Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs

Clinical and Experimental Allergy, Supplement

Volumn 29, Issue 2, 1999, Pages 48-52

  Schuiling, M ^a   Zuidhof, A B ^a   Zaagsma, J ^a   Meurs, H ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Airway hyperresponsiveness; Airway inflammation; Allergic asthma; Guinea pigs; Histamine; NK1 receptor; NK2 receptor; SR 140333; SR 48968; Tachykinins

Indexed keywords

ALLERGEN; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NOLPITANTIUM; SAREDUTANT; TACHYKININ; BENZAMIDE DERIVATIVE; OVALBUMIN; PIPERIDINE DERIVATIVE; QUINUCLIDINE DERIVATIVE;

AIRWAY OBSTRUCTION; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CHRONIC INFLAMMATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHILIA; GUINEA PIG; LUNG LAVAGE; LYMPHOCYTE; NEUTROPHIL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; ARTICLE; ASTHMA; BRONCHITIS; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; EOSINOPHIL; IMMUNOLOGY; INHALATION TEST; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY;

ALLERGENS; ANIMALS; ASTHMA; BENZAMIDES; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHITIS; CHEMOTAXIS, LEUKOCYTE; EOSINOPHILS; GUINEA PIGS; LYMPHOCYTES; NEUTROPHILS; OVALBUMIN; PIPERIDINES; QUINUCLIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2;

EID: 0033012905     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (41)

1. Barnes PJ, Baraniuk JN, Belvisi MG. Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis 1991; 144:1391-9.
2. Advenier C, Lagente V, Boichot E. The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. Eur Respir J 1997; 10:1892-906.
3. Bertrand C, Geppetti P. Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic airway disease. Trends Pharmacol Sci 1996; 17:255-9.
4. Frossard N, Advenier C. Tachykinin receptors and the airways. Life Sci 1991; 49:1941-53.
5. Qian Y, Emonds Alt X, Advenier C. Effects of capsaicin, (+/-) -CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs. Pulm Pharmacol 1993; 6:63-7.
6. Tousignant C, Chan CC, Guevremont D et al. NK2 receptors mediate plasma extravasation in guinea-pig lower airways. Br J Pharmacol 1993; 108:383-6.
7. Lilly CM, Hall AE, Rodger IW et al. Substance P-induced histamine release in trachecally perfused guinea pig lungs. J Appl Physiol 1995; 78:1234-41.
8. Kudlacz EM, Knippenberg RW. In vitro and in vivo effects of tachykinins on immune cell function in guinea pig airways. J Neuroimmunol 1994; 50:119-25.
9. Nieber K, Baumgarten CR, Rathsack R et al. Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. J Allergy Clin Immunol 1992; 90:646-52.
10. Tomaki M, Ichinose M, Miura M et al. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am J Respir Crit Care Med 1995; 151:613-7.
11. Ollerenshaw SL, Jarvis D, Sullivan CE, Woolcock AJ. Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur Respir J 1991; 4:673-82.
12. Adcock IM, Peters M, Gelder C et al. Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. J Mol Endocrinol 1993; 11:1-7.
13. 2)-receptor gene expression in inflammatory airway diseases. Am J Physiol 1995; 269:1309-17.
14. Joos GR, Pauwels R, Van der Straeten M. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 1987; 42:779-83.
15. Cheung D, Timmers MC, Zwinderman AH et al. Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. Am Rev Respir Dis 1993; 148:1467-73.
16. Cheung DH, Van der Veen H, Den Hartigh J, Dijkman JH, Sterk PJ. Effects of inhaled substance P on airway responsiveness to methacholine in asthmatic subjects in vivo. J Appl Physiol 1994; 77:1325-32.
17. Santing RE, Meurs H, van der Mark TW et al. A novel method to assess airway function parameters in chronically instrumented, unrestrained guinea-pigs. Pulm Pharmacol 1992; 5:265-72.
18. Santing RE, Olymulder CG, Zaagsma J, Meurs H. Relationships among allergen-induced early and late phase airway obstructions, bronchial hyperreactivity, and inflammation in conscious, unrestrained guinea pigs. J Allergy Clin Immunol 1994; 93:1021-30.
19. Van Amsterdam RG, Brouwer F, Zaagsma J. Analysis of the beta-adrenoceptor mediated inhibition of IgG1 and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction. Agents Actions 1989; 26:48-51.
20. Ingenito EP, Pliss LB, Martins MA, Ingram RH Jr. Effects of capsaicin on mechanical, cellular, and mediator responses to antigen in sensitized guinea pigs. Am Rev Respir Dis 1991; 143:572-7.
21. Lai YL. Endogenous tachykinins in antigen-induced acute bronchial responses of guinea pigs. Exp Lung Res 1991; 17:1047-60.
22. Fischer A, McGregor GP, Saria A, Philippin B, Kummer W. Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J Clin Invest 1996; 98:2284-91.
23. Nadel JA. Neutral endopeptidase modulates neurogenic inflammation. Eur Respir J 1991; 4:745-54.
24. Gleich GJ, Flavahan NA, Fujisawa T, Vanhoutte PM. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J Allergy Clin Immunol 1988; 81:776-81.
25. Wardlaw AJ, Dunette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988; 137:62-9.
26. Corrigan CJ, Kay AB. Asthma. Role of T-lymphocytes and lymphokines. Br Med Bull 1992; 48:72-84.
27. 4 production between eosinophils and neutrophils. Int Arch Allergy Appl Immunol 1989; 90:20-3.
28. Melzer S, Goldberg B, Lad P, Easton J. Superoxide generation and its modulation by adenosine in the neutrophils of subjects with asthma. J Allergy Clin Immunol 1989; 83:960-6.
29. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Repir Crit Care Med 1995; 151:1894-9.
30. Schuiling M, Meurs H, Zuidhof AB, Zaagsma J, Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs. Am J Respir Crit Care Med 1998; 158:1442-9.
31. Sadeghi Hashjin G, Folkerts G, Henricks PA et al. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med 1996; 153:1697-701.
32. Brunelleschi S, Vanni L, Ledda F et al. Tachykinins activate guinea-pig alveolar macrophages. Involvement of NK2 and NK1 receptors. Br J Pharmacol 1990; 100:417-20.
33. Boichot E, Lagente V, Paubert Braquet M, Frossard N. Inhaled substance P induces activation of alveolar macrophages and increases airway responses in the guinea-pig. Neuropeptides 1993; 25:307-13.
34. 2 receptor antagonist, SR 48968, of antigen-induced airway hyperresponsiveness in sensitized guinea-pigs. Br J Pharmacol 1995; 114:259-61.
35. Santing RE, Pasman Y, Olymulder CG et al. Contribution of a cholinergic reflex mechanism to allergen-induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea-pigs. Br Pharmacol 1995; 114:414-8.
36. Belvisi MG, Patacchini R, Barnes PJ, Maggi CA. Facilitatory effects of selective agonists for tachykinin receptors on cholinegic neurotransmission: evidence for species differences. Br J Pharmacol 1994; 111:103-10.
37. Santing RH, Hoekstra Y, Pasman Y, Zaagsma J, Meurs H. The importance of eosinophil activation for the development of allergen-induced bronchial hyperreactivity in conscious, unrestrained guinea pigs. Clin Exp Allergy 1994; 24:1157-63.
38. 1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea. Am J Physiol 1995; 268:L263-9.
39. Kroegel C, Giembycz MA, Barnes PJ. Characterization of eosinophil cell activation by peptides. Differential effects of substance P, melittin, and FMET-Leu-Phe. J Immunol 1990; 145:2581-7.
40. Hogg JC. Bronchial mucosal permeability and its relationship to airways hyperreactivity. Eur J Respir Dis Suppl 1982; 122:17-22.
41. 1 receptor antagonist. Br J Pharmacol 1992; 105:261-2.