Procainamide inhibition of human hepatic degradation of cocaine and cocaethylene in vitro

Journal of Analytical Toxicology

Volumn 23, Issue 3, 1999, Pages 173-176

  Bailey, David N ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; COCAINE; HOMOCOCAINE; PROCAINAMIDE;

ARTICLE; CARDIOTOXICITY; COCAINE DEPENDENCE; DRUG EFFECT; DRUG MECHANISM; ESTERIFICATION; HUMAN; HUMAN TISSUE; LIVER METABOLISM;

EID: 0033022874     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/23.3.173     Document Type: Article

References (12)

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10. M.R. Brzezinski, T.L. Abraham, C.L. Stone, R.A. Dean, and W.F. Bosron. Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem. Pharmacol. 48: 1747-1755 (1994).
11. R.A. Dean, C.D. Christian, R.H.B. Sample, and W.F. Bosron. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J. 5: 2735-2739 (1991).
12. C.P. O'Brien. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, J.G. Hardman and L.E. Limbird, Eds. McCraw-Hill, New York, NY, 1996, pp 569-571.