Blockade of 5-HT(1A) receptors compensates loss of hippocampal cholinergic neurotransmission involved in working memory of rats

Brain Research

Volumn 736, Issue 1-2, 1996, Pages 180-188

  Ohno, Masuo ^a   Watanabe, Shigenori ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

( ) 3 (2 carboxypiperazin 4 yl)propyl 1 phosphonic acid; 5 HT(1A) receptor; acetylcholine; hippocampus; NAN 190; NMDA receptor; scopolamine; working memory

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SCOPOLAMINE; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; 1 (2 METHOXYPHENYL) 4 (4 (2 PHTHALIMIDO)BUTYL)PIPERAZINE; 1-(2-METHOXYPHENYL)-4-(4-(2-PHTHALIMIDO)BUTYL)PIPERAZINE; 3-(2-CARBOXYPIPERAZIN-4-YL)PROPYL-1-PHOSPHONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; MUSCARINIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CHOLINERGIC SYSTEM; CONTROLLED STUDY; HIPPOCAMPUS; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WORKING MEMORY; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; MEMORY; MICROINJECTION; PHYSIOLOGY; SYNAPTIC TRANSMISSION; WISTAR RAT;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; MEMORY; MICROINJECTIONS; MUSCARINIC AGONISTS; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SCOPOLAMINE; SEROTONIN ANTAGONISTS; SYNAPTIC TRANSMISSION;

EID: 0030583388     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00678-6     Document Type: Article

References (71)

1. [1] Abe, K., Nakata, A., Mizutani, A. and Saito, H., Facilitatory but nonessential role of the muscarinic cholinergic system in the generation of long-term potentiation of population spikes in the dentate gyrus in vivo, Neuropharmacology, 33 (1994) 847-852.
2. 4-like receptors mediate the slow excitatory response to serotonin in the rat hippocamppus, J. Pharmacol. Exp. Ther., 257 (1991) 930-937.
3. [3] Andrade, R. and Nicoll, R.A., Pharmaclogically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro, J. Physiol., 394 (1987) 99-124.
4. [4] Azmitia, E.G. and Segal, M., An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat, J. Comp. Neurol., 179 (1978) 641-668.
5. 1A-mediated hyperpolarization in CA1 and CA3 hippocampal pyramidal cells, J. Pharmacol. Exp. Ther., 263 (1992) 350-359.
6. [6] Brito, G.N.O. and Thomas, G.J., T-maze alternation, response patterning, and septo-hippocampal circuitry in rats, Behav. Brain Res., 3 (1981) 319-340.
7. [7] Brito, G.N.O., Davis, B.J., Stopp, L.C. and Stanton, M.E., Memory and the septo-hippocampal cholinergic system in the rat, Psychopharmacology, 81 (1983) 315-320.
8. 1A receptors, Br. J. Pharmacol., 105 (1992) 720-726.
9. 1A receptor agonist, impairs performance in a passive avoidance task, Eur. J. Pharmacol., 211 (1992) 227-234.
10. 1A receptors in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze, Brain Res., 595 (1992) 50-56.
11. 1A receptors causes amnesia and anxiolytic-like but not antidepressant-like effects in the rat, Eur. J. Pharmacol., 234 (1993) 215-221.
12. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine, Eur. J. Phrmacol., 283 (1995) 133-139.
13. 1A receptors in the hippocampus, Behav. Brain Res., 67 (1995) 67-74.
14. 1A receptor antagonist NAN-190 on rat brain serotonergic transmission, Eur. J. Pharmacol., 204 (1991) 71-77.
15. [15] Cole, A.E. and Nicoll, R.A., The pharmacology of cholinergic excitatory responses in hippocampal pyramidal cells. Brain Res., 305 (1984) 283-290.
16. [16] Colino, A. and Halliwell, J.V., Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin, Nature, 328 (1987) 73-77.
17. [17] Decker, M.W. and Gallagher, M., Scopolamine-disruption of radial arm maze performance: modification by noradrenergic depletion, Brain Res., 417 (1987) 59-69.
18. [18] Decker, M.W., Gill, T.M. and McGaugh, J.L., Concurrent muscarinic and β-adrenergic blockade in rats impairs place-learning in a water maze and retention of inhibitory avoidance. Brain Res., 513 (1990) 81-85.
19. [19] Eichenbaum H., Otto T. and Cohen E.J., The hippocampus - What does it do?, Behav. Neural Biol., 57 (1992) 2-36.
20. 1A receptors, Eur. J. Pharmacol., 237 (1993) 283-291.
21. [21] Francis, P.T., Sims, N.R., Procter, A.W. and Bowen, D.M., Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives, J. Neurochem., 60 (1993) 1589-1604.
22. 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), Eur. J. Pharmacol, 154 (1988) 339-341.
23. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro, Eur. J. Pharmacol, 211 (1992) 211-219.
24. 3H]8-Hydroxy-2-(di-n-propylamino)tetralin binding to pre-and postsynaptic 5-hydrpxytryptamine sites in various regions of the rat brain, J. Neurochem., 44 (1985) 1685-1696.
25. [25] Hirotsu, I., Hori, N., Katsuda, N. and Ishihara, T., Effect of anticholinergic drug on long-term potentiation in rat hippocampal slices, Brain Res., 482 (1989) 194-197.
26. 1A receptors: behavioural and in vivo brain microdialysis studies, Life Sci., 46 (1990) 955-963.
27. 1A receptor enhances acetylcholine release in conscious rats, J. Neurochem., 62 (1994) 1804-1808.
28. [28] Jarrard L.E., On the role of the hippocampus in learning and memory in the rat, Behav. Neural Biol., 60 (1993) 9-26.
29. [29] Kitajima, I., Yamamoto, T., Ohno, M. and Ueki, S., Working and reference memory in rats in the three-panel runway task following dorsal hippocampal lesions, Jpn. J. Pharmacol., 58 (1992) 175-183.
30. [30] Kobayashi, M., Ohno, M., Yamamoto, T. and Watanabe, S., Concurrent blockade of β-adrenergic and muscarinic receptors disrupts working memory but not reference memory in rats, Physiol. Behav., 58 (1995) 307-314.
31. [31] Mash, D.C. and Potter, L.T., Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain, Neuroscience, 19 (1986)551-564.
32. 1B receptors mediating inhibition of acetylcholine release, Eur. J. Pharmacol., 129 (1986) 333-337.
33. [33] Maura, G., Fedele, E. and Raiteri, M., Acetylcholine release from rat hippocampal slices is modulated by 5-hydroxytryptamine, Eur. J. Pharmacol., 165 (1989) 173-179.
34. [34] McNaughton, N. and Morris, R.G.M., Buspirone produces a dose-related impairment in spatial navigation, Pharmacol. Biochem. Behav., 43 (1992) 167-171.
35. 1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism, Eur. J. Pharmacol., 236 (1993) 177-182.
36. [36] Mesulam, M.-M., Mufson, E.J., Wainer, B.H. and Levey, A.I., Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6), Neuroscience, 10 (1983) 1185-1201.
37. 1A antagonists, J. Pharmacol. Exp. Ther., 268 (1994) 337-352.
38. [38] Nilsson, O.G., Strecker, R.E., Daszuta, A. and Björklund, A., Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat. Brain Res., 453 (1988) 235-246.
39. [39] Ohno, M. and Watanabe, S., Concurrent blockade of hippocampal metabotropic glutamate and N-methyl-D-aspartate receptors disrupts working memory in the rat, Neuroscience, 70 (1996) 303-311.
40. [40] Ohno, M., Yamamoto, T. and Watanabe, S., Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working memory and reference memory assessed in rats by a three-panel runway task, J. Pharmacol. Exp. Ther., 263 (1992) 943-950.
41. 1A receptor agonist, in the rat, Eur. J. Pharmacol., 234 (1993) 29-34.
42. [42] Ohno, M., Yamamoto, T., Kobayashi, M. and Watanabe, S., Impairment of working memory induced by scopolamine in rats with noradrenergic DSP-4 lesions, Eur. J. Pharmacol., 238 (1993) 117-120.
43. 1 muscarinic receptors impairs working memory performance of rats, Brain Res., 650 (1994) 260-266.
44. [44] Ohno, M., Yoshimatsu, A., Kobayashi, M. and Watanabe, S., Noradrenergic DSP-4 lesions aggravate impairment of working memory produced by hippocampal muscarinic blockade in rats, Pharmacol. Biochem. Behav., (1996) in press.
45. 2-adrenergic systems in the antagonizing effect of paeoniflorin on scopolamine-induced deficit in radial maze performance in rats, Jpn. J. Pharmacol., 62 (1993) 199-202.
46. [46] Oleskevich, S. and Descarries, L., Quantified distribution of the serotonin innervation in adult rat hippocampus, Neuroscience, 34 (1990) 19-33.
47. [47] Palmer, A.M., Francis, P.T., Benton, J.S., Sims, N.R., Mann, D.M.A., Neary, D., Snowden, J.S. and Bowen, D.M., Presynaptic serotonergic dysfunction in patients with Alzheimer's disease, J. Neurochem., 48 (1987) 8-15.
48. [48] Palmer, A.M., Stratmann, G.C., Procter, A.W. and Bowen, D.M., Possible neurotransmitter basis of behavioral changes in Alzheimer's disease, Ann. Neurol, 23 (1988) 616-620.
49. [49] Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1982.
50. [50] Pazos, A. and Palacios, J.M., Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors, Brain Res., 346 (1985) 205-230.
51. [51] Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H. and Perry, R.H., Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Br. Med. J., 2 (1978) 1457-1459.
52. [52] Richter-Levin, G. and Segal, M., Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission, Brain Res., 477 (1989) 404-407.
53. 1A and muscarinic acetylcholine receptors jointly regulate passive avoidance behavior, Eur. J. Pharmacol., 262 (1994) 77-90.
54. [54] Riekkinen, Jr., P., Sirviö, J. and Riekkinen, P., Interaction between raphe dorsalis and nucleus basalis magnocellularis in spatial learning, Brain Res., 527 (1990) 342-345.
55. [55] Riekkinen, Jr., P., Sirviö, J., Valjakka, A., Miettinen, R. and Riekkinen, P., Pharmacological consequences of cholinergic plus serotonergic manipulations, Brain Res., 552 (1991) 23-26.
56. [56] Riekkinen, M., Riekkinen, P., Sirviö, J. and Riekkinen, Jr., P., Effects of combined methysergide and mecamylamine/scopolamine treatment on spatial navigation, Brain Res., 585 (1992) 322-326.
57. 1A receptor agonist and a muscarinic acetylcholine receptor antagonist disrupts water maze navigation behavior, Psychopharmacology, 122 (1995) 137-146.
58. [58] Rowan, M.J., Cullen, W.K. and Moulton, B., Buspirone impairment of performance of passive avoidance and spatial learning tasks in the rat, Psychopharmacology, 100 (1990) 393-398.
59. 4 receptor colocalization on hippocampal pyramidal cells, Neuropharmacolgy, 33 (1994) 551-557.
60. 1A receptors, Brain Res., 532 (1990) 191-196.
61. 1A receptor in slices of the rat hippocampal dentate gyrus, Brain Res., 613 (1993) 326-330.
62. [62] Sakurai, Y. and Wenk, G.L., The interaction of acetylcholinergic and serotonergic neural systems on performance in a continuous non-matching to sample task, Brain Res., 519 (1990) 118-121.
63. 1A receptor antagonist, Eur. J. Pharmacol., 244 (1993) 251-257.
64. [64] Segal, M., Multiple actions of acetylcholine at a muscarinic receptor studied in the rat hippocampal slice, Brain Res., 246 (1982) 77-87.
65. [65] Vanderwolf, C.H., Near-total loss of 'learning' and 'memory' as a result of combined cholinergic and serotonergic blockade in the rat, Behav. Brain Res., 23 (1987) 43-57.
66. [66] Van Wijngaarden, I., Tulp, M.Th.M. and Soudijn, W., The concept of selectivity in 5-HT receptor research, Eur. J. Pharmacol., 188 (1990) 301-312.
67. 1A subtype, Eur. J. Pharmacol., 113 (1985) 463-464.
68. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats, J. Neurosci., 6 (1986) 3474-3482.
69. [69] Wilcock, G.K., Esiri, M.M., Bowen, D.M. and Smith, C.C.T., Alzheimer's disease: correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities, J. Neurol. Sci., 57 (1982) 407-417.
70. 1A receptors in memory, Pharmacol. Biochem. Behav., 27 (1987) 625-628.
71. [71] Zola-Morgan S., Squire L.R. and Amaral D.G., Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, J. Neurosci., 6 (1986) 2950-2967.