron transport across epithelial cell monolayers. Biochim Biophys Acta 1991;1070:205-208.
24. Inman R, Wessling-Resnick M. Characterization of transferrin-independent iron transport in K562 cells: unique properties provide evidence for multiple pathways of iron uptake. J Biol Chem 1993;268:8521-8528.
25. Brissot P, Wright TL, Ma WL, Weisiger RA. Efficient clearance of non-transferrin-bound iron by rat liver. J Clin Invest 1985;76:1463-1470.
26. Wright TL, Brissot P, Ma WL, Weisiger RA. Characterization of non-transferrin-bound iron clearance by rat liver. J Biol Chem 1986;261:10909-10914.