Squamous cell carcinoma of the vulva: Study of ploidy, HPV, p53, and pRb

International Journal of Gynecological Pathology

Volumn 18, Issue 3, 1999, Pages 191-197

  Lerma, Enrique ^a   Matias Guiu, Xavier ^a   Lee, Soon Ja ^a   Prat, Jaime ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

p53; Ploidy, HPV; pRb; Squamous cell carcinoma; Vulva; Vulvar neoplasia

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LICHEN SCLEROSUS ET ATROPHICUS; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; VULVA CARCINOMA;

EID: 0033022833     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-199907000-00001     Document Type: Article

References (49)

1. Creasman WT, Phillips JL, Menck HR. The National Cancer data base report on early stage invasive vulvar carcinoma. Cancer 1997;80:505-13.
2. Homesley HD, Bundy BN, Sedlis A. Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study). Gynecol Oncol 1993;49:279-83.
3. Homesley HD. Management of vulvar cancer. Cancer 1995;76: 2159-70.
4. Wilkinson EJ, Kneale B, Lynch PJ. Report of the ISSVD Terminology Committee. Proceedings of the eight World Congress. Stockholm, Sweden. J Reprod Med 1986;31:973-4.
5. Ansink A. Vulvar squamous cell carcinoma. Semin Dermatol 1996;15:51-9.
6. Crum CP. Carcinoma of the vulva: Epidemiology and pathogenesis. Obstet Gynecol 1992;79:448-54.
7. Trimble CL, Hildesheim A, Brinton LA, Shah KV, Kurman RJ. Heterogeneous etiology of squamous carcinoma of the vulva. Obstet Gynecol 1996;87:59-64.
8. Toki T, Kurman RJ, Park JS, Kessis T, Daniel RW, Shah K. Probable nonpapillomavirus etiology of squamous cell carcinoma of the vulva in older women: a clinicopathologic study using in situ hybridization and polymerase chain reaction. Int J Gynecol Pathol 1991;10:107-25.
9. Kurman RJ, Toki T, Schiffman MH. Basaloid and warty carcinomas of the vulva: distinctive type of squamous cell carcinoma frequently associated with human papillomaviruses. Am J Surg Pathol 1993;17:133-45.
10. Jones RW, Baranyai J, Stables S. Trends in squamous cell carcinoma of the vulva: the influence of vulvar intraepithelial neoplasia. Obstet Gynecol 1997;90:448-52.
11. Crum CP. Vulvar intraepithelial neoplasia: Histology and associated viral changes. In: Wilkinson E, ed. Pathology of the vulva and vagina. New York, NY: Churchill Livingstone, 1987:79-102.
12. Prat J. Pathology of vulvar intraepithelial lesions and early invasive carcinoma. Hum Pathol 1991;22:877-83.
13. Wilkinson EJ. Benign diseases of vulva. In: Kurman RJ, ed. Blaustein's pathology of the female genital tract, 4th ed. New York, NY: Springer Verlag, 1994:31-86.
14. Hirama T, Koeffler HP. Role of the cyclin-dependent Kinase inhibitors in the development of cancer. Blood 1995;86:841-54.
15. Levine AJ. The tumor suppressor genes. Ann Rev Biochem 1993; 62:623-51.
16. Sherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
17. Kohlberger P, Kainz C, Breitenecker G, et al. Prognostic value of immunohistochemically detected p53 expression in vulvar carcinoma. Cancer 1995;76:1787-9.
18. Walts AE, Koeffler HP, Said JW. Localization of p53 protein and human papillomavirus in anogenital squamous lesions: immunohistochemical and in situ hybridization studies in benign dysplastic, and malignant epithelia. Hum Pathol 1993;24:1238-42.
19. Kim YT, Thomas NF, Kessis TD, Wilkinson, Hedrick L, Cho KR. p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias do not serve as direct precursors of human papillomavirus-negative vulvar carcinomas. Hum Pathol 1996;27:389-95.
20. Lee YY, Wilczynski SP, Chumakov A, Chih D, Koeffler HP. Carcinoma of the vulva: HPV and p53 mutations. Oncogene 1994; 9:1655-9.
21. Sliutz G, Schmidt W, Tempfer C, Speiser P, Gitsch G, Eder S. Detection of p53 point mutations in primary human vulvar cancer by PCR and temperature gradient gel electrophoresis. Gynecol Oncol 1997;64:93-8.
22. Kagie MJ, Kenter GG, Tollenaar RA, Hermans J, Trimbos JB, Fleuren GJ. p53 protein overexpression: a frequent observation in squamous cell carcinoma of the vulva, and in various synchronous epithelia, has no value as a prognostic parameter. Int J Gynecol Pathol 1997;16:124-30.
23. Anglard P, Tory K, Brauch H, et al. Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. Cancer Res 1991;51:1071 -7.
24. Bookstein R, Rio P, Madreperla SA, et al. Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Proc Natl Acad Sci USA 1990;87:7762-6.
25. Logothetis CJ, Xu HJ, Ro JY, et al. Altered retinoblastoma protein expression and known prognostic variables in locally advancer bladder cancer. J Natl Cancer Inst 1992;84:1256-61.
26. Strohmeyer T, Reissman P, Cordon-Cardo C, et al. Correlation between retinoblastoma gene expression and differentiation in human testicular tumors. Proc Natl Acad Sci USA 1991;88:6662-6.
27. Xu HJ, Hu SX, Cagle PT, Moore GE, Benedict WF. Absence of retinoblastoma protein expression in primary non-small lung carcinoma. Cancer Res 1991;51:2735-9.
28. Hacker NF, Berek JS, Lagasse LD, Leuchter RS, Moore JG. Management of regional lymph-nodes and their prognostic influence in vulvar cancer. Obstet Gynecol 1983;61:408-12.
29. Prodratz KC, Symmonds RE, Taylor WF, Williams TJ. Carcinoma of the vulva: analysis of treatment and survival. Obstet Gynecol 1983;61:63-74.
30. Binder SW, Huang I, Fu YS, Hacker NF, Berek JS. Risk factors for the development of lymph-node metastasis in vulvar squamous cell carcinoma. Gynecol Oncol 1990;37:9-16.
31. Husseibzadeh N, Wesseler T, Schneider D, Schelhas H, Nahhas W. Prognostic factors and the significance of cytologic grading in invasive squamous cell carcinoma of vulva: a clinicopathologic study. Gynecol Oncol 1990;36:192-9.
32. Hacker NF. Vulvar cancer. In: Berek JS, Hacker NF, eds. Practical gynecologic oncology. Baltimore, MD: Williams and Wilkins, 1989.
33. Drew PA, al-Abbadi MA, Orlando CA, Hendricks JB, Kubills PS, Wilkinson EJ. Prognostic factors in carcinoma of the vulva: a clinicopathologic and DNA flow cytometric study. Int J Gynecol Pathol 1996;15:235-41.
34. Smyczeck-Garya B, Volz B, Geppert M, Dietl J. A multivariate analysis of clinical and morphological prognostic factors in squamous cell carcinoma of vulva. Gynecol Obstet Invest 1997;43: 261-7.
35. Lininger RA, Tavassoli FA. The pathology of vulvar neoplasia. Curr Opin Obstet Gynecol 1996;8:63-8.
36. Isawara A, Nieminen P, Lentinen M, Paavonen J. Human papilloma virus in squamous cell carcinoma of vulva by polymerase chain reaction. Obstet Gynecol 1997;89:81-4.
37. Hording U, Kringsholm B, Andreasson B, Visfeldt J, Daugaard S, Bock JE. Human papillomavirus in vulvar squamous cell carcinoma and in normal vulvar tissue: a search for possible impact of HPV on vulvar cancer prognosis. Int J Cancer 1993;55:394-6.
38. Buscema J, Naghashfar Z, Sawada E, et al. The predominance of human papillomavirus type 16 in vulvar neoplasia. Obstet Gynecol 1988;71:601-6.
39. Haefner HK, Tate JE, McLachlin CM, Crum CP. Vulvar intraepithelial neoplasia: age, morphological phenotype, papillomavirus DNA, and coexisting invasive carcinoma. Hum Pathol 1995;26: 147-54.
40. Jones RW, Rowan DM. Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma. Obstet Gynecol 1994; 84:741-5.
41. Kagie MJ, Kenter GG, Tollenaar RA, Hermans J, Trimbos JB, Fleuren GJ. p53 protein overexpression is common and independent of human papillomavirus infection in squamous cell carcinoma of the vulva. Cancer 1997;80:1228-33.
42. Kagie MJ, Kenter GG, Hermans J, Trimbos JB, Fleuren GJ. The relevance of various vulvar epithelial changes in the early detection of squamous cell carcinoma of the vulva. Int J Gynecol Cancer 1997;7:50-7.
43. Carlson JA, Ambras R, Malfetano J, et al. Vulvar lichen sclerosus and squamous cell carcinoma: a cohort, case control, and investigational study with historical perspective; implications for chronic inflammation and sclerosis in the development of neoplasia. Hum Pathol 1998;29:932-48.
44. Hart WR, Norris J, Helwig EB. Relation of lichen sclerosus et atrophicus of the vulva to development of carcinoma. Obstet Gynecol 1975;45:369-77.
45. Rodke G, Friedrich EG, Wilkinson EJ. Malignant potential of mixed vulvar dystrophy (lichen sclerosis associated with squamous cell hyperplasia). J Reprod Med 1988;33:545-50.
46. Gomez-Rueda N, Garcia A, Vighi S, Belardi MG, Cardinal L, di Paola G. Epithelial alterations adjacent to invasive squamous carcinoma of the vulva. J Reprod Med 1994;39:526-30.
47. Newton JA, Camplejohn RS, McGibbon DH. A flow cytometric study of the significance of DNA aneuploidy in cutaneous lesion. Br J Dermatol 1987;117:169-74.
48. Tate JE, Mutter GL, Boynton KA, Crum CP. Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias. Am J Pathol 1997;150:315-22.
49. Leibowitch M, Neill S, Pelisse M, Moyal-Baracco M. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol 1990;97:1135-9.