Action of free radical in podophyllic acid piperindyl hydrazone nitroxide radical on its antitumor activity and toxicity

Acta Pharmacologica Sinica

Volumn 20, Issue 6, 1999, Pages 571-576

  Jia, Zheng Ping ^a   Wang, Rui ^a   Xie, Jing Wen ^b   Xu, Li Ting ^b  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU GENERAL HOSPITAL   (China)

Author keywords

Antineoplastic agents; Cell cycle; Cultured tumor cells; Free radicals; Mitotic index; Nucleic acid synthesis inhibitors; Podophyllotoxin; Toxicity tests

Indexed keywords

FORMAZAN; PODOPHYLLIC ACID PIPERIDINYL HYDRAZONE; PODOPHYLLIC ACID PIPERIDINYL HYDRAZONE NITROXIDE DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; THYMIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CYTOTOXICITY; DNA SYNTHESIS; DOSE RESPONSE; IMMUNE FUNCTION TEST; LEWIS CARCINOMA; MITOSIS INDEX; MOUSE; NONHUMAN;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DNA, NEOPLASM; LEUKEMIA L1210; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MITOTIC INDEX; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PODOPHYLLOTOXIN; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0033012947     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Zhang JZ, Zhao BL, Zhang QG, editors. Basic theory and application of spin labelling ESR spectrum. 1st ed. Beijing : Science Press; 1987. p 34-195.
2. Anastassopoulou JD, Rakintzis NT. Reaction of radical with 2, 2, 6, 6,-tetramethyl-4-piperidinyl-1-oxy (TEMPOL) in aqueous solution. Z Phys Chem Neue Folge 1984; 141: S53-S58.
3. Wu YJ, Li WG, Zhang ZM, Tian X. Antioxidative activity of 4-oxy- and 4-hydroxy-nitroxides in tissues and erythrocytes from rats. Acta Pharmacol Sin 1997; 18: 150-4.
4. Emanuel NM, Konovalova, Djachkovskaya RF. Toxicity antitumor activity, and pharmacokinetics of spin-labeled thioTEPA analogs. Cancer Treat Rep 1976; 60: 1605-9.
5. Sosnovsky G, Rao NUM, Li SW. In the search for new anticancer drugs. 19. A predictive design for N, N: N′, N′: N′, N′-tri-1, 2-ethanediylphosphoric triamide (TEPA) analogues. J Med Chem 1986; 29: 2225-30.
6. Chen YZ, Wang YG, Li JX, Tian X, Jia ZP, Zhang PY. Anticancer drugs synthesis and biological evaluation of spin labeled derivative of podophyllotoxin. Life Sci 1989; 45: 2569-75.
7. Jia ZP, Zhang PY, Liang ZD, Wang YG, Chen YZ, Tian X, et al. Antitumor activity of 4-[4″-(2″, 2″, 6″, 6″-tetramethyl-1-piperindyloxy ) amino]-4′-demethyl-epipodophyllotoxin in vitro. Acta Pharmacol Sin 1990 11: 519-53.
8. Tian X, Wang YG, Yang MG, Chen YZ. Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin. Life Sci 1997; 60: 511-7.
9. Chen YZ, Zhang CJ. Study on spin labeling analysis-synthesis and ESR determination of spin-labeled antitumor podophyllotoxin derivatives. Sci Bull 1982; 13: 1367-9.
10. Wang DW, Zhang PY, Liang ZD, Meng FM. Podophyllic acid ethylhydrazide and podophyllic acid piperindyl hydrazone nitroxide radical on the transplanted tumors in mice. J Lanzhou Med Coll 1981; 10 (4) : 19-21.
11. Wang JZ, Zhang PY, Liang ZD. Effects of podophyllic acid piperindyl hydrazone nitroxide radical (GP-1) and VP-16 on the proliferation, mitotic index and DNA synthesis of some cancer cells in vitro. Chin Pharmacol Bull 1989; 5: 40-3.
12. Wang JZ, Mao XJ, Zhang PY, Liang ZD, Tian X. Effects of podophyllic acid piperindyl hydrazone nitroxide radical and etoposide on nucleic acids and protein metabolism of leukmia L7712 cells in vitro. Acta Pharmacol Sin 1989; 10: 377-80.
13. Chen MZ, Wei W, Zhang H, Liang JS. Methods of pharmacological experiment of immune drugs. In; Xu SY, Bian RL, Chen X, editors. Methodology of Pharmacological Experiment. 2nd ed. Beijing; People's Health Publishing Corp; 1991. p 1208-45.
14. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival; modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-7.