Dysregulation of B7.2 (CD86) expression on monocytes of HIV-infected individuals is associated with altered production of IL-2

Clinical and Experimental Immunology

Volumn 117, Issue 1, 1999, Pages 84-91

  Kumar, A ^a,b   Angels, J B ^b   Aucoin, S ^a   Creery, W D ^b   Daftarian, M P ^a   Cameron, D W ^b   Filion, I ^b   Diaz Mitoma, F ^a,b  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

B7; Cytokines; HIV 1

Indexed keywords

CD86 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; ANTIGENS, CD; ANTIGENS, CD86; B-LYMPHOCYTES; GENE EXPRESSION REGULATION; HIV INFECTIONS; HUMANS; INTERLEUKIN-10; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COOPERATION; MEMBRANE GLYCOPROTEINS; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033007506     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00937.x     Document Type: Article

References (44)

1. Fauci AS. Host factors and the pathogenesis of HIV-induced disease. Nature 1996; 384:529-34.
2. Clerici M, Hakim FT, Venzon DJ et al. Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals. J Clin Invest 1993; 91:759-65.
3. Clerici M, Stocks NI, Zajac RA et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immuno-deficiency virus-seropositive patients, Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989; 84:1892-9.
4. June CH, Bluestone JA, Nadler LM, et al. The B7 and CD28 receptor families. Immunol Today 1994; 15:321-31.
5. Thompson CB. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 1995; 81:979-82.
6. Brinchmann JF, Dobloug JH, Heger BH et al. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: Functional and clinical correlations. J Infect Dis 1994; 169:730-8.
7. Zanussi S, Simonelli C, D'Andrea M et al. CD8+ lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infection. Clin Exp Immunol 1996; 105:220-4.
8. Boussiotis VA, Freeman GJ, Gribben JG et al. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci USA 1993; 90:11059-63.
9. Lenschow DJ, Ho SC, Sattar H et al. Differential effects of anti-B7-1 and anti B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995; 181:1145-55.
10. Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80:707-18.
11. Freeman GJ, Boussiotis VA, Anumanthan A et al. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 1995; 2:523-32.
12. Creery WD, Diasz-Mitoma F, Filion L et al. Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence thc development of T helper cell phenotype. Eur J Immunol 1996; 26:1273-7.
13. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today 1994; 15:57581.
14. Clerici M, Wynn TA, Berzofsky JA et al. Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest 1994; 93:768-75.
15. Diaz-Mitoma F, Kumar A, Karimi S et al. Expression of IL-10, IL-4 and interferon-gamma in unstimulated and mitogen-stimulated peripheral blood lymphocytes from HIV-seropositive patients. Clin Exp Immunol 1995; 102:31-39.
16. Meyaard L, Hovenkamp E, Keet TP et al. Single cell analysis of IL-4 and IFN-gamma production hy T cells from HIV-infected individuals: Decreased IFN-gamma in the presence of preserved IL-4 production. J Immunol 1996; 157:2712-8.
17. Emilie D, Fior R, Llorente L et al. Cytokines from lymphoid organs of HIV-infected patients: production and role in the immune disequilibrium of the disease and in the development of B lymphomas. Immunol Rev 1994; 140:534.
18. Maggi E, Mazzetti M, Ravina A et al. Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells. Science 1994; 265:244-8.
19. Kumar A, Angel J, Daftarian MP et al. Differential production of IL-10 by T cells and monocytes of HIV-infected individuals: Association of IL-10 production with CD28-mediated immune responsiveness. Clin Exp Immunol 1998; 114:78-86.
20. Ding L, Linsley PS, Huang LY et al. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151:1224-34.
21. de Waal Malefyt R, Haanen J, Spits H et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J Exp Med 1991; 174:915-24.
22. Daftarian PM, Kumar A, Kryworuchko M et al. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. J Immunol 1996; 157:12-20.
23. Buelens C, Willems F, Delvaux A et al. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25:2668-72.
24. Vyakarnam A, Matear P, Meager A et al. Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals. Clin Exp Immunol 1991; 84:109-15.
25. Wetzler LW, Ho Y, Reiser H. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J Exp Med 1996; 183:1151-9.
26. Kaye PM, Rogers NJ, Curry AJ et al. Deficient expression of costimulatory molecules on Leishmania-infected macrophages. Eur J Immunol 1994; 24:2850-4.
27. Saha B, Das G, Vohra H et al. Macrophage-T cell interaction in experimental mycobacterial infection. Selective regulation of co- stimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response. Eur J Immunol 1994; 24:2618-24.
28. Wyss-Coray T, Mauri-Hullweg D, Baumann K et al. The B7 adhesion molecule is expressed on activated human T cells: Functional involvement in T-T cell interactions. Eur J Immunol 1993; 23:2175-80.
29. Wolthers KC, Otto SA, Lens SM et al. Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: Regulation by CD4+ T cells. Eur J Immunol 1996; 26:1700-6.
30. Haffar OK, Smithgall MD, Bradshaw J et al. Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donors. Proc Natl Acad Sci USA 1993; 90:11094-8.
31. Low P, Weber C, Harrer F, et al. CD80 expression on monocytes in HIV-infected patients. J Acquir Immune Defic Syndr Hum Retrovir 1997; 15:264-8.
32. Larsen CP, Ritchie SC, Pearson TC et al. Functional expression of the costimulatory molecule B7/BB1, on murine dendritic cell populations. J Exp Med 1992; 176:1215-20.
33. Wu TC, Huang AYC, Jaffee EM et al. A reassessment of the role of B71 expression in tumor rejection. J Exp Med 1995; 182:1415-21.
34. Chirmule N, McCloskey TW, Hu R et al. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). J Immunol 1995; 155:917-24.
35. Van Parijs L, Sethna MP, Schweitzer AN et al. Functional consequences of dysregulated BT-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J Immunol 1997; 159:5336-44.
36. von Herrath MG, Guerder S, Lewicki H et al. Coexpression of B7-1 and viral ('self') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity 1995; 3:727-38.
37. Del Prete G, De Carli M, Almerigogna F et al. Human IL-10 is produced by both type 1 helper (Th1) anti type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993; 150:35360.
38. Groux H, Bigler M, de Vries JE et al. Interleukin-10 induces a long-term antigen-specific anergie state in human CD4+ T cells. J Exp Med 1996; 184:19-29.
39. Brown JA, Titus RO, Nabavi N et al. Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response. J Infect Dis 1996; 174:1303-8.
40. Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996; 183:2533-40.
41. Freeman GJ, Borriello F, Hodes RJ et al. Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med 1993; 178:2185-92.
42. Reiser H, Freeman GJ, Razi-Wolf Z et al. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci USA 1992; 89:271-5.
43. Chehimi J, Starr RE, Frank J et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994; 179:1361-6.
44. Angel JB, Kumar A, Parato K et al. Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir. J Infect Dis 1998; 177:898-904.