Disruption of substrate binding site in E. coli RNA polymerase by lethal alanine substitutions in carboxy terminal domain of the β subunit

FEBS Letters

Volumn 444, Issue 2-3, 1999, Pages 189-194

  Polyakov, Andrey ^a,b   Nikiforov, Vadim ^b   Goldfarb, Alex ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

RNA polymerase; RNAP, RNA polymerase; Site directed mutagenesis; Substrate binding center

Indexed keywords

ALANINE; RNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GENE DISRUPTION; LETHAL MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

BINDING SITES; CONSERVED SEQUENCE; DNA; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; MUTAGENESIS, SITE-DIRECTED; OLIGORIBONUCLEOTIDES; PROTEIN BINDING; TRANSCRIPTION, GENETIC;

EID: 0033002288     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)00060-5     Document Type: Article

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