Antigen binding characteristics of experimentally-induced antibodies against hydroxyl radical modified native DNA

Autoimmunity

Volumn 29, Issue 1, 1999, Pages 11-19

  Ashok, Badithe T ^a   Ali, Rashid ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Anti DNA antibodies; Hydroxyl radical; Reaotive oxygen species; ROS DNA; Systemic lupus erythematosus

Indexed keywords

DNA ANTIBODY; HYDROXYL RADICAL; THYMINE;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CATTLE; DNA STRAND BREAKAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; NONHUMAN; THYMUS; ULTRAVIOLET IRRADIATION;

EID: 0032979458     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908995968     Document Type: Article

References (52)

1. Tan, E.M. Autoantibody to nuclear antigens (ANA): their immunobiology and medicine. Adv. Immunol. 1982; 33: 167-240.
2. Stollar, B.D. Immunochemical analysis of nucleic acids. Prog. Nucleic Acid Res. Mol. Biol. 1992; 42: 39-77.
3. Pisetsky, D.S., Grudier, J.P. and Gilkeson, G.S. A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. Arth. Rheum. 1990; 33: 153-159.
4. Stollar, B.D. Antibodies to DNA. CRC Crit. Rev. Biochem. 1986; 20: 1-36.
5. Stollar, B.D. Immunochemistry of DNA. Int. Rev. Immunol. 1989; 5: 1-22.
6. Arif, Z. and Ali, R. Antigenicity of poly(dA-dT)-poly(dA-dT) photocrosslinked with 8-methoxypsoralen. Arch. Biochem. Biophys. 1996; 329: 191-198.
7. Arjumand, S., Arif, Z., Ali, A. and Ali, R. Native DNA fragments photocrosslinked to psoralen binds to anti-B and anti-Z DNA antibodies. Immunol. Lett. 1995; 48: 215-219.
8. Moinuddin, and Ali, A. SLE anti-DNA autoantibodies binding estradiol-albumin-DNA conjugate. Lupus 1994; 3: 43-46.
9. Burlingame, R.W., Doey, M.L., Starkebaum, G. and Rubin, R.L. The central role of chromatin in autoimmune responses to histone and DNA in systemic lupus erythematosus. J. Clin. Invest. 1994; 94: 184-193.
10. Bockenstedt, L.K., Gee, R. and Mamula, M.J. Self peptides in the initiation of lupus autoimmunity. J. Immunol. 1995; 154: 3516-3524.
11. Mamula, M.J. Lupus autoimmunity: From peptides to particles. Immunol. Rev. 1995; 144: 301-314.
12. Zack, D.J., Yamamoto, K., Wong, A.L., Stempniak, M., French, C. and Weisbart, R.H. DNA mimicks a self protein that may be a target for some anti-DNA antibodies in systemic lupus erythematosus. J. Immunol. 1995; 154: 1987-1994.
13. Lunec, J., Griffiths, H.R. and Blake, D.R. Oxygen free radicals in inflammation. ISI Sci. Atlas 1987; 1: 45-58.
14. Ames, B.N, and Gold, L.S. Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 1991; 250: 3-6.
15. Halliwell, B. and Gutteridge, J.M.C. In: Free Radicals in Biology and Medicine. 2nd edition, Oxford: Clarendon Press, 1989.
16. Aruoma, O.I., Halliwell, B., Gajewski, E. and Dizdaroglu, M. Copper-iron dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem. J. 1991; 273: 2601-2604.
17. 2 or irradiation is dependent on the mechanism of •OH radical production. Br. J. Cancer 1988; 58: 34-37.
18. Dizdaroglu, M. In: Halliwell, B. and Aruoma, O.I., eds. DNA and Free Radicals. Chichester: Ellis Horwood, 1993; pp. 19-39.
19. Olinski, R., Zastawny, T., Budzbon, J., Skokowski, J., Zegarski, W. and Dizdaroglu, M. DNA base modification in chromatin of human cancerous tissues. FEBS Lett. 1992; 309: 193-198.
20. Freeman, B.D. In: Armstrong, D., Sohal, R.S., Cutler, R.G. and Slater, T.E., eds. Free Radicals Molecular Biology, Aging and Disease. New York: Raven Press, 1984; pp. 43-52.
21. Alam, K. and Ali, R. The effect of hydroxyl radical on the antigenicity of native DNA. FEBS Lett. 1993; 319: 66-70.
22. Ara, J., Ali, A. and Ali, R. Antibodies against free radical modified native DNA recognize B-conformation. Immunol. Invest. 1992; 21: 553-563.
23. Ara, J. and Ali, R. Polynucleotide specificity of anti-reactive oxygen species (ROS) DNA antibodies. Clin. Exp. Immunol. 1993; 94: 134-139.
24. Ara, J. and Ali, R. Reactive oxygen species modified DNA of varying size are the preferred antigen for human anti-DNA autoantibodies. Immunol. Lett. 1992; 34: 195-200.
25. Blount, S., Griffiths, H., Emery, P. and Lunec, J. Reactive oxygen species modify human DNA, eliciting a more discriminating antigen for the diagnosis of systemic lupus erythematosus. Clin. Exp. Immunol. 1990; 81: 384-389.
26. Ali, R., DerSimonian, H. and Stollar, B.D. Binding of monoclonal anti-native DNA autoantibodies to DNA of varying size and conformation. Mol. Immunol. 1985; 22: 1415-1422.
27. Hasan, R. and Ali, R. Antibody recognition of common epitopes on Z-DNA and native DNA brominated under high salt. Biochem. Int. 1990; 20: 1077-1088.
28. Dardalhon, M. and Averback, D. Induction and removal of DNA interstrand crosslinks in V-79 Chinese hamster cells measured by hydroxyapatite chromatography after treatment with bifunctional furocoumarins. Int. J. Radiat. Biol. 1988; 54: 1007-1020.
29. Ali, R. and Sauerbier, W. Effects of ultraviolet irradiation and postirradiation incubation on heterogenous nuclear RNA size in murine cells. Biophys. J. 1978; 22: 393-411.
30. Ishaq, M. and Ali, R. Identical specificity of lupus antibodies and antibodies elicited in rabbits against Sm and RNP antigens. Immunol. Commun. 1984; 13: 447-455.
31. Aotsuka, S., Okawa, M., Ikebe, K. and Yokohari, R. Measurement of double stranded DNA antibodies in major immunoglobulin classes. J. Immunol. Methods 1979; 28: 149-162.
32. Sanford, D.G., Kotkow, K.J. and Stollar, B.D. Immunochemical detection of multiple conformations within a 36 base pair oligonucleotide. Nucleic Acids Res. 1979; 16: 10643-10655.
33. Fraga, C.G., Shigenaga, M.K., Park, J.W., Degan, P. and Ames, B.N. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine. Proc. Natl. Acad. Sci. USA 1990; 87: 4533-4537.
34. Breen, A.P. and Murphy, J.A. Reactions of oxyl radicals with DNA. Free Radic. Biol. Med. 1995; 18: 1033-1077.
35. Halliwell, B. and Aruoma, O.I. DNA damage by oxygen-derived species. FEBS Lett. 1991; 281: 9-19.
36. Stollar, B.D. Anti-DNA antibodies. Clin. Immunol. Allergy 1981; 1: 243-260.
37. Blount, S., Griffiths, H. and Lunec, J. Reactive oxygen species induce antigenic changes in DNA. FEBS Lett. 1989; 245: 100-104
38. Thomas, R. The denaturation of DNA. Gene 1993; 135: 77-79.
39. Mello-Filho, A.C. and Meneghini, R. In vivo formation of single strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction. Biochim. Biophys. Acta 1984; 781: 56-63.
40. Meneghini, R. Genotoxicity of active oxygen species in mammalian cells. Mutat. Res. 1988; 195: 215-230.
41. Hutchinson, F. Chemical changes induced in DNA by ionizing radiation. Prog. Nucleic Acid Res. Mol. Biol. 1985; 32: 115-154.
42. Yamamoto, K. and Kawanishi, S. Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper(II) ion and hydrogen peroxide. J. Biol. Chem. 1989; 264: 15435-15440.
43. 2 alone or with UVB or UVA irradiation. Photochem. Photobiol. 1996; 64: 117-122.
44. Lafer, E.M., Rauch, J., Andrzejewski, C.Jr., Mudd, D., Furie, A., Furie, B., Schwartz, R.S. and Stollar, B.D. Poly-specific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. 1981; 153: 897-909.
45. Rauch, J., Massicotte, H. and Tannenbaum, H. Hybridoma anti-DNA autoantibodies from patients with rheumatoid arthritis and systemic lupus erythematosus demonstrate similar nucleic acid binding characteristics. J. Immunol. 1985; 134: 180-186.
46. Ahmad, J., Ashok, B.T. and Ali, R. Reactive oxygen species modified thymine and poly(dT) present unique epitopes for human anti-DNA autoantibodies. Immunol. Lett. 1997; 58: 69-74.
47. Lunec, J., Herbert, K.E., Blount, S., Griffiths, H.R. and Emery, P. 8-Hydroxydeoxyguanosine: A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett. 1994; 348: 131-138.
48. Cooke, M.S., Mistry, N., Wood, C., Herbert, K.E. and Lunec, J. Immunogenicity of DNA damaged by reactive oxygen species - Implications for anti-DNA antibodies in lupus. Free Radic. Biol. Med. 1997; 22: 151-159.
49. Hardin, J.A. The lupus autoantigens and the pathogenesis of SLE. Arthritis Rheum. 1986; 29: 457-461.
50. Klinman, D.M. and Steinberg, A.D. Inquiry into murine and human lupus. Immunol. Rev. 1995; 144: 157-193.
51. Frenkel, K., Karkoszka, J., Kim, E. and Teoli, E. Recognition of oxidised DNA bases by sera of patients with inflammatory diseases. Free Radic. Biol. Med. 1993; 14: 483-494.
52. Diamond, B , Katz, J.B., Paul, E., Aranow, C., Lustgarten, D. and Scharff, M.D. The role of somatic mutation in the pathogenic anti-DNA response. Anna. Rev. Immunol. 1992; 10: 731-757.