Design and characterization of a surfactant-enriched tablet formulation for oral delivery of a poorly water-soluble immunosuppressive agent

International Journal of Pharmaceutics

Volumn 182, Issue 2, 1999, Pages 173-186

  Ruddy, Stephen B ^a   Matuszewska, Bozena K ^a   Grim, Yvetta A ^a   Ostovic, Drazen ^a   Storey, David E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Immunosuppressive agent; Micellar solubilization; Poorly water soluble drug; Sodium lauryl sulfate; Surfactant; Tablet formulation

Indexed keywords

DODECYL SULFATE SODIUM; IMMUNOSUPPRESSIVE AGENT; L 733725; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; MICELLE; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; PRIORITY JOURNAL; TABLET; THEORY;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; IMIDAZOLES; IMMUNOSUPPRESSIVE AGENTS; PARTICLE SIZE; SODIUM DODECYL SULFATE; SOLUBILITY; SURFACE-ACTIVE AGENTS; TABLETS; TACROLIMUS;

EID: 0033000119     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00056-3     Document Type: Article

References (19)

1. Ammar H.O., El-Nahhas S.A. Solubilization of bromhexine hydrochloride by non-ionic surfactants. Pharmazie. 49:1994;583-585.
2. Ammar H.O., Omar S.M. Solubilization of carbamazepine by non-ionic surfactants. Pharmazie. 49:1994;746-748.
3. Attwood, D., Florence, A.T., 1983. Pharmaceutical aspects of solubilization. In: Surfactant Systems, Chapman and Hall, New York, pp. 293-387.
4. Fahelelbom K.M.S., Timoney R.F., Corrigan O.I. Micellar solubilization of clofazimine analogues in aqueous solutions of ionic and nonionic surfactants. Pharm. Res. 10:1993;631-634.
5. Florence, A.T., 1982. Surfactant solutions. In: Yalkowsky S.H. (Ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, pp. 221-258.
6. Goulet M.T., McAlpine S.R., Staruch M.J., Koprak S., Dumont F.J., Cryan J.G., Wiederrecht G.J., Rosa R., Wilusz M.B., Peterson L.B., Wyvratt M.J., Parsons W.H. C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential. Bioorg. Med. Chem. Lett. 8:1998;2253-2258.
7. Korsmeyer R.W., Gurny R., Doelker E., Buri P., Peppas N.A. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15:1983;25-35.
8. Lerk P.C., Sucker H. Application of sucrose laurate, a new pharmaceutical excipient in peroral formulations of cyclosporine-A. Int. J. Pharm. 92:1993;197-202.
9. McBain, M.E.L., Hutchinson, E. 1955. Solubilization and Related Phenomena, Academic Press, New York.
10. Moore J.W., Flanner H.H. Mathematical comparison of dissolution profiles. Pharm. Tech. 20:1996;64-74.
11. Peppas N.A. A model of dissolution-controlled solute release from porous drug delivery polymeric systems. J. Biomed. Mater. Res. 17:1983;1079-1087.
12. Peppas N.A. Analysis of Fickian and non-Fickian drug release from polymers. Acta Helv. 60:1985;110-111.
13. Ragnarsson, G., 1996. Force-displacement and network measurements. In: Alderborn, G., Nystrom, C. (Ed.), Pharmaceutical Powder Compaction Technology, Marcel Dekker, New York, pp. 77-97.
14. Rieger, M.M., 1996. Surfactants. In: Lieberman, H.A., Rieger, M.M., Banker, G.S. (Ed.), Pharmaceutical Dosage Forms: Disperse Systems, Vol. 1, 2nd Ed., Marcel Dekker, New York, pp. 211-286.
15. Ritger P.L., Peppas N.A. A simple equation for description of solute release. I. Fickian and non-Fickian release from non-swellable devices in form of slabs, spheres, cylinders or discs. J. Controlled Release. 5:1987;23-36.
16. Ritger P.L., Peppas N.A. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J. Controlled Release. 5:1987;37-42.
17. Rosen, M.J., 1989. Solubilization by solutions of surfactants: micellar catalysis. In: Surfactants and Interfacial Phenomema, 2nd Ed. Wiley, New York, pp. 170-206.
18. Safety Assessment Expert Panel, 1983. Final report on the safety assessment of sodium lauryl sulfate and ammonium lauryl sulfate. J. Am. Coll. Toxicol. 2, 127-181.
19. Sjoblom, L., 1958. Solubility of 17α-ethynyl testosterone in aqueous solutions of some association colloids. Acta Acad. Aboensis. Math. Phys. 21.