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Volumn 126, Issue 5, 1999, Pages 1147-1152

Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase

Author keywords

Human neutrophil elastase; Lung injury; Synthetic elastase inhibitor

Indexed keywords

ELASTASE INHIBITOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; PROTEINASE; TEI 8362; UNCLASSIFIED DRUG;

EID: 0033012580     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702425     Document Type: Article
Times cited : (15)

References (27)
  • 1
    • 0025156860 scopus 로고
    • A modified bronchoalveolar lavage procedure that allows measurement of lung epithelial lining fluid volume
    • BARRY, T.P., STEVEN, I., CASSANDRAY, M., LYNN, D.G. & ALLEN, B.C. (1990). A modified bronchoalveolar lavage procedure that allows measurement of lung epithelial lining fluid volume. Am. Rev, Respir. Dis., 141, 314-320.
    • (1990) Am. Rev, Respir. Dis. , vol.141 , pp. 314-320
    • Barry, T.P.1    Steven, I.2    Cassandray, M.3    Lynn, D.G.4    Allen, B.C.5
  • 2
    • 0029961891 scopus 로고    scopus 로고
    • Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion
    • CAI, T.-Q. & WRIGHT, S.D. (1996). Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion. J. Exp. Med., 184, 1213-1223.
    • (1996) J. Exp. Med. , vol.184 , pp. 1213-1223
    • Cai, T.-Q.1    Wright, S.D.2
  • 3
    • 0028365927 scopus 로고
    • Pharmacology of N-[4-(4-morpholinyl-carbonyl) benzoyl]-l-valyl-N-[3,3,4,4,4-pentafluoro-i-(1-methy-lethyl)-2-oxobutyl]-l- prolinamide (MDL-101, 146): A potent orally active inhibitor of human neutrophil elastase
    • DURHAM, S.L., HARE, C.M., ANGELASTRO, M.R., BURKHART, J.P., KOEHL, J.R., MARQUART, A.L., MEHDI, S., PEET, N.P. & JANUSZ, M.J. (1994). Pharmacology of N-[4-(4-morpholinyl-carbonyl) benzoyl]-L-valyl-N-[3,3,4,4,4-pentafluoro-I-(1-methy-lethyl)-2-oxobutyl]-L- prolinamide (MDL-101, 146): A potent orally active inhibitor of human neutrophil elastase. J. Pharmacol. Exp. Ther., 270, 185-191.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 185-191
    • Durham, S.L.1    Hare, C.M.2    Angelastro, M.R.3    Burkhart, J.P.4    Koehl, J.R.5    Marquart, A.L.6    Mehdi, S.7    Peet, N.P.8    Janusz, M.J.9
  • 4
    • 0025343238 scopus 로고
    • A comparison of α-1-proteinase inhibitor methoxysuccinyl-ala-ala-pro-val-chloromethylketone and specific β-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung haemorrhage in the hamster
    • FLETCHER, D.S., OSINGA, D.G., HAND, K.M., DELLEA, S.P., ASHE, B.M., MUMFORD, R.A., DAVIES, P., HAGMANN, W., FINKE, P.E., DOHERTY, J.B. & BONNEY, R.J. (1990). A comparison of α-1-proteinase inhibitor methoxysuccinyl-ala-ala-pro-val-chloromethylketone and specific β-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung haemorrhage in the hamster. Am. Rev. Respir. Dis., 141, 672-677.
    • (1990) Am. Rev. Respir. Dis. , vol.141 , pp. 672-677
    • Fletcher, D.S.1    Osinga, D.G.2    Hand, K.M.3    Dellea, S.P.4    Ashe, B.M.5    Mumford, R.A.6    Davies, P.7    Hagmann, W.8    Finke, P.E.9    Doherty, J.B.10    Bonney, R.J.11
  • 5
    • 0022485439 scopus 로고
    • Lysosomal enzymes from polymorphonudear leukocytes and proteinase inhibitors in cystic fibrosis
    • GOLDSTEIN, W. & DÖRING, G. (1986). Lysosomal enzymes from polymorphonudear leukocytes and proteinase inhibitors in cystic fibrosis. Am. Rev. Respir. Dis., 134, 49-56.
    • (1986) Am. Rev. Respir. Dis. , vol.134 , pp. 49-56
    • Goldstein, W.1    Döring, G.2
  • 9
    • 0025212549 scopus 로고
    • Recombinant human secretory leukocyte-protease inhibitor: In vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster
    • LUCEY, E.C., STONE, P.J., CICCOLELLA, D.E., BREUER, R., CHRISTENSEN, T.G., THOMPSON, R.C. & SNIDER, G.L. (1990). Recombinant human secretory leukocyte-protease inhibitor: In vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster. J. Lab. Clin. Med., 115, 224-232.
    • (1990) J. Lab. Clin. Med. , vol.115 , pp. 224-232
    • Lucey, E.C.1    Stone, P.J.2    Ciccolella, D.E.3    Breuer, R.4    Christensen, T.G.5    Thompson, R.C.6    Snider, G.L.7
  • 10
    • 0018566723 scopus 로고
    • Sensitive substrates for human leukocyte and pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assay for serine proteases
    • MARIO, J.C., KIICHIRO, N., MORRIS, Z. & JAMES, C.R. (1979). Sensitive substrates for human leukocyte and pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assay for serine proteases. Anal. Biochem., 99, 53-64.
    • (1979) Anal. Biochem. , vol.99 , pp. 53-64
    • Mario, J.C.1    Kiichiro, N.2    Morris, Z.3    James, C.R.4
  • 11
    • 0014487526 scopus 로고
    • Evaluation of the internationally standardized method for haemoglobinometry
    • MATSUBARA, T. & SHIBATA, S. (1969). Evaluation of the internationally standardized method for haemoglobinometry. Clin. Chim. Acta, 23, 427-430.
    • (1969) Clin. Chim. Acta , vol.23 , pp. 427-430
    • Matsubara, T.1    Shibata, S.2
  • 12
    • 0026059903 scopus 로고
    • Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory disease
    • MIKAMI, M. (1991). Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory disease. Jpn. J. Thora. Dis., 29, 72-83.
    • (1991) Jpn. J. Thora. Dis. , vol.29 , pp. 72-83
    • Mikami, M.1
  • 13
    • 0030802997 scopus 로고    scopus 로고
    • Potency of truncated secretory leukoprotease inhibitor assessed in acute lung injury models in hamsters
    • MITSUHASHI, H., ASANO, S., NONAKA, T., MASUDA, K. & KIYOKI, M. (1997). Potency of truncated secretory leukoprotease inhibitor assessed in acute lung injury models in hamsters. J. Pharmacol. Exp. Ther., 282, 1005-1010.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 1005-1010
    • Mitsuhashi, H.1    Asano, S.2    Nonaka, T.3    Masuda, K.4    Kiyoki, M.5
  • 14
    • 0026681802 scopus 로고
    • Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
    • NAKAMURA, H., YOSHIMURA, K., MCELVANEY, N.G. & CRYSTAL, R.G. (1992). Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J. Clin. Invest., 89, 1478-1484.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1478-1484
    • Nakamura, H.1    Yoshimura, K.2    McElvaney, N.G.3    Crystal, R.G.4
  • 15
    • 0026032732 scopus 로고
    • Inhibition of chymotrypsin and pancreatic elastase by 4H-3, 1-benzoxazin-4-ones
    • NEUMANN, U., STURZEBECHER, J., LEISTNER, S. & VIEWEG, H. (1991). Inhibition of chymotrypsin and pancreatic elastase by 4H-3, 1-benzoxazin-4-ones. J. Enzyme Inhibition, 4, 227-232.
    • (1991) J. Enzyme Inhibition , vol.4 , pp. 227-232
    • Neumann, U.1    Sturzebecher, J.2    Leistner, S.3    Vieweg, H.4
  • 16
    • 0026451068 scopus 로고
    • Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease
    • PICCIONI, P.D., KRAMPS, J.A., RUDOLPHUS, A., BULGHERONI, A. & LUISETTI, M. (1992). Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Chest, 102, 1470-1476.
    • (1992) Chest , vol.102 , pp. 1470-1476
    • Piccioni, P.D.1    Kramps, J.A.2    Rudolphus, A.3    Bulgheroni, A.4    Luisetti, M.5
  • 17
    • 0026599949 scopus 로고
    • Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200, 355
    • lung Cell. Mol. Physiol. 6
    • SCHUSTER, A., UEKI, I. & NADEL, J.A. (1992). Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200, 355. Am. J. Physiol., 262 (lung Cell. Mol. Physiol. 6), L86-L91.
    • (1992) Am. J. Physiol. , vol.262
    • Schuster, A.1    Ueki, I.2    Nadel, J.A.3
  • 19
    • 0023601033 scopus 로고
    • Bronchiectasis-new therapeutic approaches based on pathogenesis
    • STOCKLEY, R.A. (1987). Bronchiectasis-New therapeutic approaches based on pathogenesis. Clinics in Chest Medicine, 8, 481-493.
    • (1987) Clinics in Chest Medicine , vol.8 , pp. 481-493
    • Stockley, R.A.1
  • 20
    • 0029947548 scopus 로고    scopus 로고
    • Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leukoprotease inhibitor
    • SUZUKI, T., WANG, W., LIN, J.-T., SHIRATO, K., MITSUHASHI, H. & INOUE, H. (1996). Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leukoprotease inhibitor. Am. J. Respir. Crit. Care Med., 153, 1405-1411.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , pp. 1405-1411
    • Suzuki, T.1    Wang, W.2    Lin, J.-T.3    Shirato, K.4    Mitsuhashi, H.5    Inoue, H.6
  • 21
    • 0026639946 scopus 로고
    • Role of neutrophil elastase in allergen-induced lysozyme secretion in the dog trachea
    • TABACHNIK, E., SCHUSTER, A., GOLD, W.M. & NADEL, J.A. (1992). Role of neutrophil elastase in allergen-induced lysozyme secretion in the dog trachea. J. Appl. Physiol., 73, 695-700.
    • (1992) J. Appl. Physiol. , vol.73 , pp. 695-700
    • Tabachnik, E.1    Schuster, A.2    Gold, W.M.3    Nadel, J.A.4
  • 22
    • 0029868471 scopus 로고    scopus 로고
    • Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor
    • THOMPSON, K. & RABINOVITCH, M. (1996). Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor. J. Cell. Physiol., 166, 495-505.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 495-505
    • Thompson, K.1    Rabinovitch, M.2
  • 23
    • 0025374923 scopus 로고
    • Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch
    • TOSI, M., ZAKEM, H. & BERGER, M. (1990). Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch. J. Clin. Invest., 86, 300-308.
    • (1990) J. Clin. Invest. , vol.86 , pp. 300-308
    • Tosi, M.1    Zakem, H.2    Berger, M.3
  • 24
    • 0017350112 scopus 로고
    • Proteases from purulent sputum. Purification and properties of the elastase and chymotrypsin-like enzymes
    • TWUMASI, D.Y. & LEINER, I.E. (1977). Proteases from purulent sputum. Purification and properties of the elastase and chymotrypsin-like enzymes. J. Biol. Chem., 252, 1917-1926.
    • (1977) J. Biol. Chem. , vol.252 , pp. 1917-1926
    • Twumasi, D.Y.1    Leiner, I.E.2
  • 25
    • 0027428786 scopus 로고
    • 5-methyl-4H-3, 1-benzoxazin-4-one derivative: Specific inhibitor of human leukocyte elastase
    • UEJIMA, Y., KOKUBO, M., OSHIDA, J., KAWABATA, H., KATO, Y. & FIJII, K. (1993). 5-methyl-4H-3, 1-benzoxazin-4-one derivative: Specific inhibitor of human leukocyte elastase. J. Pharmacol. Exp. Ther., 265, 516-523.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 516-523
    • Uejima, Y.1    Kokubo, M.2    Oshida, J.3    Kawabata, H.4    Kato, Y.5    Fijii, K.6
  • 27
    • 0026404402 scopus 로고
    • Biochemistry and pharmacology for ICI 200,880, a synthetic peptide inhibitor
    • WILLIAMS, J.C., STEIN, R.L., GILES, R.A. & KRELL, K.O. (1991). Biochemistry and pharmacology for ICI 200,880, a synthetic peptide inhibitor. Ann. N.Y. Acad. Sci., 624, 230-243.
    • (1991) Ann. N.y. Acad. Sci. , vol.624 , pp. 230-243
    • Williams, J.C.1    Stein, R.L.2    Giles, R.A.3    Krell, K.O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.