Duality of glutamatergic and gabaergic control of pulsatile GnRH secretion by rat hypothalamic explants: I. Effects of antisense oligodeoxynucleotides using explants including or excluding the preoptic area

Journal of Neuroendocrinology

Volumn 9, Issue 3, 1997, Pages 183-191

  Bourguignon, Jean Pierre ^a   Gérard, Arlette ^a   Purnelle, Gentiane ^a   Czajkowski, Vincent ^a   Yamanaka, Chutaro ^a   Lemaître, Marc ^b   Rigo, Jean Michel ^a   Moonen, Gustave ^a   Franchimont, Paul ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b EUROGENTEC S A   (Belgium)

Author keywords

GABA; GnRH; NMDA; Oligodeoxynucleotides; Puberty

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUTAMIC ACID; GONADORELIN; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPLANT; GABAERGIC SYSTEM; GONADORELIN RELEASE; HYPOTHALAMUS; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TIME;

EID: 0030894884     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1997.00567.x     Document Type: Article

References (56)

1. Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 1980; 36: 53-88.
2. Martinez de la Escalera G, Choi ALH, Weiner RI. Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 1992; 89: 1852-1855.
3. Wetsel WC, Valenç MM, Merchenthaler I, Liposits Z, Lopez FJ, Weiner RI, Mellon PL, Negro-Vilar A. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci USA 1992; 89: 4149-4153.
4. Ronnekleiv OK, Naylor BR, Bond CT, Adelman JP. Combined immunohistochemistry for Gonadotropin-releasing hormone (GnRH) and Pro-GnRH, and in situ hybridization for GnRH messenger ribonucleic acid in rat brain. Molec Endocr 1989; 3: 363-371.
5. Purnelle G, Czajkowski V, Gérard A, Bourguignon JP. Sécrétion pulsatile de GnRH par des explants hypothalamiques de rat en l'absence de corps cellulaires et de mRNA du GnRH. XXIVe Colloque de la Société de Neuroendocrinologie Expérimentale, Québec. Annales d'Endocr 1995; 56: 449.
6. Bourguignon JP, Franchimont P. Puberty-related increase in episodic LHRH release from rat hypothalamus in vitro. Endocrinology 1984; 114: 1941-1943.
7. Bourguignon JP, Gérard A, Mathieu J, Mathieu A, Franchimont P. Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty: I. Increased activation of N-methyl-D-aspartate receptors. Endocrinology 1990; 127: 873-881.
8. Kawakami M, Uemura T, Hayashi R. Electrophysiology correlates of pulsatile gonadotropin release in rats. Neuroendocrinology 1982; 35: 63-67.
9. Bourguignon JP, Gérard A, Mathieu J, Simons J, Franchimont P. Pulsatile release of gonadotropin releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L- aspartate receptors. Endocrinology 1989; 125: 1090-1096.
10. Bourguignon JP, Gérard A, Alvarez Gonzalez ML, Purnelle G, Franchimont P. Endogenous glutamate involvement in pulsatile secretion of Gonadotropin-releasing hormone: evidence from glutamine effect and developmental changes. Endocrinology 1995; 136: 911-916.
11. Urbanski HF, Ojeda SR. Activation of Luteinizing-Hormone-Releasing Hormone release advances the onset of female puberty. Neuroendocrinology 1987; 46: 273-276.
12. Plant TM, Gay VL, Marshall GR, Arslan M. Puberty in monkeys is triggered by chemical stimulation. Proc Natl Acad Sci USA 1989; 86: 2506-2510.
13. Mitsushima D, Hei DL, Terasawa E. γ-aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA 1994; 91: 395-399.
14. Bourguignon JP, Gérard A, Alvarez Gonzalez ML, Franchimont P. Neuroendocrine mechanism of onset of puberty. Sequential reduction in activity of inhibitory and facilitatory N-methyl-D-aspartate receptors. J Clin Invest 1992; 90: 1736-1744.
15. Donoso AO, Lopez FJ, Negro-Vilar A. Cross-talk between excitatory and inhibitory amino acids in the regulation of luteinizing hormone-releasing hormone secretion. Endocrinology 1992; 131: 1559-1561.
16. Martinez de la Escalera G, Choi ALH, Weiner RI. Biphasic GABAergic regulation of GnRH secretion in GT1 cell lines. Neuroendocrinology 1994; 59: 420-425.
17. Hales TG, Sanderson MJ, Charles AC. GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1) neurons. Neuroendocrinology 1994; 59: 297-308.
18. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, Mishina M. Molecular diversity of the NMDA receptor channel. Nature 1992; 358: 36-41.
19. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992; 256: 1217-1221.
20. Schofield PR, Darlison MG, Fujita N, Burt DR, Stephenson FA, Rodriguez H, Rhee LM, Ramachandran J, Reale V, Glencorse TA, Seeburg PH & Barnard EA. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family. Nature 1987; 328: 221-227.
21. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. GABA A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J 1989; 8: 1665-1670.
22. Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE, Reis DJ. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature 1993; 363: 260-263.
23. Wagner RW. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994; 372: 333-335.
24. Bourguignon JP, Gérard A, Franchimont P. Direct activation of GnRH secretion through different receptors to neuroexcitatory amino acids. Neuroendocrinology 1989; 49: 402-408.
25. Boiziau C, Kurfurst R, Cazenave C, Roig V, Thuong NT, Toulmé JJ. Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism. Nucleic Acids Res 1991; 19: 1113-119.
26. Boiziau C, Thuong NT, Toulmé JJ. Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides. Proc Natl Acad Sci USA 1992; 89: 768-772.
27. Hélène C, Toulmé JJ. Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochem Biophys Acta 1990; 1049: 99-125.
28. Morris M, Lucion AB. Antisense oligonucleotides in the study of neuroendocrine systems. J Neuroendocr 1995; 7: 493-500.
29. Jirikowski GF, Sanna PP, Bloom FE. mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract. Proc Natl Acad Sci USA 1990; 87: 7400-7404.
30. Davis L, Banker GA, Steward O. Selective dendritic transport of RNA in hippocampal neurons in culture. Nature 1987; 330: 477-479.
31. Mahachoklertwattana P, Sanchez J, Kaplan SL, Grumbach MM. N-methyl-D-aspartate (NMDA) receptors mediate the release of Gonadotropin-releasing hormone (GnRH) by NMDA in a hypothalamic GnRH neuronal cell line (GT1-1). Endocrinology 1994; 134: 1023-1030.
32. i and Gonadotropin-releasing hormone secretion in immortalized hypothalamic GT1-7 neurons. Neuroendocrinology 1994; 59: 309-317.
33. Favit A, Wetsel WC, Negro-Vilar A. Differential expression of γ-aminobutyric acid receptors in immortalized luteinizing hormone-releasing hormone neurons. Endocrinology 1993; 133: 1983-1989.
34. Abbud R, Smith MS. Do GnRH neurons express the gene for the NMDA receptor? Brain Res 1995; 690: 117-120.
35. Eyigor O, Jennes L. Identification of glutamate receptor subtype mRNAs in Gonadotropin-releasing hormone neurons in rat brain. Endocrine 1996; 4: 133-139.
36. Gore AC, Wu TJ, Jacob J, Rosenberg J, Roberts JL. Gonadotropin-Releasing Hormone and NMDA receptor gene expression and colocalization change during puberty in female rats. J Neurosci 1996; 16: 5281-5289.
37. Ehlers MD, Tingley WG, Huganir RL. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science 1995; 269: 1734-1737.
38. Goldsmith PC, Thind KK, Perera AD & Plant TM. Glutamate-immunoreactive neurons and their Gonadotrophin-releasing hormone-neuronal interactions in the monkey hypothalamus. Endocrinology 1994; 134: 858-868.
39. Giovannucci DR, Stuenkel EL. An NMDA receptor on isolated secretory nerve endings. Brain Res 1995; 702: 246-250.
40. A receptor subunit mRNAs in cells of the preoptic area: colocalization with LHRH mRNA using dual-label in situ hybridization histochemistry. Endocrine J 1993; 1: 29-34.
41. Akema T, Chiba A, Kimura F. On the relationship between noradrenergic stimulatory and GABAergic inhibitory systems in the control of luteinizing hormone secretion in female rats. Neuroendocrinology 1990; 52: 566-572.
42. Moguilevsky JA, Carbone S, Szwarcfarb B, Rondina D. Sexual maturation modifies the GABAergic control of gonadotrophin secretion in female rats. Brain Res 1991; 563: 12-16.
43. Scott CJ, Clarke IJ. Inhibition of luteinizing hormone secretion in ovariectomized ewes during the breeding season by γ-aminobutyric acid (GABA) is mediated by GABA-A receptors, but not GABA-B receptors. Endocrinology 1993; 132: 1789-1796.
44. Kimura F, Sano A, Hiruma H, Funabashi T. Effects of γ-aminobutyric acid-A receptor antagonist, bicuculline, on the eletrical activity of luteinizing hormone-releasing hormone pulse generator in the ovariectomized rat. Neuroendocrinology 1993; 57: 605-614.
45. A-receptor-mediated inhibition at initiation of sexual maturation. J Neuroendocr 1997; 9: 193-199.
46. Herbison AE, Chapman C, Dyer RG. Role of medial preoptic GABA neurones in regulating luteinizing hormone secretion in the ovariectomized rat. Expl Brain Res 1991; 87: 345-352.
47. Jarry H, Leonhardt S, Wuttke W. Gamma aminobutyric acid neurones in the preoptic/anterior hypothalamic area synchronise the phasic activity of the gonadotropin-releasing hormone pulse generator in ovariectomized rats. Neuroendocrinology 1991; 53: 261-267.
48. Brown D, Herbison AE, Robinson JE, Marrs W, Leng G. Modelling the luteinizing hormone-releasing hormone pulse generator. Neuroscience 1994; 63: 869-879.
49. Thind KK, Goldsmith PC. Glutamate and gabaergic neurointeractions in the monkey hypothalamus: a quantitative immunomorphological study. Neuroendocrinology 1995; 61: 471-485.
50. Root AW, Reiter EO, Duckett GE, Sweetland ML. Effect of short-term castration and starvation upon hypothalamic content of luteinizing hormone-releasing hormone in adult male rats. Proc Soc Exp Biol Med 1975; 150: 602-607.
51. Krogsgaard-Larsen P. Gamma-aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem 1981; 24: 1377-1383.
52. 3H]TCP: a new tool with high affinity for the PCP receptor in rat brain. Brain Res 1983; 280: 194-197.
53. Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Watkins AE, Napias C, Greenlee DV. γ-aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites. Mol Pharmacol 1981; 19: 217-227.
54. Bourguignon JP, Gérard A, Franchimont P. Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty: II. Reduced potency of an inhibitory autofeedback. Endocrinology 1990; 127: 2884-2890.
55. Merriam GR, Wachter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol 1982; 243: pE310-E318.
56. Gitzen JF, Ramirez VD. PC Pulsar-Pulsar pulse analysis for the IBM-PC. Psychoneuroendocrinology 1987; 12: 3-6.