Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 3, 1999, Pages 683-685

  Wang, Ge ^a   Rahman, M Sayeedur ^b   Humayun, M Zafri ^b   Taylor, Diane E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARITHROMYCIN; RNA 23S;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIUM MUTANT; HELICOBACTER PYLORI; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

EID: 0033016657     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.3.683     Document Type: Article

References (16)

1. Cayla, R., F. Zerbib, P. Talbi, F. Megraud, and H. Lamouliatte. 1995. Pre- and posttreatment clarithromycin resistance of Helicobacter pylori strains: a key factor of treatment failure. Gut 37(Suppl. 1):A55.
2. Debets-Ossenkopp, Y. J., A. B. Brinkman, E. J. Kuipers, C. M. J. E. Vandenbroucke-Grauls, and J. G. Kusters. 1998. Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori. Antimicrob. Agents Chemother. 42:2749-2751.
3. Debets-Ossenkopp, Y. J., M. Sparrius, J. G. Kusters, J. J. Kolkman, and C. M. J. E. Vandenbroucke-Grauls. 1996. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori. FEMS Microbiol. Lett. 142:37-12.
4. Goddard, A. F., and R. P. H. Logan. 1996. Antimicrohiol resistance and Helicobacter pylori. J. Antimicrob. Chemother. 37:639-643.
5. Occhialini, A., M. Urdaci, F. Doucet-Populaire, C. M. Bebear, H. Lamouliatte, and F. Megraud. 1997. Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to rihosomes. Antimicrob. Agents Chemother. 41:2724-2728.
6. Palejwala, V. A., R. W. Rzepka, D. Simha, and M. Z. Humayun. 1993. Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA. Biochemistry 32:4105-4111.
7. Rahman, M. S., P. M. Dunman, G. Wang, H. S. Murphy, and M. Z. Humayun. 1996. Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions. Mol. Microbiol. 22:747-755.
8. Rene, W. M., V. D. Hulst, J. J. Keller, E. A. J. Rauws, and G. N. J. Tytgat. 1996. Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter 1:6-19.
9. Stone, G. G., D. Shortridge, J. Versalovic, J. Beyer, R. K. Flamm, A. T. Ghoneim, and K. Tanaka. 1997. A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori. Antimicrob. Agents Chemother. 41:712-714.
10. Stone, G. G., D. Shortridge, R. K. Flamm, J. Versalovic, J. Beyer, K. Idler, L. Zulawinski, and K. Tanaka. 1996. Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori. Helicobacter 1:227-228.
11. Taylor, D. E., Z. Ge, D. Purvch, T. Lo, and K. Hiratsuka. 1997. Cloning and sequence analysis of the two copies of 23S rRNA genes from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. Antimicrob. Agents Chemother. 41:2621-2628.
12. Vaira, D., J. Holton, M. Miglioli, M. Menegatti, P. Mule, and L. Barbara. 1994. Peptic ulcer disease and Helicobacter pylori infection. Curr. Opin. Gastroenterol. 10:98-104.
13. Versalovic, J., D. Shortridge, K. Kibler, M. V. Griffy, J. Bryer, R. K. Flamm, S. K. Tanaka, D. Y. Graham, and M. F. Go. 1996. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 40:477-480.
14. Versalovic, J., M. S. Osato, K. Spakovsky, M. P. Dore, R. Reddy, G. G. Stone, D. Shortridge, R. K. Flamm, S. K. Tanaka, and D. Y. Graham. 1997. Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. J. Antimicrob. Chemother. 40: 283-286.
15. Wang, G., and D. E. Taylor. 1998. Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolidelincosamide-streptogramin B antibiotics. Antimicrob. Agents Chemother. 42:1952-1958.
16. Wang, G., V. A. Palejwala, P. M. Dunman, D. H. Aviv, H. S. Murphy, M. S. Rahman, and M. Z. Humayun. 1995. Alkylating agents induce UVM, a recA-independent inducible mutagenic phenomenon in Escherichia coli. Genetics 141:813-823.