Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 7, 1999, Pages 1425-1436

  Parmar, Virinder S ^a   Kumar, Ajay ^a   Prasad, Ashok K ^a   Singh, Sanjay K ^a   Kumar, Naresh ^a   Mukherjee, Shubhasish ^a   Raj, Hanumantharao G ^b   Goel, Sanjay ^b   Errington, William ^c   Puar, Mohindar S ^d  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF DELHI   (India)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antioxidants; Arylpyrazoles; Isomerisation; Lipid peroxidation; Pyrazolylacrylonitriles

Indexed keywords

ANTIOXIDANT; PYRAZOLYLACRYLONITRILE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG SYNTHESIS; ISOMERISM; LIPID PEROXIDATION; LIVER MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACRYLONITRILE; ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, THIN LAYER; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; ISOMERISM; LIPID PEROXIDATION; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NADP; PYRAZOLES; RATS; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033008650     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00056-5     Document Type: Article

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