Intestinal absorption of vitamins

Current Opinion in Gastroenterology

Volumn 15, Issue 2, 1999, Pages 172-176

  Said, Hamid M ^a   Kumar, Chandira ^a  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; CELLULAR RETINOL BINDING PROTEIN; COBALAMIN; COMPLEMENTARY DNA; ENZYME; FOLIC ACID; INTRINSIC FACTOR; MESSENGER RNA; PANTOTHENIC ACID; POLYGLUTAMIC ACID; RECEPTOR; RETINOL; SODIUM; THIAMINE; VITAMIN;

APICAL MEMBRANE; CELL STRAIN CACO 2; CLONING; FOLATE METABOLISM; FOOD INTAKE; HUMAN; HUMAN TISSUE; INTESTINE ABSORPTION; INTESTINE BIOPSY; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LARGE INTESTINE; REVIEW; SMALL INTESTINE ABSORPTION; VITAMIN DEFICIENCY;

EID: 0033010536     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199903000-00015     Document Type: Review

References (22)

1. 1 Halsted CH, Ling E, Luthi-Carter R, Villanueva JA, Gardner JA, Coyle JT: Folyl-γ-glutamate carboxypeptidase from pig jejunum: molecular characterization and relation to glutamate carboxypeptidase II. J Biol Chem 1998, 273:20417-20424. This article reports on isolation of full-length cDNA clone of the folate polygtutamate hydrolyzing enzyme, FGCP, from pig intestine and its molecular characterization.
2. 2 Said HM, Nguyen TT, Dyer DL, Cowan KH, Rubin SA: Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA. Biochim Biophys Acta 1996, 1281:164-172.
3. 3 Nguyen TT, Dyer DL, Dunning DD, Rubin SA, Grant KE, Said HM: Human intestinal folate transport: cloning expression and distribution of complementary RNA. Gastroenterology 1997, 112:783-791. Molecular identification of the folate transporter of human small intestine. By in situ hybridization, transcripts of this clone were found to be more abundant in the epithelial cells of the villi than those of the crypt.
4. 4 Kumar CK, Nguyen TT, Gonzales FB, Said HM: Comparison of intestinal folate carrier clone expressed in IEC-6 cells and in Xenopus oocytes. Am J Physiol 1998, 274:C289-C294. This study shows characteristics of the folate transporter RFC-1 to be different depending on the cellular system in which the clone is expressed. This is possibly occurring because of existence of a cell-specific posttranslational modification mechanisms, an auxiliary protein that modulates the activity of RFC-1, or differences in membrane composition of the different cells.
5. 5 Said HM, Ma TY, Ortiz A, Tapia A, Valerio C: Intracellular regulation of intestinal folate uptake: studies with cultured IEC-6 epithelial cells. Am J Physiol 1997, 272:C729-C736. Showed the intestinal folate uptake process to be under possible regulation by a protein-tyrosine kinase and a cAMP-mediated pathway.
6. 6 Kumar CK, Moyer MP, Dudeja PK, Said HM: A protein-tyrosine kinase-regulated, pH-dependent, carrier-mediated uptake system for folate in human normal colonic epithelial cell line NCM460. J Biol Chem 1997, 272:6226-6231. Demonstrated the existence of a specialized, carrier-mediated system in colonocytes that appears to bo under the regulation of an intracellular protein-tyrosine kinase and a cAMP-mediated pathway.
7. 7 Dudeja PK, Torania S, Said HM: Evidence for the existence of a carrier-mediated folate uptake mechanism in human colonic luminal membranes. Am J Physiol 1997, 272:G1408-G1415. Purified colonic apical membrane vesicles isolated from the colon of human organ donors were used to demonstrate the existence of a pH-dependent, DIDS-sensitive, electroneutral carrier-mediated mechanism for folate uptake in the colon.
8. 8 Houghton LA, Green TJ, Donovan UM, Gibson RS, Stephen AM, O'Connor DL: Association between dietary fiber intake and the folate status of a group of female adolescents. Am J Clin Nutr 1997, 66:1414-1421. Demonstrated the existence of a significant positive association between serum folate concentrations and the consumption of nonstarch polysaccharide in a group of female adolescents.
9. 9 Wen J, Gordon MM, Alpers DH: A receptor binding site on intrinsic factor is located between amino acids 25-44 and interacts with other parts of the protein. Biochem Biophys Res Commun 1997, 231:348-351. Identified a binding region in the IF that is involved in the binding of this protein to its receptor; the study also suggested that additional sites may be involved in the binding.
10. 10 Eaton DM, Livinston JH, Seetharam B, Puntis JWL: Over expression of an unstable intrinsic factor-cobalamine receptor in Imerslund-Grasbeck syndrome. Gastroenterology 1998, 115:173-176. Cbl deficiency in Imerslund-Gräsbeck syndrome is due to a new phenotype of overexpression of an active but unstable IFCR; this is in contrast to the previous reports of decreased IFCR activity in this condition.
11. 11 Seetharam B, Christensen El, Moestrup SK, Hammond TG, Verrous PJ: Identification of rat yolk sac target protein of teratogenic antibody, gp280, as intrinsic factor-cobalamine receptor. J Clin Invest 1997, 99:2317-2322. Showed gp280 and IF-cobalamine receptor (IFCR) to be identical proteins and IF-Cbl to be a ligand for gp280.
12. 12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 1998, 273:5235-5242. This study shows the molecular characterization of the rat 460-kDa intestinal and renal epithelial glycoprotein that functions as a receptor to facilitate the uptake of IF-Cbl complex.
13. 13 Said HM, Redha R, Nylander W: A carrier-mediated, Na gradient-dependent transport for biotin in human intestinal brush border membrane vesicles. Am J Physiol 1987, 253:G631-G636.
14. 14 Ma TY, Dyer DL, Said HM: Human intestinal cell line Caco-2: a useful model for studying cellular and molecular regulation of biotin uptake. Biochim Biophys Acta 1994, 1189:81-88.
15. 15 Said HM: Cellular uptake of biotin: mechanism and regulation. J Nutr 1999 (in press). This article reviews current knowledge of biotin intestinal transport and presents new data on the regulation of biotin intestinal uptake by a protein kinase C and a CA/calmodulin-mediated pathway.
16. +-dependent system for biotin uptake by colonocytes. It also shows that this system is shared with another bacterially synthesized water-soluble vitamin, pantothenic acid, and appears to be under the cellular regulation of a protein kinase C-mediated pathway.
17. 17 Prasad PD, Wang H, Kekuda R, Fujita T, Feis YJ, Devoe LD, et al: Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. J Biol Chem 1998, 273:7501-7506.
18. 18 Prasad PD, Sheikh S, Huang W, Leibach FH, Ganapathy V: Cloning of a functional sodium-dependent pantothenate/biotin transporter from rabbit intestine and Caco-2 cells [Abstract]. FASEB J 1998, 12:A1042. This abstract reports the cloning of a pantothenic acid/biotin intestinal transporter.
19. 19 Laforenza U, Patrini C, Alvisi C, Faelli A, Licandro A, Rindi G: Thiamin uptake in human intestinal biopsy specimens, including observations from a patient with acute thiamine deficiency. Am J Clin Nutr 1997, 66:320-326. Demonstrated the existence of a carrier-mediated mechanism for thiamin uptake by human intestinal biopsy specimens. Showed that in a thiamin-deficient patient, thiamin uptake was higher compared to controls.
20. 20 Dew SE, Ong DE: Absorption of retinol from the retinol: retinol-binding protein complex by small intestinal gut sheets from the rat. Arch Biochem Biophys 1997, 338:233-236. Provided evidence to suggest the existence of a specific mechanism for the absorption of retinol-bound to retinol-binding protein in the small intestine of suckling rats.
21. 21 Said HM, Ong DE, Singleton JL: Intestinal uptake of retinol enhancement by bovine milk β-lactoglobulin. Am J Clin Nutr 1989, 49:690-694.
22. 22 Levin MS, Davis AE: Retinoic acid increases cellular retinol binding protein II mRNA and retinol uptake in the human intestinal Caco-2 cell line. J Nutr 1997, 127:13-17. Provided evidence that retinoids may regulate vitamin A intestinal absorption by demonstrating a positive effect of retinoic acid on expression of cellular retinol-binding protein II (CRBP II) and retinol uptake by the human-derived intestinal epithelial cells Caco-2.