Studies on the spasmolytic and uterine relaxant actions of N-ethyl and N-benzyl-1,2-diphenyl ethanolamines: Elucidation of the mechanisms of action

Pharmacological Research

Volumn 39, Issue 6, 1999, Pages 463-470

  Bakheet, Dana M ^a   El Tahir, K E H ^a   Al Sayed, M I ^a   El Obeid, H A ^a   Al Rashood, K A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Ca2+ channels; Intestine; N ethyl and N benzyl 1,2 diphenyl ethanolamine; Oxytocics; Uterus

Indexed keywords

ACETYLCHOLINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHLORIDE; ETHANOLAMINE DERIVATIVE; HISTAMINE; HISTAMINE H2 RECEPTOR ANTAGONIST; NICOTINE; OXYTOCIC AGENT; OXYTOCIN; POTASSIUM ION; PROSTAGLANDIN E2; SEROTONIN; SPASMOLYTIC AGENT;

ANIMAL TISSUE; ARTICLE; COLIC; CONTROLLED STUDY; DEPOLARIZATION; DYSMENORRHEA; FEMALE; GUINEA PIG; ILEUM; INTESTINE MUSCLE; IRRITABLE COLON; JEJUNUM; MALE; NONHUMAN; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; RABBIT; RAT; SMOOTH MUSCLE CONTRACTION; UTERUS RELAXATION;

EID: 0033003160     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0459     Document Type: Article

References (29)

1. 2+antagonists (Iproveratril, D600 and prenylamine). Pflugers Arch Ges Physiol. 307:1969;26-32.
2. 2+) and their antagonism in various body functions. Saudi Pharm J. 1997;139-155.
3. Schwartz A. Molecular and cellular aspects of calcium channel antagonism. Am J Cardiol. 1992.
4. Sigurdson W, Ruknudin A, Sachs F. Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels. Am J Physiol. 1992;1110-1115.
5. Mendelowitz D, Reynolds P G, Andresen M C. Heterogeneous functional expression of calcium channels at sensory and synaptic regions in nodose neurons. J Neurophysiol. 1995;872-875.
6. Mc Cleskey E W. Calcium channels: cellular roles and molecular mechanisms. Curr Opin Neurobiol. 1994;304-312.
7. Honer-jager P, Seibel K. Pharmacodynamics of nilvadipine, a new dihydropyridine-type calcium antagonism-162B. J Cardiovasc Pharmacol. 1992.
8. N-alkyl-1,2- diphenylethanolamines. Pharm Res. 4:1987;166-170.
9. EL Tahir K EH, EL-Obeid H A, AL-Rashood K A, Madani A AE, Ageel A M. The an tiarrhythmic activity of N -alkyl-1,2-diphenylethanolamines. Pharm Res. 6:1989;252-254.
10. El Tahir, K, EH, El-Naser, M, AS, Ageel, A, M, El-Obeid, H, A, Al-Rashood, K, A, The c ardiovascular depressant effects of N -methyl- and N -isobutyl-1,2-diphenylethanolamines: elucidation of the mechanisms of action, Arch Inter Pharmacodyn Ther, 309, 88, 102.
11. El Tahir, K, EH, El Naser, M, AS, Ageel, A, M, El Obeid, H, A, Al-Rashood, K, A, Effects of N -methyl- and N -isobutyl-1,2-diphenyl ethanolamines on the spontaneous and evoked contractions in the rat isolated uterus, Gen Pharmacol, 22, 685, 90.
12. El Tahir K EH, Ageel A M, Mekkawi A G, Bashir A K, Mossa J S, Khaled S A. Pharmacological actions of the leaves of Solenostemma argel (Hayne): spasmolytic and uterine relaxant activities. Int J Crude Drug Res. 25:1987;57-63.
13. Goldberg L. Studies on local anaesthetics. Acta Physiol Scand. 18:1949;1-18.
14. Bolli P, Wood A J, Simpson F O. Effects of prazosin in patients with hypertension. Clin Pharmacol Ther. 20:1976;138-218.
15. Benedict R L, Leighton S W, Janice L C. Antiarrhythmic effects of β-adrenergic blocking agents. Ann NY Acad Sci. 1967;945-951.
16. Abe Y. Effects of changing the ionic environment on passive and active membrane properties of pregnant rat uterus. J Physiol. 214:1971;173-190.
17. Tomita J, Watanabe H. Factors controlling myogenic activity in smooth muscle. Philos Trans R Soc London Ser B. 265:1973;73-85.
18. Kao C Y, Mc Cullough J R. Ionic currents in the uterine smooth muscle. J Physiol. 246:1975;1-36.
19. Bolton T B. Mechanisms of action of transmitters and other substances on smooth muscles. Physiol Rev. 59:1979;606-717.
20. 2+and its related bivalent cations in the KCl-depolarized rat uterus. Jpn J Pharmacol. 28:1978;681-692.
21. Mangel A W, Nelson D O, Rabovsky J L, Prosser C L, Connor J A. Depolarization-induced contractile activity of smooth muscle in calcium-free solution. Am J Physiol. 1982.
22. Lino M. Calcium release mechanisms in smooth muscles. Jpn J Pharmacol. 1990;345-354.
23. 2+in neurons. Neuroscience. 1992;251-273.
24. 3H]ryanodine-binding sites in smooth muscles, Biochem J, 15(290(Pt1)):, 259, 66.
25. 2+release cha nnels in smooth muscle and isolated membranes, Biol Signals, 2(5):, 284, 92.
26. Ogawa Y. Role of ryanodine receptors. Crit Rev Biochem Mol Biol. 1994;229-274.
27. Somlyo A P, Himpens B. Cell calcium and its regulation in smooth muscles. FASEB J. 1989;2266-2276.
28. Sperelakis N. Regulation of calcium slow channels of heart by cyclic nucleotides and effects of ischemia. Adv Pharmacol. 31:1994;1-24.
29. Milovanovic S R, Ognjanovic J, Varagic V M, Boskovic B. Effect of nicardipine on the isolated uterus and other smooth muscles of the rat. Arch Int Pharmacodyn Ther. 295:1988;291-304.