Intravascular and interstitial degradation of bradykinin in isolated perfused rat heart

British Journal of Pharmacology

Volumn 122, Issue 6, 1997, Pages 1179-1187

  Dendorfer, Andreas ^a   Wolfrum, Sebastian ^a   Wellhöner, Peter ^a   Korsman, Katja ^a   Dominiak, Peter ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Aminopeptidase P; Angiotensin I converting enzyme; Apstatin; Bradykinin; Heart; Kinin metabolism; Kininases; Neutral endopeptidase

Indexed keywords

AMINOPEPTIDASE P; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV; DIPROTIN A; DRUG METABOLIZING ENZYME; ENKEPHALINASE INHIBITOR; KININASE; MERCAPTOETHANOL; PHOSPHORAMIDON; RAMIPRILAT; TRITIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE METABOLISM; ISOLATED HEART; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BRADYKININ; MALE; MYOCARDIUM; PEPTIDES; PROTEASE INHIBITORS; RAMIPRIL; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; TRITIUM;

EID: 0030831912     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701501     Document Type: Article

References (39)

1. AHMAD, S. & WARD, P.E. (1992). Depressor action of bradykinin agonists relative to metabolism by angiotensin-converting enzyme, carboxypeptidase N, and aminopeptidase P. Proc. Soc. Exp. Biol. Med., 200, 115-121.
2. AUCH-SCHWELK, W., BOSSALLER, C., CLAUS, M., GRAF, K., GRÄFE, M. & FLECK, E. (1993). ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin. Cardiovasc. Res., 27, 312-317.
3. BAUMGARTEN, C.R., LINZ, W., KUNKEL, G., SCHÖLKENS, B.A. & WIEMER, G. (1993). Ramiprilat increases bradykinin outflow from isolated perfused rat hearts. Br. J. Pharmacol., 108, 293-295.
4. BHOOLA, K.D., FIGUEROA, C.D. & WORTHY, K. (1992). Bioregulation of kinins: Kallikreins, kininogens, and kininases. Pharmacol. Rev., 44, 1-80.
5. BÖNNER, G., PREIS, S., SCHUNK, U., TOUSSAINT, C. & KAUFMANN, W. (1990). Hemodynamic effects of bradykinin on systemic and pulmonary circulation in healthy and hypertensive humans. J. Cardiovasc. Pharmacol., 15(Suppl. 6), S46-S56.
6. CONNELLY, J.C., SKIDGEL, R.A., SCHULZ, W.W., JOHNSON, A.R. & ERDÖS, E.G. (1985). Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide. Proc. Natl. Acad. Sci. U.S.A., 82, 8737-8741.
7. DENDORFER, A., VORDERMARK, D. & DOMINIAK, P. (1997). Degradation of bradykinin by bovine tracheal epithelium and isolated epithelial cells. Br. J. Pharmacol., 120, 121-129.
8. DORER, F.E., KAHN, J.R., LENTZ, K.E., LEVINE, M. & SKEGGS, L.T. (1974). Hydrolysis of bradykinin by angiotensin-converting enzyme. Circ. Res., 34, 824-827.
9. DOSTAL, D.E., ROTHBLUM, K.N., CONRAD, K.M., COOPER, G.R. & BAKER, K.M. (1992). Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts. Am. J. Physiol., 263, C851-C863.
10. DRAPEAU, G., CHOW, A. & WARD, P.E. (1991). Metabolism of bradykinin analogs by angiotensin I converting enzyme and carboxypeptidase N. Peptides, 12, 631-638.
11. GAFFORD, J.T., SKIDGEL, R.A., ERDÖS, E.G. & HERSH, L.B. (1983). Human kidney 'enkephalinase', a neutral metalloendopeptidase that cleaves active peptides. Biochemistry, 22, 3265-3271.
12. GRAF, K., KOEHNE, P., GRÄFE, M., ZHANG, M., AUCH-SCHWELK, W. & FLECK, E. (1995). Regulation and differential expression of neutral endopeptidase 24.11 in human endothelial cells. Hypertension, 26, 230-235.
13. HECKER, M., PÖRSTI, I., BARA, A.T. & BUSSE, R. (1994). Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level. Br. J. Pharmacol., 111, 238-244.
14. HIRSCH, A.T., TALSNESS, C.E., SCHUNKERT, H., PAUL, M. & DZAU, V.J. (1991). Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ. Res., 69, 475-482.
15. HOOPER, N.M., HRYSZKO, J., OPPONG, S.Y. & TURNER, A. (1992). Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P. Hypertension, 19, 281-285.
16. ISHIDA, H., SCICLI, A.G. & CARRETERO, O.A. (1989). Contributions of various rat plasma peptidases to kinin hydrolysis. J. Pharmacol. Exp. Ther., 251, 817-820.
17. KITAMURA, S., CARBINI, L.A., CARRETERO, O.A., SIMMONS, W.H. & SCICLI, A.G. (1995). Potentiation by aminopeptidase P of blood pressure response to bradykinin. Br. J. Pharmacol., 114, 6-7.
18. LINZ, W., WIEMER, G., GOHLKE, P., UNGER, T. & SCHÖLKENS, B.A. (1995). Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol. Rev., 47, 25-49.
19. LLORENS-CORTES, C., HUANG, H., VICART, P., GASC, J.M., PAULIN, D. & CORVOL, P. (1992). Identification and characterization of neutral endopeptidase in endothelial cells from venous or arterial origins. J. Biol. Chem., 267, 14012-14018.
20. MASSOUDY, P., BECKER, B.F. & GERLACH, E. (1995). Nitric oxide accounts for postischemic cardioprotection resulting from angiotensin-converting enzyme inhibition: indirect evidence for a radical scavenger effect in isolated guinea pig heart. J. Cardiovasc. Pharmacol., 25, 440-447.
21. MINSHALL, R.D., YELAMANCHI, V.P., DJOKOVIC, A., MILETICH, D.J., ERDÖS, E.G., RABITO, S.F. & VOGEL, S.M. (1994). Importance of sympathetic innervation in the positive inotropic effects of bradykinin and ramiprilat. Circ. Res., 74, 441-447.
22. MOMBOULI, J.V., ILLIANO, S., NAGAO, T., SCOTT-BURDEN, T. & VANHOUTTE, P.M. (1992). Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors. Circ. Res., 71, 137-144.
23. MOMBOULI, J.V. & VANHOUTTE, P.M. (1992). Heterogeneity of endothelium-dependent vasodilator effects of angiotensin-converting enzyme inhibitors: role of bradykinin generation during ACE-inhibition. J. Cardiovasc. Pharmacol., 20(Suppl. 9), S74-S82.
24. MRÁZKOVÁ, O., GRIM, M. & CARLSON, B.M. (1986). Enzymatic heterogeneity of the capillary bed of rat skeletal muscles. Am. J. Anatomy, 177, 141-148.
25. NOLLY, H., CARBINI, L.A., SCICLI, G., CARRETERO, O.A. & SCICLI, A.G. (1994). A local kallikrein-kinin system is present in rat hearts. Hypertension, 23, 919-923.
26. ORAWSKI, A.T., SUSZ, J.P. & SIMMONS, W.H. (1989). Metabolism of bradykinin by multiple coexisting membrane-bound peptidases in the lung: techniques for investigating the role of each peptidase using specific inhibitors. Adv. Exp. Med. Biol., 247B, 355-364.
27. PESQUERO, J.B., JUBILUT, G.N., LINDSEY, C.J. & PAIVA, A.C.M. (1992). Bradykinin metabolism pathway in the rat pulmonary circulation. J. Hypertens., 10, 1471-1478.
28. PIEDIMONTE, G., NADEL, J.A., LONG, C.S. & HOFFMAN, J.I. (1994). Neutral endopeptidase in the heart. Neutral endopeptidase inhibition prevents isoproterenol-induced myocardial hypoperfusion in rats by reducing bradykinin degradation. Circ. Res., 75, 770-779.
29. PRECHEL, M.M., ORAWSKI, A.T., MAGGIORA, L.L. & SIMMONS, W.H. (1995). Effects of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung. J. Pharmacol. Exp. Ther., 275, 1136-1142.
30. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1987). The antiaggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol., 92, 639-646.
31. RYAN, J.W., BERRYER, P., CHUNG, A.Y.K. & SHEFFY, D.H. (1994). Characterization of rat pulmonary vascular aminopeptidase P in vivo: role in the inactivation of bradykinin. J. Pharmacol. Exp. Ther., 269, 941-947.
32. RYAN, J.W., PAPAPETROPOULOS, A., JU, H., DENSLOW, N.D., ANTONOV, A., VIRMANI, R., KOLODGIE, F.D., GERRITY, R.G. & CATRAVAS, J.D. (1996). Aminopeptidase P is disposed on human endothelial cells. Immunopharmacology, 32, 149-152.
33. RYAN, J.W., VALIDO, F., BERRYER, P., CHUNG, A.Y.K. & RIPKA, J. E. (1992). Purification and characterization of guinea pig serum aminoacylproline hydrolase (aminopeptidase P). Biochim. Biophys. Acta, 1119, 141-147.
34. SCHARPE, S.L., VANHOOF, G.C., DE MEESTER, I.A., HENDRIKS, D.F., VAN SANDE, M.E., MUYLLE, L.M. & YARON, A. (1991). Exopeptidases in human platelets: an indication for proteolytic modulation of biologically active peptides. Clin. Chim. Acta, 195, 125-131.
35. SCHUNKERT, H., DZAU, V.J., TANG, S.S., HIRSCH, A.T., APSTEIN, C.S. & LORELL, B.H. (1990). Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy: effects on coronary resistance, contractility, and relaxation. J. Clin. Invest., 86, 1913-1920.
36. SCHWIELER, J.H., KAHAN, T., NUSSBERGER, J. & HJEMDAHL, P. (1993). Converting enzyme inhibition modulates sympathetic neurotransmission in vivo via multiple mechanisms. Am. J. Physiol., 264, E631-E637.
37. VANHOOF, G., DE MEESTER, I., VAN SANDE, M., SCHARPE, S. & YARON, A. (1992). Distribution of proline-specific aminopeptidases in human tissue and body fluids. Eur. J. Clin. Chem. Clin. Biochem., 30, 333-338.
38. WARD, P.E., CHOW, A. & DRAPEAU, G. (1991). Metabolism of bradykinin agonists and antagonists by plasma aminopeptidase P. Biochem. Pharmacol., 42, 721-727.
39. YAMADA, H., FABRIS, B., ALLEN, A.M., JACKSON, B., JOHNSTON, C.I. & MENDELSOHN, A.O. (1991). Localization of angiotensin converting enzyme in rat heart. Circ. Res., 68, 141-149.