Regulation of the murine NMDA-receptor-subunit NR2C promoter by Sp1 and fushi tarazu factor1 (FTZ-F1) homologues

European Journal of Neuroscience

Volumn 11, Issue 6, 1999, Pages 2083-2092

  Pieri, Isabelle ^a   Klein, Matthias ^a   Bayertz, Christian ^a   Gerspach, Jeannette ^a   Van Ploeg, Anja Der ^a   Pfizenmaier, Klaus ^a   Eisel, Ulrich ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

5' Untranslated region; Cell type specific expression; Gene regulation; NMDAR2C ( 3); Orphan nuclear hormone receptor; Transcription factors

Indexed keywords

BETA GALACTOSIDASE; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR; CIS ACTING ELEMENT; DNA BINDING PROTEIN; FUSHI TARAZU FACTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; STEROIDOGENIC FACTOR 1; TRANS ACTING FACTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; DNA TRANSFECTION; GEL MOBILITY SHIFT ASSAY; MOLECULAR CLONING; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RECEPTOR GENE; REPORTER GENE; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CELL LINE; CULTURE TECHNIQUES; DNA-BINDING PROTEINS; FUSHI TARAZU TRANSCRIPTION FACTORS; GENE EXPRESSION; HOMEODOMAIN PROTEINS; ISOMERISM; LAC OPERON; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, N-METHYL-D-ASPARTATE; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 0033012990     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00629.x     Document Type: Article

References (22)

1. Alam, J. & Cook, J.L. (1990) Reporter genes: application to the study of mammalian gene transcription. Anal. Biochem., 188, 245-254.
2. Bourguignon, J.P., Gerard, A., Purnelle, G., Czajkowski, V., Yamanaka, C., Lemaitre, M., Rigo, J.M., Moonen, G. & Franchimont, P. (1997) Duality of glutamatergic and GABAergic control of pulsatile GnRH secretion by rat hypothalamic explants: I. effects of antisense oligodeoxynucleotides using explants including or excluding the preoptic area. J. Neuroendocrinol., 9, 183-191.
3. Cooney, A.J., Tsai, S.Y., O'Malley, B.W. & Tsai, M.-J. (1992) Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol. Cell. Biol., 12, 4153-4163.
4. Dynan, W. & Tjian, R. (1985) Control of eucaryotic messenger RNA sythesis by sequence-specific DNA-binding protein. Nature, 316, 774-778.
5. Farrant, M., Feldmeyer, D., Takahashi, T. & Cull-Candy, S.G. (1994) NMDA-receptor channel diversity in the developing cerebellum. Nature, 368, 335-339.
6. Gazzaeley, A.H., Weiland, N.G., McEwen, B.S., Morrison, J. & H. (1996) Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. J. Neurosci., 16, 6830-6838.
7. Hollmann, M. & Heinemann, S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci., 17, 31-108.
8. Honda, S., Morohashi, K., Nomura, M., Takeya, H., Kitajima, M. & Omura, T. (1993) Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J. Biol. Chem., 268, 7494-7502.
9. Ikeda, Y., Lala, D.S., Luo, X., Kim, E., Moisan, M.-P. & Parker, K.L. (1993) Characterization of the mouse FTZ-F1 gene, which encodes an essential regulator of steroid hydroxylase gene expression. Mol. Endocrinol., 7, 852-860.
10. Ikeda, Y., Luo, X., Abbud, R., Nilson, J.H. & Parker, K.L. (1995) The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol. Endocrinol., 9, 478-487.
11. Ikeda, Y., Shen, W.H., Ingraham, H.A. & Parker, K.L. (1994) Developmental expression of mouse steroidogenic factor 1, an essential regulator of the steroid hydroxylases. Mol. Endocrinol., 8, 654-662.
12. Ingraham, H.A., Lala, D.S., Ikeda, Y., Luo, X., Shen, W.-H., Nachtigal, M.W., Abbud, R., Nilson, J.H. & Parker, K.L. (1994) The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev., 8, 2302-2312.
13. Irwin, R.P., Lin, S.Z., Rogawsky, M.A., Purdy, R., H., Paul, S. & M. (1994) Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: Structure activity studies. J. Pharmacol. Exp. Ther., 271, 677-682.
14. Ishida, N., Matsui, M., Mitsui, Y. & Mishina, M. (1994) Circadian expression of NMDA receptor mRNAs, epsilon 3 and zeta 1, in the suprachiasmatic nucleus of rat brain. Neurosci. Lett., 166, 211-215.
15. Kadonaga, J.T., Jones, K.A. & :and Tjian, R. (1986) Promoter-specific activation of RNA polymerase II transcription by Spl. Trends Biochem., 11, 20-23.
16. Kadowaki, Y., Toyoshima, K. & Yamamoto, T. (1995) Dual transcription control by Ear3/COUP: Negative regulation through the DR1 direct repeat and positive regulation through a sequence downstream of the transcriptional start site of the mouse mammary tumor virus promoter. Procl. Natl Acad. Sei. USA, 92, 4432-4436.
17. Klein, M., Pieri, I., Uhlmann, F., Pfizenmaier, K. & Eisel, U. (1998) Cloning and caracterization of promoter and 5′-UTR of the NMDA receptor subunit ε2: Evidence for alternative splicing of 5′-non-coding exon. Gene, 208, 259-269.
18. Kutsuwada, T., Kashiwabuchi, N., Mori, H., Sakimura, K., Kushya, E., Araki, K., Meguro, H., Masaki, H., Kumanishi, T., Arakawa, M. & Mishina, M. (1992) Molecular diversity of the NMDA receptor channel. Nature, 358, 36-41.
19. Lala, D., Rice, S., D.A. & Parker, K.L. (1992) Steroidogenic factor 1, a key regulator of Steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Molec. Endocrinol., 6, 1249-1258.
20. Leone, T., Cresci, S., Carter, ME., Zhang, Z., Lala, D.S., Strauss, A. & Kelly, D.P. (1995) The human medium chain Acyl-CoA Dehydrogenase Gene Promoter consists of a complex arrangement of nuclear receptor response elements and Spl binding sites. J. Biol. Chem., 270, 16308-16314.
21. Lopes da Silva, S. & Burbach, J.P.H. (1995) The nuclear hormone-receptor family in the brain: classics and orphans. Trends Neurosci., 18, 542-548.
22. Malik, S. & Karathanasis, S. (1995) Transcription activation by the orphan nuclear receptor ARP-1. Nucl. Acids Res., 23, 1536-1543.