CCAAT/enhancer binding protein α (C/EBPα is an important mediator of mouse C/EBPβ protein isoform production

Hepatology

Volumn 29, Issue 2, 1999, Pages 597-601

  Burgess Beusse, Bonnie L ^a   Timchenko, Nikolai A ^a   Darlington, Gretchen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; GENOTYPE; MOLECULAR WEIGHT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

ANIMALS; ANIMALS, NEWBORN; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FIBROSARCOMA; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; LIVER; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; TUMOR CELLS, CULTURED;

EID: 0033024180     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290245     Document Type: Article

References (22)

1. Vinson CR, Sigler PB, McKnight SL. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 1989;246:911-916.
2. Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, Landschulz WH, McKnight SL. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989;3:1146-1156.
3. McKnight SL, Lane MD, Gluecksohn-Waelsch S. Is CCAAT/enhancer-binding protein a central regulator of energy metabolism? Genes Dev 1989;3:2021-2024.
4. Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, et al. Impaired energy homeostasis in C/EBP alpha knock-out mice. Science 1995;269:1108-1112.
5. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 1991;5:1538-1552.
6. Zhang D-E, Zhang P, Wang N-D, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A 1997;94:569-574.
7. Timchenko NA, Wilde M, Nakanishi M, Smith JR, Darlington GJ. CCAAT/enhancer binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-l/SDI-1) protein. Genes Dev 1996;10:804-815.
8. Timchenko NA, Harris TE, Wilde M, Bilyeu TA, Burgess-Beusse BL, Finegold MJ, Darlington GJ. CCAAT/Enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice. Mol Cell Biol 1997;17:7353-7361.
9. Alam T, An MR, Papaconstantinou J. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J Biol Chem 1992;267:5021-5024.
10. Burgess-Beusse BL, Darlington GJ. C/EBP alpha is critical for the neonatal acute-phase response to inflammation. Mol Cell Biol 1998;18:7269-7277.
11. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibier U. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev 1990;4:1541-1551.
12. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 1995;80:353-361.
13. Screpanti I, Musiani P, Bellavia D, Cappelletti M, Aiello FB, Maroder M, Frati L, et al. Inactivation of the IL-6 gene prevents development of multicentric Castleman's diesase in C/EBP beta-deficient mice. J Exp Med 1996;184:1561-1566.
14. Raught B, Liao WS, Rosen JM. Developmentally and hormonally regulated CCAAT/enhancer binding protein isoforms influence β-casein gene expression. Mol Endocrinol 1995;9:1223-1232.
15. Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM. C/EBP beta, but not C/EBP alpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev 1998;12:1917-1998.
16. Robinson GW, Johnson PF, Hennighausen L, Sterneck E. The C/EBP beta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland. Genes Dev 1998;12:1907-1916.
17. Sterneck E, Tessarollo L, Johnson PE An essential role for C/EBP beta in female reproduction. Genes Dev 1997;11:2153-2162.
18. Pall M, Hellberg P, Brannstrom M, Mikuni M, Peterson CM, Sundfeldt K, Norden B, et al. The transcription factor C/EBP-beta and its role in ovarian function: evidence for direct involvement in the ovulatory process. EMBO J 1997;16:5273-5279.
19. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 1990;9:1897-1906.
20. Cappelletti M, Alonzi T, Faltori E, Liberi C, Poli V. C/EBP beta is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not interleukin-6, regulation. Cell Death Diff 1996;3:29-35.
21. Landschulz WH, Johnson PF, Adashi EY, Graves BJ, McKnight SL. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev 1988;2:786-800.
22. Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 1991;5:1553-1567.