Phosphatidylethanolamine and phosphatidylcholine are sources of diacylglycerol in ras-transformed NIH 3T3 fibroblasts

International Journal of Biochemistry and Cell Biology

Volumn 31, Issue 2, 1999, Pages 311-318

  Momchilova, Albena ^a   Markovska, Tania ^a  

^a INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING   (Bulgaria)

Author keywords

Diacylglycerol; Fibroblasts; Phosphatidylcholine; Phosphatidylethanolamine; Ras

Indexed keywords

DIACYLGLYCEROL; FATTY ACID; GLYCEROL; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C; PHOSPHOLIPASE D;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; FIBROBLAST; GENE EXPRESSION; NONHUMAN; ONCOGENE RAS; RAT; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; DIGLYCERIDES; FATTY ACIDS; GENES, RAS; MICE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PHOSPHOLIPIDS;

EID: 0033004404     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(98)00111-3     Document Type: Article

References (29)

1. Barbacid M. Ras genes. Annu. Rev. Biochem. 56:1987;779-827.
2. Khosravi-Far R., Der C.J. The ras signal transduction pathway. Cancer Metastasis Rev. 13:1994;67-89.
3. Divecha N., Irvine R.F. Phospholipid signaling. Cell. 80:1995;269-278.
4. Lacal J.C., Moscat J., Aaronson S.A. Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature. 330:1987;269-272.
5. Price B.O., Morris J.D.H., Marshall C.J., Hall A. Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation. J. Biol. Chem. 264:1989;16638-16643.
6. Fleischman L.F., Chahwala S.B., Cantley L. Ras-transformed cells: altered levels of phosphatidylinositol-4-5 bisphosphate and catabolites. Science. 231:1986;407-410.
7. Exton J.H. Signalling through phosphatidylcholine breakdown. J. Biol. Chem. 256:1990;1-4.
8. Carnero A., Cuadrado A., del Peso L., Lacal J.C. Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH 3T3 cells. Oncogene. 9:1994;1387-1395.
9. Der C.J., Finkel T., Cooper J.M. Biological and biochemical properties of human ras-H genes mutated at codon 61. Cell. 44:1986;167-176.
10. Der C.J., Weissman B., MacDonald M.J. Altered guanine nucleotide binding and Ha-ras transforming and differentiating activities. Oncogene. 3:1988;105-112.
11. Bligh E.G., Dyer W.F. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
12. Touchstone J.C., Chen J.C., Beaver K.M. Improved separation of phospholipids by thin layer chromatography. Lipids. 15:1980;61-62.
13. Preiss J., Loomis C.R., Bishop W.R., Stein R., Niedel J.E., Bell R.M. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261:1986;8597-8600.
14. W.H. Evans, Organelles and membranes of animal cells, in: Biological Membranes: A Practical Approach, IRL Press, Washington DC, 1987, pp. 1-35.
15. Homma Y., Imaki J., Nakanishi O., Takenawa T. Isolation and characterization of two different forms of phospholipase C from rat brain. J. Biol. Chem. 263:1988;6592-6598.
16. Yavin E. Regulation of phospholipid metabolism in differentiating cells from rat brain cerebral hemispheres in culture. J. Biol. Chem. 251:1976;1392-1397.
17. Brown A., Gutowski S., Moomaw C., Slaughter C., Sternwels P. ADP-ribosylation factor, a small GTP-dependent regulatory protein stimulates phospholipase D activity. Cell. 75:1993;1137-1144.
18. Hubsher G., Clark B. Metabolism of phospholipids. Isolation and properties of phosphatidic acid from mammalian liver. Biochim. Biophys. Acta. 41:1960;45-54.
19. Lowry O.H., Rozenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
20. Ratnam S., Kent C. Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines. Arch. Biochem. Biophys. 323:1995;313-322.
21. Porter T.J., Kent C. Purification and charachterization of choline/ethanolamine kinase from rat liver. J. Biol. Chem. 265:1990;414-422.
22. English D., Cui Y., Siddigui R.A. Messenger functions of phosphatidic acid. Chem. Phys. Lip. 80:1996;117-132.
23. Del Peso L., Hernandez R., Esteve P., Lacal J.C. Activation of phospholipase D by ras-proteins is independent of protein kinase C. J. Cell. Biochem. 61:1996;599-608.
24. Cuadrado A., Carnero A., Dolfi F., Jimenez B., Lacal J.C. Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene. 8:1993;2959-2968.
25. Kiss Z., Crilly K. Ha-ras stimulates uptake and phosphorylation of ethanolamine: inhibition by wortmannin. FEBS Lett. 357:1995;279-282.
26. Teegarden D., Taparowsky E., Kent C. Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene. J. Biol. Chem. 265:1990;6042-6047.
27. Exton J.H. New developments in phospholipase D. J. Biol. Chem. 272:1997;15579-15582.
28. Lacal J.C. Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism. Mol. Cell. Biol. 10:1990;333-340.
29. Pettitt T., Martin A., Horton T., Liossis C., Lord J., Wakelam M. Diacylglycerol and phosphatidate generated by phospholipases C and D respectively, have distinct fatty acid compositions and functions. J. Biol. Chem. 272:1997;17354-17359.