Molecular biology for the critical care physician Part II: Where are we now?

Critical Care Medicine

Volumn 27, Issue 5, 1999, Pages 997-1003

  Santis, George ^a   Evans, Timothy W ^b  

^a GUY S HOSPITAL   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Gene therapy; Genetics; Molecular biology; Molecular diagnosis

Indexed keywords

RECOMBINANT DNA;

CLINICAL MEDICINE; GENE THERAPY; GENE TRANSFER; GENETICS; HUMAN; INTENSIVE CARE; MOLECULAR BIOLOGY; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; REVIEW;

CRITICAL CARE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETICS, MEDICAL; HUMANS; MOLECULAR BIOLOGY; POLYMORPHISM, GENETIC;

EID: 0033023438     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199905000-00043     Document Type: Review

References (53)

1. 1. Bolstein D, White DL, Skolnick M, et al: Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 1980; 33:314-331
2. 2. Collins FS, Guyer MS, Chakravarti A: Variations on a theme. Cataloging human DNA sequence variations. Science 1997; 278:1580-1581
3. 3. Dib C: A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 1996; 380: 152-154
4. 4. Saunders AM, Hulette C, Welsh-Bohmer KA, et al: Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet 1996; 348:90-93
5. 5. Mayeux R, Saunders AM, Shea S, et al: Utility of Apolipoprotein E genotype in the diagnosis of Alzheimer's disease. N Engl J Med 1998; 338:506-511
6. 6. Breitner JC: ApoE genotyping and Alzheimer's disease. Lancet 1996; 347:1184-1185
7. 7. Sherrington R, Rogaev EL, Liang Y, et al: Cloning of a gene bearing mutations in early-onset familial Alzheimer's disease. Nature 1995; 375:754-760
8. 8. Alzheimer's Disease Collaborative Group: The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early-onset AD families. Nat Genet 1995; 11:219-222
9. 9. Levy-Lahad E, Wasco W, Poorkaj P, et al: Candidate gene for chromosome 1 familial Alzheimer's disease locus. Science 1995; 269:973-977
10. 10. Goat A, Chartier-Harlin MC, Mullan M, et al: Segregation of missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349:704-706
11. 11. Scheuner D, Eckman C, Jensen M, et al: Secreted amyloid beta protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenelin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine 1996; 2: 864-870
12. 12. Lifton RP: Molecular genetics of human blood pressure variation. Science 1996; 272:676-680
13. 13. Tiret L, Bonnardeaux A, Poirier O, et al: Synergistic effects of angiotensin-converting enzyme and angiotensin II receptor gene polymorphisms on risk of myocardial infarction. 1994; Lancet 334:910-913
14. 14. Nakauchi Y, Sueshiro T, Yamamoto M, et al: Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease. Atherosclerosis 1996; 125:161-169
15. 15. Kaski JC: Are polymorphisms in the ACE gene a potent genetic risk for restenosis? Br Heart J 1994; 72:101
16. 16. Dudley C, Keavney B, Casadei B, et al: Prediction of patient responses to anti-hypertensive drugs using genetic polymorphisms: Investigation of renin-angiotensin system genes. J Hypertens 1996; 14:259-262
17. 17. Benetos A, Gautier S, Ricard S, et al: Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. Circulation 1996; 94:698-703
18. 18. Iacoviello L, Di Castelnuovo A, Kniff DP, et al: Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction. N Engl J Med 1998; 338:79-85
19. 19. Kuivenhoven JA, Jukema JW, Zwinderman AH, et al: The role of the common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. N Engl J Med 1998; 338:86-93
20. 20. Stuber F, Petersen M, Bokelmann F, et al: A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 1996; 24:381-386
21. 21. Cooper DN, Smith BA, Cooke HJ, et al: An estimate of unique sequence heterozygosity in human genome. Hum Genet 1985; 69:201-205
22. 22. Kruglak L: The use of a genetic map of biallelic markers in linkage studies. Nat Genet 1997; 17:21-24
23. 23. Leven M, Goossens H: Relevance of nucleic acid amplification techniques for the diagnosis of respiratory tract infections in the clinical laboratory. Clin Microbiol Rev 1997; 10:242-256
24. 24. Abe C, Hirano K, Wada M, et al: Detection of M. tuberculosis in clinical specimens by polymerase chain reaction and GenProbe amplified M. tuberculosis direct test. J Clin Microbiol 1993; 31: 247-263
25. 25. Bennesden J, Thomsen VO, Pfyffer GE, et al: Utility of PCR in diagnosing pulmonary tuberculosis. J Clin Microbiol 1996; 34:1407-1411
26. 26. Vago L, Barberis M, Gori A, et al: Nested polymerase chain reaction for Mycobacterium tuberculosis IS6110 sequence on formalin-fixed paraffin-embedded tissues with granulomatous diseases for the rapid diagnosis of tuberculosis. Am J Clin Pathol 1998; 109:411-415
27. 27. Shimm JJ, Cheong HJ, Kang EY, et al: Nested polymerase chain reaction for the detection of Mycobacterium tuberculosis in solitary pulmonary nodules. Chest 1998; 113:20-24
28. 28. Brugiere O, Vokurka M, Lecossier D, et al: Diagnosis of smear-negative pulmonary tuberculosis using sequence capture polymerase chain reaction. Am J Respir Crit Care Med 1997; 155: 1478-1481
29. 29. Verma A, Dasgupta N, Aggrawal AN, et al: Utility of a Mycobacterium tuberculosis GC-rich repetitive sequence in the diagnosis of tuberculous pleural effusion by PCR. Indian J Biochem Biophys 1995; 32:429-436
30. 30. Margall N, Baselga E, Coll P, et al: Detection of Mycobacterium tuberculosis complex DNA by the polymerase chain reaction for rapid diagnosis of cutaneous tuberculosis. Br J Dermatol 1996; 135:231-236
31. 31. Otal I, Martin C, Vincent-Levy-Frebault V, et al: Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis. J Clin Microbiol 1991; 29: 1252-1254
32. 32. Neimark H, Ali Baig M, Carleton S: Direct identification and typing of Mycobacterium tuberculosis by PCR. J Clin Microbiol 1996; 34:2454-2459
33. 33. Prod'hom G, Guilhot C, Gutierrez MC, et al: Rapid discrimination of Mycobacterium tuberculosis complex strains by ligation-mediated PCR fingerprint analysis. J Clin Microbiol 1997; 35:3331-3334
34. 34. Cockerill FR, Williams DE, Eisenach KD, et al: Prospective evaluation of the utility of molecular techniques for the diagnosing nosocomial transmission of multidrug-resistant tuberculosis. Mayo Clin Proc 1996; 71:221-229
35. 35. Telenti A, Imboden P, Marchesi F, et al: Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. Lancet 1993; 341:647-650
36. 36. Goyal M, Shaw R, Benerjee DK, et al: Rapid detection of multidrug-resistant tuberculosis. Eur Respir J 1997; 10:1120-1124
37. 37. Einsele H, Hebart H, Roller G, et al: Detection and identification of fungal pathogens in blood by using molecular probes. J Clin Microbiol 1997; 35: 1353-1360
38. 38. Shin JH, Nolte FS, Morrison CJ: Rapid identification of Candida species in blood cultures by a clinically useful PCR method. J Clin Microbiol 1997; 35: 1454-1459
39. 39. Wakefield AE, Guiver L, Miller RF, et al: UNA amplification on induced sputum samples for diagnosis of Pneumocystis carinii pneumonia. Lancet 1991; 337:1378-1379
40. 40. Miller RF, Wakefield RF: Pneumocystis carinii: Molecular taxonomy and epidemiology. J Med Microbiol 1996; 45: 233-235
41. 41. Nabel EG, Pompili VJ, Plautz GE, et al: Gene transfer and vascular disease. Cardiovascular Res 1994; 28:445-445
42. 42. Friedman T: Overcoming the obstacles to gene therapy. Sci Am 1997; 276: 80-85
43. 43. Feigner PL: Non viral strategies for gene therapy. Sci Am 1997; 276:86-90
44. 44. Muzyczka N: Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol 1992; 158:97-129
45. 45. Berkner KL: Development of Adenovirus vectors for the expression of heterologous genes. Biotechniques 1988; 6:617-629
46. 46. Kolls J, Peppel K, Suva M, et al: Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc Natl Acad Sci USA 1994; 91:215-219
47. 47. Conary JT, Parker RE, Christman BW, et al: Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. J Clin Invest 1994; 93:1834-1840
48. 48. Euzurum SC, Lemarchand P, Rosenfeld MA, et al: Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA. Nucleic Acids Res 1993; 21:1607-1612
49. 49. Ludwig S, Rapp UR: Cascading towards vascular gene therapy. Nature Medicine 1995; 1:513-515
50. 50. Powell JS: Inhibitors of angiotensin converting enzyme prevent neointimal proliferation after vascular injury. Science 1989; 245:186-188
51. 51. Ottlinger ME, Pukac LA, Karnovsky MJ: Heparin inhibits mitogen-activated protein kinase activated protein kinase activation in intact rat vascular smooth muscle. J Biol Chem 1993; 268: 19173-19176
52. 52. Indolfi C: Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Medicine 1995; 1:541-545
53. 53. Janssens SP, Bloch KD, Nong Z, et al: Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest 1996; 98:317-324