Growth inhibitory effect of L-canavanine against MIA PaCa-2 pancreatic cancer cells is not due to conversion to its toxic metabolite canaline

Anti-Cancer Drugs

Volumn 10, Issue 1, 1999, Pages 113-118

  Swaffar, Diane Shomin ^a   Ang, Choo Yaw ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Arginase; Canaline; Canavanine; MIA PaCa 2; Pancreatic cancer

Indexed keywords

ARGINASE; CANAVANINE;

ARTICLE; CANCER CELL; CYTOTOXICITY; GROWTH INHIBITION; PRIORITY JOURNAL; RADIOMETRY;

EID: 0033019736     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199901000-00014     Document Type: Article

References (17)

1. Rosenthal GA. Plant nonprotein amino and imino acids: biological, biochemical, and toxicological properties. New York Academic Press 1982.
2. Swaffar DS, Ang CY, Desai PB, Rosenthal GA. Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine. Cancer Res 1994; 54: 6045-8.
3. Swaffar DS, Ang CY, Desai PB, et al. Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies. Anti-Cancer Drugs 1995; 6: 586-93.
4. 14C]-canavanine in the rat. Toxicol Appl Pharmacol 1987; 91: 406-14.
5. Rosenthal GA. L-Canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci 1997; 60: 1635-41.
6. Thomas DA, Rosenthal GA. Toxicity and pharmacokinetics of the nonprotein amino acid L-canavanine in the rat. Taxicol Appl Pharmacol 1987; 91: 395-405.
7. Cann SA, van Netten JP, Ross AS. Correspondence re: D. S. Swaffar et al. Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine. Cancer Res 1995; 55: 4486-7.
8. Malaisse WJ, Blachier F, Mourtada A, et al. Stimulussecretion coupling of arginine-induced insulin release: metabolism of L-arginine and L-ornithine in tumoral islet cells. Mol Cell Endocrinol 1989; 67: 81-91.
9. Rosenthal GA, Thomas DA. A radiometric assay for determining the incorporation of L-canavanine or L-arginine into protein. Anal Biochem 1985; 147: 428-31.
10. Ozinskas AJ, Rosenthal GA. L-Canavanine synthesis by zinc-mediated guanidination of L-canaline with cyanamide. Bioorg Chem 1986; 14: 157-62.
11. Spector EB, Kern RM, Haggerty DF, Cederbaum SD. Differential expression of multiple forma of arginase in cultured cells. Mol Cell Biochem 1985; 66: 45-53.
12. Grody WW, Dizikes GJ, Cederbaum SD. Human arginase isozymes. Isozymes Curr Top. Biol Med Res 1987; 13: 181-214.
13. Michelangeli C, Vargas RE. L-Canavanine influences feed intake, plasma basic amino acid concentrations and kidney arginase activity in chickens. J Nutr 1994; 124: 1081-7.
14. Rosenthal GA, Lambert J, Hoffmann D. Canavanine incorporation into the antibacterial proteins of the fly, Phormia terranovae (Diptera), and its effect on biological activity. J Biol Chem 1989; 264: 9768-71.
15. Rosenthal GA, Dahlman DL. Studies of L-canavanine incorporation into insectan lysozyme. J Biol Chem 1991; 266: 15684-7.
16. Rosenthal GA, Dahlman DL. Incorporation of L-canavanine into proteins and the expression of its antimetabolic effects. J Food Agric Chem 1991; 39: 987-90.
17. Gonzalez DE, Covitz KY, Sadee W, Mrsny RJ. An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Cancer Res 1998; 58: 519-25.