TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

European Journal of Immunology

Volumn 29, Issue 3, 1999, Pages 774-780

  Kassiotis, George ^a   Pasparakis, Manolis ^a,b   Kollias, George ^a   Probert, Lesley ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Experimental autoimmune encephalomyelitis; Myelin basic protein; SJL; TNF knockout mouse

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELIN BASIC PROTEIN; TUMOR NECROSIS FACTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; GENE LOCUS; HAPLOTYPE; IMMUNOGENETICS; INFLAMMATION; MORBIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY;

EID: 0033024388     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199903)29:03<774::aid-immu774>3.0.co;2-t     Document Type: Article

References (26)

1. Powell, M. B., Mitchell, D., Lederman, J., Buckmeier, J., Zamvil, S. S., Graham, M., Ruddle, N. H. and Steinman, L., Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 1990. 2: 539-544.
2. Chung, I. Y., Norris, J. G. and Benveniste, E. N., Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains. J. Exp. Med. 1991. 173: 801-811.
3. Baron, J. L., Madri, J. A., Ruddle, N. H., Hashim, G. and Janeway, C. A. J., Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 1993. 177: 57-68.
4. Philip, R. and Epstein, L. B., Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature 1986. 323: 86-89.
5. Selmaj, K. W. and Raine, C. S., Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 1988. 23: 339-346.
6. Ruddle, N. H., Bergman, C. M., McGrath, K. M., Lingenheld, E. G., Grunnet, M. L., Padula, S. J. and Clark, R. B., An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 1990. 172: 1193-1200.
7. Baker, D., Butler, D., Scallon, B. J., O'Neill, J. K., Turk, J. L. and Feldmann, M., Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins. Eur. J. Immunol. 1994. 24: 2040-2048.
8. Thomas, K. R. and Capecchi, M. R., Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987. 51: 503-512.
9. Korner, H., Riminton, D. S., Strickland, D. H., Lemckert, F. A., Pollard, J. D. and Sedgwick, J. D., Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J. Exp. Med. 1997. 186: 1585-1590.
10. Liu, J., Marino, M. W., Wong, G., Grail, D., Dunn, A., Bettadapura, J., Slavin, A. J., Old, L. and Bernard, C. C., TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med. 1998. 4: 78-83.
11. Sean, R. D., Korner, H., Strickland, D. H., Lemckert, F. A., Pollard, J. D. and Sedgwick, J. D., Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J. Exp. Med. 1998. 187: 1517-1528.
12. Suen, W. E., Bergman, C. M., Hjelmstrom, P. and Ruddle, N. H., A critical role for lymphotoxin in experimental allergic encephalomyelitis. J. Exp. Med. 1997. 186: 1233-1240.
13. Mendel, I., Kerlero de Rosbo, N. and Ben-Nun, A., A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 1995. 25: 1951-1959.
14. Frei, K., Eugster, H. P., Bopst, M., Constantinescu, C. S., Lavi, E. and Fontana, A., Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. J. Exp. Med. 1997. 185: 2177-2182.
15. Pasparakis, M., Alexopoulou, L., Episkopou, V. and Kollias, G., Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 1996. 184: 1397-1411.
16. Fritz, R. B., Skeen, M. J., Chou, C. H., Garcia, M. and Egorov, I. K., Major histocompatibility complex-linked control of the murine immune response to myelin basic protein. J. Immunol. 1985. 134: 2328-2332.
17. Zamvil, S. S., Mitchell, D. J., Moore, A. C., Schwarz, A. J., Stiefel, W., Nelson, P. A., Rothbard, J. B. and Steinman, L., T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein. J. Immunol. 1987. 139: 1075-1079.
18. Shaw, M. K., Kim, C., Ho, K. L., Lisak, R. P. and Tse, H. Y., A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains. J. Neuroimmunol. 1992. 39: 139-149.
19. Fritz, R. B. and Zhao, M. L., Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice. J. Neurosci. Res. 1996. 45: 471-474.
20. Shaw, M. K., Kim, C., Hao, H. W., Chen, F. and Tse, H. Y., Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor V beta gene segment usage. J. Neurosci. Res. 1996. 45: 690-699.
21. Fritz, R. B. and Kalvakolanu, I., Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J. Neuroimmunol. 1995. 57: 93-99.
22. Yoshizawa, I., Bronson, R., Dorf, M. E. and Abromson-Leeman, S., T-cell responses to myelin basic protein in normal and MBP-deficient mice. J. Neuroimmunol. 1998. 84: 131-138.
23. Harrington, C. J., Paez, A., Hunkapiller, T., Mannikko, V., Brabb, T., Ahearn, M., Beeson, C. and Goverman, J., Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 1998. 8: 571-580.
24. Targoni, O. S. and Lehmann, P. V., Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 1998. 187: 2055-2063.
25. Cope, A. P., Liblau, R. S., Yang, X. D., Congia, M., Laudanna, C., Schreiber, R. D., Probert, L., Kollias, G. and McDevitt, H. O., Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. J. Exp. Med. 1997. 185: 1573-1584.
26. Yang, X. D., Tisch, R., Singer, S. M., Cao, Z. A., Liblau, R. S., Schreiber, R. D. and McDevitt, H. O., Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J. Exp. Med. 1994. 180: 995-1004.