High-density Escherichia coli cultures for continuous L(-)-carnitine production

Applied Microbiology and Biotechnology

Volumn 51, Issue 6, 1999, Pages 760-764

  Obon J M ^a   Maiquez, J R ^a   Canovas M ^a   Kleber, H P ^a,b   Iborra, J L ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; FUMARIC ACID; PEPTONE; POLYURETHAN;

ARTICLE; BACTERIUM CULTURE; BIOTRANSFORMATION; CELL DENSITY; CHEMICAL ANALYSIS; CHEMICAL REACTION; DATA ANALYSIS; ENANTIOMER; ENZYME ACTIVITY; ESCHERICHIA COLI; FERMENTATION; VIRUS CULTURE;

ACYLTRANSFERASES; ANAEROBIOSIS; BETAINE; BIOREACTORS; CARNITINE; CULTURE MEDIA; ENZYME INDUCTION; ESCHERICHIA COLI; HYDRO-LYASES; INDUSTRIAL MICROBIOLOGY;

EID: 0033012513     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002530051459     Document Type: Article

References (28)

1. Aeschlimann A, Stockar U von (1991) Continuous production of lactic acid from whey permeate by Lactobacillus helveticus in a cell-recycle reactor. Enzyme Microb Technol 13: 811-816
2. Bibal B, Vayssier Y, Goma G, Pareilleux A (1991) High-concentration cultivation of Lactococcus cremoris in a cell-recycle reactor. Biotechnol Bioeng 37: 746-754
3. Bremen RH, Vienna EK (1990) Carnitine: biochemical, analytical, experimental and clinical aspects. J Clin Chem Clin Biochem 28: 289-363
4. Cavazza C (1981) D-Camphorate of L-carnitinamide and D-camphorate of D-carnitinamide. BE patent 877609 A1
5. Chang HN, Yoo I-K, Kim BS (1994) High density cell culture by membrane-based cell recycle. Biotechnol Adv 12: 467-487
6. Defrise D, Gekas V (1988) Microfiltration membranes and the problem of microbial adhesion: a literature survey. Process Biochem 8: 105-118
7. Gatenholm P, Paterson S, Fane AG, Fell JD (1988) Performance of synthetic membranes during cell harvesting of E. coli. Process Biochem 6: 79-81
8. Hamari Yakuhin Kogyo Co Ltd (1984) Optical resolution of carnitine. JP patent 59,231,048
9. Hoeks FWJMM, Kulla H, Meyer H-P (1992) Continuous cell-recycle process for L-carnitine production: performance, engineering and downstream processing aspects compared with discontinuous processes. J Biotechnol 22: 117-128
10. Hoeks FWJMM, Mühle J, Böhlen L, Psenicka I (1996) Process integration aspects for the production of fine biochemicals illustrated with the biotransformation of y-butyrobetaine into L-carnitine. Chem Eng J Biochem Eng J 61: 53-61
11. Jung H, Jung K, Kleber H-P (1989) Purification and properties of carnitine dehydratase from Escherichia coli - a new enzyme of carnitine metabolization. Biochim Biophys Acta 1003: 270-276
12. Jung H, Jung K, Kleber H-P (1993) Synthesis of L-carnitine by microorganisms and isolated enzymes. Adv Biochem Eng Biotechnol 50: 21-44
13. Kleber H-P (1997) Bacterial carnitine metabolism. FEMS Microbiol Lett 147: 1-9
14. Kröger A (1978) Fumarate as terminal acceptor of phosphorylative electron transport. Biochim Biophys Acta 505: 129-145
15. Kulla H (1991) Enzymatic hydroxylations in industrial application. Chimia 45: 81-85
16. Lee CW, Gu MB, Chang HN (1989) High-density culture of Escherichia coli carrying recombinant plasmid in a membrane cell recycle fermenter. Enzyme Microb Technol 11: 49-54
17. Lee YL, Chang HN (1990) High cell density culture of a recombinant Escherichia coli producing penicillin acylase in a membrane cell recycle fermentor. Biotechnol Bioeng 36: 330-337
18. Lee SY (1996) High cell-density culture of Escherichia coli. Trends Biotechnol 14: 98-105
19. Marzo A, Monti N, Ripamonti M, Martelli EA (1988) Application of high-performance liquid chromatography to the analysis of propionyl-L-carnitine by a stereospecific enzyme assay. J Chromatogr 459: 63-69
20. Obón JM, Maiquez JR, Cánovas M, Kleber H-P, Iborra JL (1997) L(-)-Carnitine production with immobilized Escherichia coli cells in continuous reactors. Enzyme Microb Technol 21: 531-536
21. Pons R, De Vivo DC (1995) Primary and secondary carnitine deficiency syndromes. J Child Neurol 10: 8-24
22. Qureshi N, Cheryan M (1989) Production of 2,3-butanediol in a membrane recycle reactor. Process Biochem 10: 172-175
23. Rebouche CJ, Paulson DJ (1986) Carnitine metabolism and fuction in human. Annu Rev Nutr 6: 41-66
24. Roth S, Jung K, Jung H, Hommel RK, Kleber H-P (1994) Crotonobetaine reductase from Escherichia coli - a new inducible enzyme of anaerobic metabolization of L-carnitine. Antonie van Leeuwenhoek 65: 63-69
25. Seim H, Kleber H-P (1988) Synthesis of L(-)-carnitine by hydration of crotonobetaine by enterobacteria. Appl Microbiol Biotechnol 27: 538-544
26. Seim H, Loester H, Claus R, Kleber H-P, Strack E (1985) L-Carnitine and its derivatives. DD patent 221,905
27. Van Verseveld HW, Arbige M, Chesbro WR (1984) Continuous culture of bacteria with biomass retention. Trends Biotechnol 2: 8-12
28. Wieland OH, Deufel T, Paetzke-Brunner J (1985) Free and esterified carnitine. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol 8, 3rd edn. VCH, Weinheim, pp 481-488