Quantification of human herpesvirus 6 in healthy volunteers and patients with lymphoproliferative disorders by PCR-ELISA

Leukemia Research

Volumn 23, Issue 7, 1999, Pages 625-630

  Ohyashiki, Junko H ^a   Abe, Kenji ^a   Ojima, Tomoko ^a   Wang, Ping ^a   Zhou, Chang Fang ^a   Suzuki, Akitaka ^b   Ohyashiki, Kazuma ^b   Yamamoto, Kohtaro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Hematologic disease; HHV 6; Immunocompromized host; Quantification

Indexed keywords

PLASMID DNA; VIRUS DNA;

ADULT; AGED; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN HERPESVIRUS 6; IMMUNOBLASTIC LYMPHADENOPATHY; LEUKOCYTE; LYMPH NODE; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SCHOOL CHILD; T CELL LYMPHOMA; TECHNIQUE; VIRUS DETECTION; VIRUS LOAD;

ADULT; AGED; AGED, 80 AND OVER; CHILD; DNA, NEOPLASM; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOME, VIRAL; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; TUMOR STEM CELLS;

EID: 0033020720     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(99)00079-X     Document Type: Article

References (17)

1. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T. Idetification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1988;1:1065-7.
2. Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. New Engl J Med 1994;331:432-8.
3. Cone RW, Huang M-LW, Ashley R, Corey L. Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J Clin Microbiol 1993;31:1262-7.
4. Cone RW, Hackman R, Huang M-LW, Bowden RA, Meyers JD, Metcalf M, Zeh J, Ashley R, Corey L. Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. New Engl J Med 1993;329:156-61.
5. Wang F-Z, Dahl H, Linde A, Brytting M, Ehrnst A, Ljungman P. Lymphotropic herpesvirus in allogeneic bone marrow transplantation. Blood 1996;88:3615-20.
6. Lusso P, Gallo RC. Human herpesvirus 6 in AIDS. Immunol Today 1995;16:67-71.
7. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, Lusso P. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 1995;171:273-80.
8. Secchiero P, Zella D, Crowley RW, Gallo RC, Lusso P. Quantitative PCR for human herpesvirus 6 and 7. J Clin Microbiol 1995;33:2124-30.
9. Clark DA, Ait-Khaled M, Wheeler AC, Kidd M, McLaughlin JE, Johnson MA, Griffiths PD, Emery VC. Quantificaiton of human herpesvirus 6 in immunocompetent persons and postmortem tissues from AIDS patients by PCR. J Gen Virol 1996;77:2271-5.
10. Nicholas J, Martin MED. Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homolog and transactivating functions. J Virol 1994;68:597-610.
11. Pellett PE, Sanchez-Martinez D, Dominguez G, Black JB, Anton E, Greenamoyer C, Dambaugh TR. A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology 1993;195:521-31.
12. Zhou CF, Abe K, Wang P, Yamamoto K. Susceptibility of the adult T-cell leukemia (ATL) cell lines to HHV-6B. Leukemia 1998;12:1001.
13. Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Narni F, Mariano MT, Federico M, Ceccherini-Nelli L, Bendinelli M, Montagnani G, Montorsi M, Artusi T. Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood 1991;77:2251-8.
14. Valente G, Secchiero P, Lusso P, Abele MC, Jemma C, Reato G, Kerim S, Gallo RC, Palestro G. Human herpesvirus 6 and Ebstein-Barr virus in Hodgkin's disease: a controlled study by polymerase chain reaction and in situ hybridization. Am J Pathol 1996;149:1501-10.
15. Luka J, Pirruccello SJ, Kersey JH. HHV-6 genomes in T-cell acute lymphoblastic leukaemia. Lancet 1991;338:1277-8.
16. Barozzi P, Luppi M, Marasca R, Trovato R, Ceccherini-Nelli L, Torelli G. Human herpesvirus-6 genomes in acute lymphoblastic leukemia: evidence against an etiologic relationship. Acta Haematol 1995;94:169-72.
17. Daibata M, Taguchi T, Kamioka M, Kubonishi I, Taguchi H, Miyoshi I. Identificaiton of integrated human herpesvirus 6 DNA in early pre-B-cell acute lymphoblastic leukemia. Leukemia 1998;12:1002-4.