Glycated albumin stimulation of PKC-β activity is linked to increased collagen IV in mesangial cells

American Journal of Physiology - Renal Physiology

Volumn 276, Issue 5 45-5, 1999, Pages

  Cohen, Margo P ^a   Ziyadeh, Fuad N ^b   Lautenslager, Gregory T ^a   Cohen, Jonathan A ^a   Shearman, Clyde W ^a  

^a The Science Center Philadelphia   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Amadori; Diabetic nephropathy; Glucose; Glycation; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ALBUMIN; COLLAGEN TYPE 4; GLUCOSE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GLYCATION; KIDNEY DISEASE; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033006967     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1999.276.5.f684     Document Type: Article

References (43)

1. Aiello, L. P., S.-E. Bursell, A. Clermont, E. Duh, H. Ishii, C. Takagi, F. Mori, T. A. Ciulla, K. Ways, M. Jirousek, L. E. H. Smith, and G. L. King. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes 46: 1473-1480, 1997.
2. Ayo, S. H., R. A. Radnik, T. Garoni, A. Koyer, and J. I. Kreisberg. High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F571-F577, 1991.
3. Babazono, T., J. Kapor-Drezyic, J. A. Dlugosz, and C. Whiteside. Altered expression and subcellular distribution of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells. Diabetes 47: 668-676, 1998.
4. Chung, K. Y., A. Agarwal, J. Uitto, and A. Mauviel. An AP-1 binding sequence is essential for regulation of the human α2(I) collagen (COL1A2) promoter activity by transforming growth factor-β. J. Biol. Chem. 271: 3272-3278, 1996.
5. Cohen, M. P. Diabetes and Protein Glycation. Clinical and Pathophysiologic Relevance. Philadelphia, PA: JC Press, 1996.
6. Cohen, M. P., R. S. Clements, J. A. Cohen, and C. W. Shearman. Prevention of decline in renal function in the diabetic db/db mouse. Diabetologia 39: 270-274, 1996.
7. Cohen, M. P., and E. Hud. Measurement of plasma glycoalbumin levels with a monoclonal antibody-based ELISA. J. Immunol. Methods 122: 279-283, 1989.
8. Cohen, M. P., and F. N. Ziyadeh. Role of Amadori-modified nonenzymatically glycated serum proteins in the pathogenesis of diabetic nephropathy. J. Am. Soc. Nephrol. 7: 183-190, 1996.
9. Cohen, M. P., E. Hud, V. Y. Wu, and F. N. Ziyadeh. Albumin modified by Amadori glucose adducts activates mesangial cell type IV collagen gene transcription. Mol. Cell. Biochem. 151: 61-67, 1995.
10. Cohen, M. P., K. Sharma, Y. Jin, E. Hud, V. Y. Wu, J. Tomaszewski, and F. N. Ziyadeh. Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists: a novel treatment strategy. J. Clin. Invest. 95: 2338-2345, 1995.
11. Cohen, M. P., and V. Y. Wu. Evidence for a ligand receptor system mediating the biologic effects of glycated albumin in glomerular mesangial cells. Biochem. Biophys. Res. Commun. 207: 521-528, 1995.
12. Cohen, M. P., V. Y. Wu, and J. A. Cohen. Glycated albumin stimulates fibronectin and collagen IV production by glomerular endothelial cells under normoglycemic conditions. Biochem. Biophys. Res. Commun. 239: 91-94, 1997.
13. Cohen, M. P., and F. N. Ziyadeh. Amadori glucose adducts modulate mesangial cell growth and collagen gene expression. Kidney Int. 45: 475-484, 1994.
14. Craven, P. A., C. M. Davidson, and F. R. DeRubertis. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 39: 667-674, 1990.
15. Craven, P. A., R. K. Studer, J. Felder, S. Phillips, and F. R. DeRubertis. Nitric oxide inhibition of transforming growth factor-β and collagen in mesangial cells. Diabetes 46: 671-681, 1997.
16. DeRubertis, F. R., and P. A. Craven. Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 43: 1-8, 1994.
17. Fumo, R., G. S. Kuncio, and F. N. Ziyadeh. PKC and high glucose stimulate collagen α1(IV) transcriptional activity in a reporter mesangial cell line. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F632-F638, 1994.
18. Ganz, M. B., B. Saksa, R. Saxena, K. Hawkins, and J. R. Sedor. PDGF and IL-1 induce and activate specific protein kinase C isoforms in mesangial cells. Am. J. Physiol. 271 (Renal Physiol. 40): F108-F113, 1996.
19. Gille, H., A. D. Sharrocks, and P. K. Shaw. Phosphorylation of transcription factor p62 TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358: 414-417, 1992.
20. Guzman, M. J., P. Kurian, V. J. Andaloro, C. C. Tisher, and F. T. Grews. Effect of glucose in receptor-mediated phosphoinositide hydrolysis and second messenger generation in rat glomerular mesangial cells. J. Am. Soc. Nephrol. 2: 179-190, 1992.
21. Haneda, M., S. Araki, M. Togawa, T. Sugimoto, M. Isono, and R. Kikkawa. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes 46: 847-853, 1997.
22. Haneda, M., R. Kikkawa, N. Horide, M. Togawa, D. Koya, N. Kajiwara, A. Ooshima, and Y. Shigeta. Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells. Diabetologia 34: 198-200, 1991.
23. Hoffman, B. B., K. Sharma, Y. Zhu, F. N. Ziyadeh. Transcriptional activation of TGF-β1 in mesangial cell culture by high glucose concentration. Kidney Int. 54: 1107-1116, 1998.
24. Huwiler, A., E. Schulze-Lohoff, D. Fabbro, and J. Pfeilschifter. Immunocharacterization of protein kinase C isoenzyme in rat kidney glomeruli and cultured glomerular epithelial and mesangial cells. Exp. Nephrol. 1: 19-25, 1993.
25. Inoguchi, T., R. Battan, E. Handler, J. R. Sportsman, W. Heath, and G. L. King. Preferential activation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility of glycemic control by islet cell transplantation. Proc. Natl. Acad. Sci. USA 89: 11059-11063, 1992.
26. Ishii, H., M. R. Jirousek, D. Koya, C. Tagaki, P. Xia, A. Clermont, S.-E. Bursell, T. S. Kern, L. M. Ballas, W. F. Heath, L. E. Stramm, E. P. Fiener, and G. L. King. Amelioration of vascular dysfunction in diabetic rats by an oral PKC inhibitor. Science 272: 728-731, 1996.
27. Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. Activation of ternary complex factor Elk-1 by MAP kinases. EMBOJ. 12: 5097-5104, 1993.
28. Jirousek, M. R., J. R. Gillig, C. M. Gonzalez, W. F. Heath, J. H. McDonald III, D. A. Neel, C. J. Rito, U. Singh, L. E. Stramm, A. Melikian-Badalian, M. Baevsky, L. M. Ballas, S. E. Hall, L. L. Winneroski, and M. M. Faul. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase Cβ. J Med. Chem. 39: 2664-2671, 1996.
29. Kikkawa, R., M. Haneda, T. Uzu, D. Koya, T. Sugimoto, and Y. Shigeta. Translocation of protein kinase C α and ζ in rat glomerular mesangial cells cultured under high glucose conditions. Diabetologia 37: 838-841, 1994.
30. Koya, D., M. R. Jirousek, Y.-W. Lin, H. Ishii, K. Kuboki, and G. L. King. Characterization of protein kinase C-β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J. Clin. Invest. 100: 115-126, 1997.
31. Kreisberg, J. I., A. Radnik, S. H. Ayo, J. Garoni, and P. Saikumar. High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures. Kidney Int. 46: 105-112, 1994.
32. Nishizuka, Y. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614, 1992.
33. Porte, D., and M. W. Schwartz. Diabetes complications: why is glucose potentially toxic? Science 272: 699-700, 1996.
34. Silbiger, S., J. Lei, F. N. Ziyadeh, and J. Neugarten. Estradiol reverses TGF-β1-stimulated type IV collagen gene transcription in murine mesangial cells Am. J. Physiol. 274 (Renal Physiol. 43): F1113-F1118, 1998.
35. Studer, R. K., P. A. Craven, and F. R. DeRubertis. Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high glucose medium. Diabetes 42: 118-126, 1993.
36. Thomas, T. P., R. Gopalakrishna, and W. B. Anderson. Hormone- and tumor promoter-induced activation of membrane association of protein kinase C in intact cells. Methods Enzymol. 141: 399-411, 1987.
37. Williams, B., and R. W. Schrier. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells. Diabetes 41: 1464-1472, 1992.
38. Wolf, G., K. Sharma, Y. Chen, M. Ericksen, and F. N. Ziyadeh. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int. 42: 647-656, 1992.
39. Ziyadeh, F. N., and M. P. Cohen. Effects of glycated albumin on mesangial cells: evidence of a role in diabetic nephropathy. Mol. Cell. Biochem. 125: 19-25, 1993.
40. Ziyadeh, F. N., P. Fumo, C. H. Rodenberger, G. S. Kuncio, and E. G. Neilson. Role of protein kinase C and cyclic AMP/ protein kinase A in high glucose-stimulated transcriptional activation of collagen α1(IV) in glomerular mesangial cells. J. Diabetes Complications 9: 255-261, 1995.
41. Ziyadeh, F. N., D. C. Han, J. A. Cohen, J. Guo, and M. P. Cohen. Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: involvement of the transforming growth factor-β. Kidney Int. 53: 631-638, 1998.
42. Ziyadeh, F. N., K. Sharma, M. Ericksen, and G. Wolf. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activity of transforming growth factor-β. J. Clin. Invest. 93: 536-542, 1994.
43. Ziyadeh, F. N., E. R. Snipes, M. Watanabe, R. J. Alvarez, S. Goldfarb, and T. P. Haverty. High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F704-F714, 1990.