The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non-obese and obese children

Clinical Endocrinology

Volumn 50, Issue 6, 1999, Pages 775-781

  Bona, G ^a   Petri, A ^a   Rapa, A ^a   Conti, A ^b   Sartorio, A ^b  

^a Ospedale Di Novara   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; GENDER; GROWTH HORMONE RELEASE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; PUBERTY; URINARY EXCRETION; URINE LEVEL;

ADOLESCENT; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GROWTH HORMONE; HUMANS; MALE; OBESITY; PUBERTY; REFERENCE VALUES; SEX;

EID: 0033021007     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00728.x     Document Type: Article

References (34)

1. Albini, C.H., Quattrin, T., Vandlen, R.L. & MacGillivray, M.H. (1988) Quantitation of urinary growth hormone in children with normal and abnormal growth. Pediatric Research, 23, 89-92.
2. Baumann, G. (1990) Growth hormone binding proteins and various forms of growth hormone: implications for measurements. Acta Paediatrica Scandinavica, 366 (Suppl.), 149-154.
3. Bell, J.P., Donald, R.A. & Espiner, E.A. (1970) Pituitary responses to insulin-induced hypoglycemia in obese subjects before and after fasting. Journal of Clinical Endocrinology and Metabolism, 31, 546-551.
4. Bercu, B.B., Shulman, D.I, & Root, A.W. (1988) Obesity decreases endogenous growth hormone secretion in children with normal growth velocities. Pediatric Research, 23, 272.
5. Butt, D.A. & Sochett, E.B. (1997) Urinary growth hormone: a screening test for growth hormone sufficiency. Clinical Endocrinology, 47, 447-454.
6. Conti, A., Ferrero, S., Giambona, S. & Sartorio, A, (1998) Urinary free deoxypyridinoline levels during childhood. Journal of Endocrinological Investigation, 21, 318-322.
7. Edge, J.A., Hourd, P., Edwards, R, & Dunger, D.B. (1989) Urinary growth hormone during puberty in normal and diabetic children. Clinical Endocrinology, 30, 413-420.
8. Evans, A.J. & Wood, P.J. (1989) Development of an assay for human growth hormone in urine using commercially available reagents. Annals of Clinical Biochemistry, 26, 353-357.
9. Georges, P., Liefooghe, J., Di Nicola, L, & Chaussain, J.L. (1993) H-GH assay in urine: preliminary results of a French multi-centre evaluation. Pediatric Research, 33 (.Suppl.), S44.
10. Georges, P., Liefooghe, J., Ponchaux, D., Forzy, G., Di Nicola, L. & Chaussain, J.L. (1997) Urinary growth hormone excretion: results of a multicenter study in France. Hormone Research, 47, 30-37.
11. Girard, J., Celniker, A., Price, A., Tanaka, T., Walker, J., Weiling, K. & Albertsson-Wikland, K. (1990) Urinary measurement of growth hormone secretion. Acta Paediatrica Scandinavica, 366 (Suppl.), 149-154.
12. Girard, J., Erb, T., Pampalone, A., Eberle, A.N. & Baumann, J.B. (1987) Growth hormone in urine: development of an ultrasensitive assay to plasma and urine. Hormone Research, 28, 71-80.
13. Hammer, L.D., Kraemer, H.C., Wilson, D., Ritter, P.L. & Dombusch, S.M. (1991) Standardized percentile curves of body-mass index for children and adolescents. American Journal of Diseases of Children, 145, 259-263.
14. Hattori, N., Shimatsu, A., Kato, Y., Koshiyama, H., Ishikawa, Y., Tanoh, T., Assadian, H. & Imura, H. (1989) Urinary excretion of human growth hormone: daily variation and relationship with albumin and alpha 1-microglobulin in urine. Acta Endocrinologica, 121, 533-537.
15. Hourd, P. & Edwards, R. (1989) Measurement of human growth hormone in urine: development and validation of a sensitive and specific assay. Journal of Endocrinology, 121, 167-175.
16. Hourd, P., Edge, J.A., Dunger, D.B., Dalton, N. & Edwards, R. (1991) Urinary growth hormone excretion during puberty in type I (insulin-dependent) diabetes mellitus. Diabetic Medicine, 8, 237-242.
17. Hourd, P. & Edwards, R. (1994) Current methods for the measurement of growth hormone in urine. Clinical Endocrinology, 40, 155-170.
18. Kida, K., Ito, T., Hayash, M., Goto, Y., Ikeuchi, M, & Matsuda, H. (1992) Urinary excretion of human growth hormone in children with short stature: correlation with pituitary secretion of human growth hormone. Journal of Pediatrics, 120, 233-237.
19. Kuhno, H., Murakami, Y. & Kodaira, T. (1990) Urinary human growth hormone measurement using a highly sensitive sandwich enzyme immunoassay: diagnostic and therapeutic uses in patients with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism, 71, 1496-1500.
20. Léger, J., Reverchon, C., Porquet, D., Noel, M. & Czernichow, P. (1995) The wide variation in urinary excretion of human growth hormone in normal growing and growth hormone deficient-children limits its clinical usefulness. Hormone Research, 44, 57-63.
21. Main, K., Philips, M., Jorgensen, M. & Skakkebaek, N.E. (1991) Urinary growth hormone excretion in 657 healthy children and adults: normal values, inter-and intra-individual variations. Hormone Research, 36, 174-182.
22. Main, K.M., Jarden, M., Angelo, L., Dinesen, B., Hertel, N.T., Juul, A., Muller, J. & Skakkebaek, N.E. (1994) The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of three morning urine sample in 517 healthy children and adults. Journal of Clinical Endocrinology and Metabolism, 79, 865-871.
23. Patel, L., Skinner, A.M., Price, D.A. & Clayton, P.E. (1994) The influence of body mass index on growth hormone secretion in normal and short slatured children. Growth Regulation, 4, 29-34.
24. Quabbe, H.J., Helge, H. & Kubicki, S. (1971) Nocturnal growth hormone secretion: correlation with sleeping EEG in adults and pattern in children and adolescents with non pituitary dwarfism, overgrowth and with obesity. Acta Endocrinologica, 67, 767-783.
25. Rolland-Cachera, M.F., Sempè, M., Guilloud-Bataille, M., Patois, E., Pequignot-Guggenbuhl, F. & Fautrad, V. (1982) Adiposity indices in children. American Journal of Clinical Nutrition, 36, 178-184.
26. Sartorio, A., Bochicchio, D., Morabito, F. & Faglia, G. (1989) Growth hormone responsiveness to GHRH in obese children before and after weight loss. Acad Paediatrica Scandinavica, 78, 329-330.
27. Sartorio, A., Conti, A. & Ferrero, S. (1996) Low urinary GH levels in normal statured obese children. Acta Paediatrica, 85, 894-898.
28. Stirling, H.F., Seth, J., Sturgeon, C.M., Barnes, S.I. & Kelnar, C.J.H. (1993) The relationship between overnight plasma growth hormone profiles and nocturnal urinary growth hormone excretion. Pediatric Research, 33 (Suppl,), S40.
29. Sukegawa, I., Hizuka, N., Takano, K., Asakawa, K., Horikawa, R., Hashida, S., Ishikawa, E., Mohri, Z., Murakami, Y. & Shizume, K. (1988) Urinary growth hormone (GH) measurements are useful tor evaluating endogenous GH secretion. Journal of Clinical Endocrinology and Metabolism, 66, 1119-1123.
30. Sukegawa, I., Hizuka, N., Takano, K., Asakawa, K., Horikawa, R., Hashida, S., Ishikawa, E., Mohri, Z., Murakami, Y. & Shizume, K. (1989) Measurement of nocturnal urinary growth hormone values. Acta Endocrinologica, 121, 290-296.
31. Tomita, H., Ogawa, M., Kamijo, T., Mori, O., Ishikawa, E., Mohri, Z. & Murakami, Y. (1989) Highly sensitive sandwich enzyme immunoassay of urinary growth hormone in children with short stature, Turner's syndrome, and simple obesity. Acta Endocrinologica, 121, 513-519.
32. Torresani, T. & Dinesen, B. (1991) GH assay in urine: evaluation of a commercial kit. In Growth Disorders: the State of the Art (eds. L. Cavallo, J.C. Job & M.I. New), pp. 91 98. Raven Press, New York.
33. Van Vliet, G., Bosson, D., Rummens, E., Robyn, C. & Woller, R. (1986) Evidence against growth hormone-releasing factor deficiency in children with idiopathic obesity. Acta Endocrinologica, 279 (Suppl.), 403-410.
34. Walker, J.M., Wood, P.J., Williamson, S., Betts, P.E. & Evans, A.J. (1990) Urinary growth hormone excretion as a screening test for growth hormone deficiency. Archives of Disease in Childhood, 65, 89-92.