Investigation on SCH00013, a novel cardiotonic agent with Ca++ sensitizing action: 2nd Communication: In vivo cardiovascular effects and bioavailability in dogs

Arzneimittel-Forschung/Drug Research

Volumn 49, Issue 5, 1999, Pages 407-411

  Yoshimura, Akira ^a   Koide, Yuji ^a   Yoshioka, Komitomo ^a   Hino, Masataka ^a   Sugawara, Hiromi ^a   Sakato, Mitsuo ^a   Endoh, Masao ^b  

^a ZENYAKU KOGYO CO LTD   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

Author keywords

4,5 Dihydro 6 1 2 hydroxy 2 (4 cyanophenyl)ethyl 1,2,5,6 tetrahydropyrido 4 yl pyridazin 3(2H) one; Cardiotonic agent; SCH00013, bioavailability, cardiovascular effects, dog

Indexed keywords

4,5 DIHYDRO 6 [1 [2 HYDROXY 2 (4 CYANOPHENYL)ETHYL] 1,2,5,6 TETRAHYDROPYRIDO 4 YL]PYRIDAZIN 3(2H) ONE; 4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; AMRINONE; CALCIUM SENSITIZER; CARDIAC GLYCOSIDE; CARDIOTONIC AGENT; CATECHOLAMINE; ENOXIMONE; IMAZODAN; LEVOSIMENDAN; MILRINONE; PIMOBENDAN; PIPERANOMETOZINE; PYRIDAZINE DERIVATIVE; SULMAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONGESTIVE HEART FAILURE; DOG; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG RESEARCH; HEART LEFT VENTRICLE PRESSURE; INOTROPISM; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION;

EID: 0033016281     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300435     Document Type: Article

References (30)

1. Farah, A. E., Alousi, A. A., Schwarz, R. P. Jr., Annu. Rev. Pharmacol. Toxicol. 24, 275 (1984)
2. Packer, M., J. Am. Coll. Cardiol. 22 (Suppl. A), 119A (1993)
3. Likoff, M. J., Weber, K. T., Andrews, V. et al., J. Am. Coll. Cardiol. 3, 1282 (1984)
4. Packer, M., Carver, J. R., Rodenheffer, R. J. et al., N. Engl. J. Med. 325, 1467 (1991)
5. Uresky, B. F., Jessup, M., Konstam, M. A. et al., Circulation 82, 774 (1990)
6. Goldberg, A. D., Goldstein, S., Nicklas, J., Circulation 82 (Suppl. III), III673 (1990)
7. Feldman, A. M., Young, J., Bourge. R. et al., J. Am. Coll. Cardiol. 29 (Suppl. A), 64A (1997)
8. Feldman, A. M., Bristow, M. R., Parmely, W. W. et al., N. Engl. J. Med. 329, 149 (1993)
9. Katz, A. M., Circulation 73 (Suppl. III), III184 (1986)
10. Nielsen-Kudsk, J. E., Aldershvile, J., J. Cardiovasc. Pharmacol. 26 (Suppl. A), S77 (1995)
11. Endoh, M., in: New Horizons for Failing Heart Syndrome, S. Sasayama (ed.), pp. 187, Springer-Verlag, Tokyo (1996)
12. Hajar, R. J., Schmidt, U., Helm, P. et al., J. Pharmacol. Exp. Ther. 280, 247 (1997)
13. Végh, Á., Papp, J. Gy., Udvary, É. et al., J. Cardiovasc. Pharmacol. 26 (Suppl. I), S21 (1995)
14. Asanoi, H., Ishizaka, S., Kameyama, T. et al., J. Cardiovasc. Pharmacol. 23, 268 (1994)
15. Abe, Y., Kitada, Y., Narimatsu, A., J. Pharmacol. Exp. Ther. 256, 819 (1993)
16. Pouleur, H., Rousseau, M. F., van Mechelen, H. et al., J. Cardiovasc. Pharmacol. 4, 409 (1982)
17. Udvary, É., Papp, J. Gy., Mester, L. et al., J. Mol. Cell. Cardiol. 25 (Suppl. I), S18 (1993)
18. Sugawara, H., Endoh, M., J. Pharmacol. Exp. Ther. 287, 214 (1998)
19. Hino, M, Sugawara, H., Yoshimura, A. et al., Arzneim.-Forsch./Drug Res. 49 (I), 398 (1999)
20. Brunkhorst, M., v. der Leyen, H., Meyer, W., Naunyn-Schmiederbergs. Arch. Pharmacol. 339, 575 (1989)
21. Nankervis, R., Lues, I., Brown, L., J. Cardiovasc. Pharmacol. 24, 612 (1994)
22. Honeräger, P., Klockow, M., Schönsteiner, G. et al., J. Cardiovasc. Pharmacol. 13, 673 (1989)
23. Boknik, M., Neumann, J., Kaspareit, G. et al., J. Pharmacol. Exp. Ther. 280, 277 (1997)
24. Nishimura, M., Sato, N., Tanaka, H. et al., Circulation 82 (Suppl. III), III527 (1990)
25. Tande, P., Bjornstad, H., Yang, T. et al., J. Cardiovasc. Pharmacol. 16, 401 (1990)
26. Spinelli, W., Parsons, W., Colatsky, T. J., J. Cardiovasc. Pharmacol. 20, 913 (1992)
27. Wallace, A. A., StupienskiIII, R. F., Brookes, L. M. et al., J. Cardiovasc. Pharmacol. 18, 687 (1991)
28. Katz, A. M., Circulation 47, 1076 (1973)
29. Katz, A. M., N. Engl. J. Med. 322, 100 (1990)
30. Baskin, E. P., Serik, C. M., Wallace, A. A. et al., J. Cardiovasc. Pharmacol. 18, 406 (1991)