Human herpesvirus 6 and Epstein-Barr virus in Hodgkin's disease: A controlled study by polymerase chain reaction and in situ hybridization

American Journal of Pathology

Volumn 149, Issue 5, 1996, Pages 1501-1510

  Valente, Guido ^a   Secchiero, Paola ^b   Lusso, Paolo ^c   Abele, Maria Cristina ^a   Jemma, Cristina ^a   Reato, Gigliola ^a   Kerim, Simonetta ^a   Gallo, Robert C ^b   Palestro, Giorgio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ARTICLE; EPSTEIN BARR VIRUS; HODGKIN DISEASE; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

BLOTTING, SOUTHERN; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HERPESVIRUS 6, HUMAN; HODGKIN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION; TUMOR VIRUS INFECTIONS;

EID: 0029987332     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M, Halligan G, Biberfeld P, Wong-Staal F, Kramarsky B, Gallo RC: Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 1986, 234:596-601
2. Lusso P, Markham PD, Tschachler E, Di Marzo Veronese F, Salahuddin SZ, Ablashi DV, Pahwa S, Krohn K, Gallo RC: In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus 6). J Exp Med 1988, 167:1659-1670
3. Lopez C, Pellett P, Stewart J, Goldsmith C, Sanderlin K, Black J, Warfield D, Feorino P: Characteristics of human herpesvirus-6. J Infect Dis 1988, 157:1271-1273
4. Takahashi K, Sonoda S, Higashi K, Kondo T, Takahashi H, Takahashi M, Yamanishi K Predominant CD4T-lymphocyte tropism of human herpesvirus 6-related virus. J Virol 1989, 63:3161-3163
5. + mature T-cell populations and clones by HHV-6: transcriptional down-regulation of CD3. J Immunol 1991, 147:2147-2153
6. Ablashi DV, Josephs SF, Buchbinder A, Hellman K, Nakamura S, Llana T, Lusso P, Kaplan M, Dahlberg J, Memon S, Imam F, Ablashi KL, Markham PD, Kramarsky B, Krueger GRF, Biberfeld P, Wong-Staal F, Salahuddin SZ, Gallo RC: Human B- lymphotropic virus (human herpesvirus-6). J Virol Methods 1988, 21: 65-88
7. Kondo K, Kondo T, Okuno T, Takahashi M, Yamanishi K: Latent human herpesvirus 6 infection of human monocytes/macrophages. J Gen Virol 1991, 72:1401-1408
8. Luka J, Okano M, Thiele G: Isolation of human herpesvirus 6 from clinical specimens using human fibroblast cultures. J Clin Lab Anal 1990, 4:483-486
9. Lusso P, Gallo RC: Human herpesvirus 6 (HHV-6). Baillière's Clin Haematol 1995, 8:201-223
10. Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GR, Kramarsky B, Salahuddin SZ, Gallo RC: Genomic polymorphism, growth properties, and immunogenic variations in human herpesvirus-6 isolates. Virology 1991, 184:545-552
11. Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, Richard S, Huraux JM, Agut H: Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J Clin Microbiol 1991, 29:367-372
12. Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N: Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci USA 1991, 88:5922-5926
13. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T: Identification of human herpesvirus 6 as a causal agent for exanthema subitum. Lancet 1988, i:1065-1067
14. Akashi K, Eizuru Y, Sumiyoshi Y, Minematsu T, Hara S, Harada M, Kikuchi M, Niho Y, Minamishima Y: Severe infectious mononucleosis-like syndrome and primary human herpesvirus 6 infection in an adult N Engl J Med 1993, 329:168-171
15. Jarrett RF, Giedhill S, Qureshi F, Crae SH, Madhok R, Brown I, Evans I, Krajewski A, Q'Brien CJ, Cartwright RA, Venables P, Onions DE: Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin's lymphoma. Leukemia 1988, 2:496-501
16. Josephs SF, Buchbinder A, Streicher HZ, Ablashi DV, Salahuddin SZ, Guo HG, Wong-Staal F, Crossman J, Raffeld M, Sundeen J, Levine P, Biggar R, Gerhardt R, Krueger F, Fox RI, Gallo RC: Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients. Leukemia 1988, 2:132-135
17. Borisch B, Ellinger K, Neipel F, Fleckenstein B, Kirchner T, Ott MM, Muller-Hermelink HK: Lymphadenitis and lymphoproliferative lesions associated with the human herpes virus-6 (HHV-6). Virchows Arch B Cell Pathol 1991, 61:179-187
18. Fillet A-M, Raphael M, Visse B, Audouin J, Poirel L, Agut H, the French Study Group for HIV-Associated Tumors: Controlled study of human herpesvirus 6 detection in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma. J Med Virol 1995, 45:106-112
19. Luppi M, Marasca R, Barozzi P, Artusi T, Torelli G: Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Leuk Res 1993, 17:1003-1011
20. Kikuchi M, Sumiyoshi Y, Minamishima Y: Kikuchi's disease (histiocytic necrotizing lymphadenitis). Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology, Edited by DV Ablashi, GRF Krueger, SZ Salahuddin. Amsterdam, Elsevier Science Publishers, 1992, pp 175-184
21. Levine PH, Jahan N, Murari P, Manak M, Jaffe ES: Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J Infect Dis 1992, 166:291-295
22. Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Narni F, Mariano MT, Federico M, Ceccherini-Nelli L, Bendinelli M, Montagnani G, Montorsi M, Artusi T: Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction. Blood 1991, 77:2251-2258
23. MacLellan KA, Bennett MH, Tu A, Hudson BV, Easterling MJ, Hudson GV, Jelliffe AM: Relationship of histopathologic features to survival and relapse in nodular sclerosing Hodgkin's disease: a study of 1659 patients. Cancer 1989, 64:1686-1693
24. Ferry JA, Linggood RM, Convery KM, Efird JT, Eliseo R, Harris NL: Hodgkin disease, nodular sclerosis type: implications of histologic subclassification. Cancer 1993, 71:457-463
25. Josephs SF, Salahuddin SZ, Ablashi DV, Schachter F, Wong-Staal F, Gallo RC: Genomic analysis of the human B-lymphotropic virus. Science 1986, 234:601-603
26. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL, Gallo RC, Lusso P: Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 1995, 171:273-280
27. Saito I, Servenius B, Compson T, Fox RI: Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome. J Exp Med 1989, 169:2191-2198
28. Raab-Traub N, Flynn K: The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 1986, 47:883-889
29. Loughran TP Jr, Zambello R, Ashley R, Guderian J, Pellenz M, Semenzato G, Starkebaum G: Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. Blood 1993, 81:2723-2727
30. Bauer HM, Ting Y, Greer CE, Chambers JC, Tashiro CJ, Chimera J, Reingold A, Manos MM: Genital human papilloma virus infection in female university students as determined by a PCR-based method. JAMA 1991, 265:472-477
31. Hamilton-Dutoit SJ, Pallesen G: Detection of Epstein-Barr virus small RNAs in routine paraffin sections using non-isotopic RNA/RNA in situ hybridization. Histopathology 1994, 25:101-111
32. Hsu SM, Raine L: The use of avidin-biotin peroxidase complex (ABC) in diagnostic and research pathology. Advances in Immunohistochemistry. Edited by RA De Lellis. New York, Masson, 1984, p 31
33. Di Luca D, Dolcetti R, Mirandola P, De Re V, Secchiero P, Carbone A, Boiocchi M, Cassai E: Human herpesvirus 6: a survey of presence and variant distribution in normal peripheral lymphocytes and lymphoproliferative disorders. J Infect Dis 1994, 170:211-215
34. Horwitz CA, Beneke J: Human herpesvirus 6 revisited. Am J Clin Pathol 1993, 99:533-535
35. Cuende JI, Ruiz J, Civeira MP, Prieto J: High prevalence of HHV-6 DNA in peripheral blood mononuclear cells of healthy individuals detected by nested PCR. J Med Virol 1994, 43:115-118
36. Sumiyoshi Y, Kikuchi M, Ohshima K, Takeshita M, Eizuru Y, Minamishima Y: Analysis of human herpes virus-6 genomes in lymphoid malignancy in Japan. J Clin Pathol 1993, 46:1137-1138
37. Hollingsworth HC, Peiper SC, Weiss LM, Raffeld M, Jaffe ES: An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease: lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents. Arch Pathol Lab Med 1994, 118:134-140
38. Kelley PK, McClain KL: Respiratory contamination of polymerase chain reactions by human herpesvirus 6. Am J Hematol 1994, 47:325-327
39. Yin SY, Ming HA, Jahan N, Manak M, Jaffe ES, Levine PH: In situ hybridization detection of human herpesvirus 6 in biopsy specimens from Chinese patients with non-Hodgkin's lymphoma. Arch Pathol Lab Med 1993, 117:502-506
40. Levine PH, Neequaye J, Yadav M, Connelly R: Geographic/ethnic differences in human herpesvirus-6 antibody patterns. Microbiol Immunol 1992, 36:169-172
41. Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J: Epstein-Barr viral DNA in tissues of Hodgkin's disease. Am J Pathol 1987, 129:86-91
42. Staal SP, Ambinder R, Beschorner WE, Hayward GS, Mann R: A survey of Epstein-Barr virus DNA in lymphoid tissue: frequent detection in Hodgkin's disease. Am J Clin Pathol 1989, 91:1-5
43. Herbst H, Niedobitek G, Kneba M, Hummel M, Finn T, Anagnostopoulos I, Bergholz M, Krieger G, Stein H: High incidence of Epstein-Barr virus genomes in Hodgkin's disease. Am J Pathol 1990, 137:13-18
44. Weiss LM, Chen YY, Liu XF, Shibata D: Epstein-Barr virus and Hodgkin's disease: a correlative in situ hybridization and polymerase chain reaction study. Am J Pathol 1991, 139:1259-1265
45. Brousset P, Meggetto F, Chittal S, Bibeau F, Arnaud J, Rubin B, Delsol G: Methods in laboratory investigation assessment of the methods for the detection of Epstein-Barr virus nucleic acids and related gene products in Hodgkin's disease. Lab Invest 1993, 69:483-490
46. Ohshima K, Kikuchi M, Eguchi F, Masuda Y, Sumiyoshi Y, Mohtai H, Takeshita M, Kimura N: Analysis of Epstein-Barr viral genomes in lymphoid malignancy using Southern blotting, polymerase chain reaction, and in situ hybridization. Virchows Arch B Cell Pathol 1990, 59:383-390
47. Ambinder RF, Browning PJ, Lorenzana I, Leventhal BG, Cosenza H, Mann RB, MacMahon EME, Medina R, Cardona V, Grufferman S, Olshan A, Levin A, Petersen EA, Blattner W, Levine PH: Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 1993, 81:462-467
48. Chang KL, Albjar PF, Chen Y-Y, Johnson RM, Weiss LM: High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin's disease occurring in Peru. Blood 1993, 81:496-501
49. Masih A, Weisenburger D, Duggan M, Armitage J, Bashir R, Mitchell D, Wickert R, Purtilo DT: Epstein-Barr viral genome in lymph nodes from patients with Hodgkin's disease may not be specific to Reed-Sternberg cells. Am J Pathol 1991, 139:37-43
50. Razzaque A: Oncogenic potential of human herpesvirus-6 DNA. Oncogene 1990, 5:1365-1370
51. Levine PH, Ebbesen P, Ablashi DV, Saxinger WC, Nordentoft A, Connelly RR: Antibodies to human herpes virus-6 and clinical course in patients with Hodgkin's disease, Int J Cancer 1992, 51:53-57
52. Flamand L, Stefanescu I, Ablashi DV, Menezes J: Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6. J Virol 1993, 67:6768-6777
53. Flamand L, Gosselin J, D'Addario M, Hiscott J, Ablashi DV, Gallo RC, Menezes J: Human herpesvirus 6 induces interleukin-1β and tumor necrosis factor-a, but not interleukin-6, in peripheral blood mononuclear cell cultures. J Virol 1991, 65:5105-5110
54. Strauchen JA, Breakstone BA: IL-2 receptor expression in human lymphoid lesions: immunohistochemical study of 166 cases. Am J Pathol 1987, 126:1506-1512
55. Tesch H, Gunther A, Abts H, Jucker M, Klein S, Krueger GR Diehl V: Expression of interleukin-2Rα and interleukin-2Rβ in Hodgkin's disease. Am J Pathol 1993, 142:1714-1720