Specificity and function of immunogenic peptides from the 35-kilodalton protein of Mycobacterium leprae

Infection and Immunity

Volumn 67, Issue 3, 1999, Pages 1501-1504

  Wilkinson, Robert John ^a,b,c   Wilkinson, Katalin Andrea ^a   Jurcevic, Stipo ^a   Hills, Adrian ^a   Sinha, Sudhir ^d   Sengupta, Utpal ^e   Lockwood, Diana N J ^f   Katoch, Kiran ^e   Altman, Daniel ^a   Ivanyi, Juraj ^a,g  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NORTHWICK PARK HOSPITAL   (United Kingdom)

^c NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^d CENTRAL DRUG RESEARCH INSTITUTE   (India)

^e NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^g KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CYTOKINE; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; SYNTHETIC PEPTIDE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROSS ALLERGY; CROSS REACTION; HUMAN; IMMUNOGENICITY; LEPROSY; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; MYCOBACTERIUM AVIUM; MYCOBACTERIUM LEPRAE; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; T LYMPHOCYTE;

EID: 0033012619     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.3.1501-1504.1999     Document Type: Article

References (25)

1. Altmann, D. M., D. C. Douek, A. J. Frater, C. Hetherington, H. Inoko, and J. I. Elliott. 1995. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J. Exp. Med. 181:867-875.
2. Booth, R. J., D. L. Williams, K. D. Moudgil, L. C. Noonan, P. M. Grandison, J. J. McKee, R. L. Prestidge, and J. D. Watson. 1993. Homologs of Mycobacterium leprae 18-kilodalton and Mycobacterium tuberculosis 19-kilodalton antigens in other mycobacteria. Infect. Immun. 61:1509-1515.
3. Chua-Intra, B., S. Peerapakorn, N. Davey, S. Jurcevic, M. Busson, H. M. Vordermeier, C. Pirayavaraporn, and J. Ivanyi. 1998. T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts. Infect. Immun. 66:4903-4909.
4. Gong, J.-H., M. Zhang, R. L. Modlin, P. S. Linsley, D. Iyer, Y. Lin, and P. Barnes. 1996. Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression. Infect. Immun. 64:913-918.
5. Gorga, J. C., J. Foran, S. J. Burakoff, and J. L. Strominger. 1984. Use of the HLA-DR antigens incorporated into liposomes to generate HLA-DR specific cytotoxic T lymphocytes. Methods Enzymol. 108:607-613.
6. Gorga, J. C., V. Horejsi, D. R. Johnson, R. Raghupathy, and J. L. Strominger. 1987. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J. Biol. Chem. 262: 16087-16094.
7. Hill, A. V. S. 1998. Immunogenetics of human infectious diseases. Annu. Rev. Immunol. 16:593-617.
8. Hunter, S. W., B. Rivoire, V. Mehra, B. R. Bloom, and P. J. Brennan. 1990. The major native proteins of the leprosy bacillus. J. Biol. Chem. 265:14065-14068.
9. Ivanyi, J., J. A. Morris, and M. Keen. 1985. Studies with monoclonal antibodies to mycobacteria, p. 59-90. In A. J. L. Macario (ed.), Monoclonal antibodies against bacteria, vol. 1. Academic Press, New York, N.Y.
10. Janson, A. A., P. R. Klatser, R. van der Zee, Y. E. Cornelisse, R. R. de Vries, J. E. Thole, and T. H. Ottenhoff. 1991. A systematic molecular analysis of the T cell-stimulating antigens from Mycobacterium leprae with T cell clones of leprosy patients. Identification of a novel M. leprae HSP 70 fragment by M. leprae-specific T cells. J. Immunol. 147:3530-3537.
11. Jurcevic, S., A. Hills, G. Pasvol, R. N. Davidson, J. Ivanyi, and R. J. Wilkinson. 1996. T cell responses to a mixture of Mycobacterium tuberculosis peptides with complementary HLA-DR binding profiles. Clin. Exp. Immunol. 105:416-421.
12. Kim, J., A. Sette, S. Rodda, S. Southwood, P. A. Sieling, V. Mehra, J. D. Ohmen, J. Oliveros, E. Appell, Y. Higashmoto, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1997. Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue. J. Immunol. 159:335-343.
13. Misra, N., A. Murtaza, B. Walker, N. P. Narayanan, R. S. Misra, V. Ramesh, S. Singh, M. J. Colston, and I. Nath. 1995. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 86:97-103.
14. Misra, N., M. Selvakumar, S. Singh, M. Bharadwaj, V. Ramesh, R. S. Misra, and I. Nath. 1995. Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. Immunol. Lett. 48:123-128.
15. Mohagheghpour, N., M. W. Munn, R. H. Gelber, and E. G. Engleman. 1990. Identification of an immunostimulating protein from Mycobacterium leprae. Infect. Immun. 58:703-710.
16. Poennighaus, J. M., P. E. M. Fine, J. A. C. Sterne, R. J. Wilson, E. Msosa, P. J. K. Gruer, P. A. Jenkins, S. B. Lucas, N. G. Liomba, and L. Bliss. 1992. Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi. Lancet 339:636-639.
17. Roche, P. W., W. J. Britton, S. S. Failbus, H. Ludwig, W. J. Theuvenet, and W. B. Adiga. 1990. Heterogeneity of serological responses in paucibacillary leprosy; differential responses to protein and carbohydrate antigens and correlation with clinical parameters. Int. J. Lepr. 58:319-327.
18. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J. Immunol. 150:5501-5510.
19. Sinha, S., U. Sengupta, G. Ramu, and J. Ivanyi. 1985. Serological survey of leprosy and control subjects by a monoclonal antibody-based immunoassay. Int. J. Lepr. Other Mycobact. Dis. 53:33-38.
20. Thole, J. E., B. Wieles, J. E. Clark-Curtiss, T. H. Ottenhoff, and T. F. de Wit. 1995. Immunological and functional characterization of Mycobacterium leprae protein antigens: an overview. Mol. Microbiol. 18:791-800.
21. Triccas, J. A., P. A. Roche, N. Winter, C. G. Feng, R. Butlin, and W. J. Britton. 1996. A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae. Infect. Immun. 64:5171-5177.
22. Triccas, J. A., N. Winter, P. W. Roche, A. Gilpin, K. E. Kendrick, and W. J. Britton. 1998. Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobaclerium leprae 35-kilodalton protein. Infect. Immun. 66:2684-2690.
23. Wilkinson, R. J., H. M. Vordermeier, K. A. Wilkinson, A. Sjölund, C. Moreno, G. Pasvol, and J. Ivanyi. 1998. Peptide specific response to M. tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy. J. Infect. Dis. 178:760-768.
24. Wilkinson, R. J., K. A. Wilkinson, K. A. L. De Smet, K. Haslov, G. Pasvol, M. Singh, I. Svarcova, and J. Ivanyi. 1998 Human T and B cell reactivity to the 16 kDa alpha crystallin protein of Mycobacterium tuberculosis. Scand. J. Immunol. 48:403-409.
25. Winter, N., J. A. Triccas, B. Rivoire, M. C. V. Pessolani, K. Eiglmeier, E. M. Lim, S. W. Hunter, P. J. Brennan, and W. J. Britton. 1995. Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae. Mol. Microbiol. 16:865-876.