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Volumn 270, Issue 3 33-3, 1996, Pages

Hep G2 cells: A model for studies on regulation of human cholesterol 7α-hydroxylase at the molecular level

Author keywords

Bile acid; Liver

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; DACTINOMYCIN; DEOXYCHOLIC ACID; GLYCOCHENODEOXYCHOLIC ACID; MESSENGER RNA; POLYADENYLATED RNA;

EID: 0029862934     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.3.g401     Document Type: Article
Times cited : (37)

References (49)
  • 1
    • 0026007201 scopus 로고
    • Bile acid synthesis in cultured human hepatoblastoma cells
    • Axelson, M., B. Mörk, and G. T. Everson. Bile acid synthesis in cultured human hepatoblastoma cells. J. Biol. Chem. 266: 17770-17777, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 17770-17777
    • Axelson, M.1    Mörk, B.2    Everson, G.T.3
  • 2
    • 0025747508 scopus 로고
    • Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo
    • Bertolotti, M., N. Abate, P. Loria, M. Dilengite, F. Carubbi, A. Pinetti, A. Digrisolo, and N. Carulli. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo. Hepatology 14: 830-837, 1991.
    • (1991) Hepatology , vol.14 , pp. 830-837
    • Bertolotti, M.1    Abate, N.2    Loria, P.3    Dilengite, M.4    Carubbi, F.5    Pinetti, A.6    Digrisolo, A.7    Carulli, N.8
  • 3
    • 77956841570 scopus 로고
    • Mechanism of bile acid biosynthesis in mammalian liver
    • edited by H. Danielsson and J. Sjovall. New York: Elsevier
    • Bjorkhem, I. Mechanism of bile acid biosynthesis in mammalian liver. In: Sterols and Bile Acids, edited by H. Danielsson and J. Sjovall. New York: Elsevier, 1985, p. 231-278.
    • (1985) Sterols and Bile Acids , pp. 231-278
    • Bjorkhem, I.1
  • 4
    • 0020399642 scopus 로고
    • Hydroxylations in biosynthesis of bile acids
    • Bostrom, H., and K. Wikvall. Hydroxylations in biosynthesis of bile acids. J. Biol. Chem. 257: 11755-11759, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 11755-11759
    • Bostrom, H.1    Wikvall, K.2
  • 6
    • 0028278187 scopus 로고
    • Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter
    • Chiang, J. Y. L., and D. Stroup. Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter. J. Biol. Chem. 269: 17502-17507, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17502-17507
    • Chiang, J.Y.L.1    Stroup, D.2
  • 7
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin, J. M., A. B. Przybyla, R. J. MacDonald, and W. J. Rutter. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294-5299, 1979.
    • (1979) Biochemistry , vol.18 , pp. 5294-5299
    • Chirgwin, J.M.1    Przybyla, A.B.2    MacDonald, R.J.3    Rutter, W.J.4
  • 8
    • 0020679009 scopus 로고
    • The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors
    • Ciechanover, A., A. L. Schwartz, and H. F. Lodish. The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell 32: 267-275, 1983.
    • (1983) Cell , vol.32 , pp. 267-275
    • Ciechanover, A.1    Schwartz, A.L.2    Lodish, H.F.3
  • 9
    • 0028007161 scopus 로고
    • Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells
    • Cooper, A. D., W. Y. Craig, T. Taniguchi, and G. T. Everson. Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells. Hepatology 20: 1522-1531, 1994.
    • (1994) Hepatology , vol.20 , pp. 1522-1531
    • Cooper, A.D.1    Craig, W.Y.2    Taniguchi, T.3    Everson, G.T.4
  • 10
    • 0027448743 scopus 로고
    • Genornic cloning, sequencing, and analysis of the hamster cholesterol 7α-hydroxylase gene (CYP7)
    • Crestani, M., G. Galli, and J. Y. L. Chiang. Genornic cloning, sequencing, and analysis of the hamster cholesterol 7α-hydroxylase gene (CYP7). Arch. Biochem. Biophys. 306: 451-460, 1994.
    • (1994) Arch. Biochem. Biophys. , vol.306 , pp. 451-460
    • Crestani, M.1    Galli, G.2    Chiang, J.Y.L.3
  • 11
    • 0000415004 scopus 로고
    • Preparation and analysis of RNA from eukaryotic cells
    • edited by L. G. Davis. New York: Elsevier
    • Davis, L. G., M. D. Dibner, and J. F. Battey. Preparation and analysis of RNA from eukaryotic cells. In: Basic Methods in Molecular Biology, edited by L. G. Davis. New York: Elsevier, 1986, p. 129-156.
    • (1986) Basic Methods in Molecular Biology , pp. 129-156
    • Davis, L.G.1    Dibner, M.D.2    Battey, J.F.3
  • 12
    • 0022544210 scopus 로고
    • Parameters of cholesterol metabolism in the human hepatoma cell line, Hep G2
    • Erickson, S. K., and P. E. Fielding. Parameters of cholesterol metabolism in the human hepatoma cell line, Hep G2. J. Lipid Res. 27: 875-883, 1986.
    • (1986) J. Lipid Res. , vol.27 , pp. 875-883
    • Erickson, S.K.1    Fielding, P.E.2
  • 13
    • 0023097925 scopus 로고
    • Steady-state kinetics of serum bile acids in healthy human subjects: Single and dual isotope techniques using stable isotopes and mass spectrometry
    • Everson, G. T. Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry. J. Lipid Res. 28: 238-252, 1987.
    • (1987) J. Lipid Res. , vol.28 , pp. 238-252
    • Everson, G.T.1
  • 14
    • 0023032022 scopus 로고
    • HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation
    • Everson, G. T., and M. A. Polokoff. HepG2. A human hepatoblastoma cell line exhibiting defects in bile acid synthesis and conjugation. J. Biol. Chem. 261: 2197-2201, 1986.
    • (1986) J. Biol. Chem. , vol.261 , pp. 2197-2201
    • Everson, G.T.1    Polokoff, M.A.2
  • 15
    • 0027138745 scopus 로고
    • Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activites in the oxidation of the C27 steroid side chain in bile acid formation
    • Farrants, A. Ö., A. Nilsson, and J. I. Pedersen. Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activites in the oxidation of the C27 steroid side chain in bile acid formation. J. Lipid Res. 34: 2041-2050, 1994.
    • (1994) J. Lipid Res. , vol.34 , pp. 2041-2050
    • Farrants, A.Ö.1    Nilsson, A.2    Pedersen, J.I.3
  • 17
    • 0020503225 scopus 로고
    • Proteolytic processing of human preproapolipoprotein A-I. A proposed defect in the conversion of pro A-I to A-I in Tangier's disease
    • Gordon, J. L., S. R. Sims, S. R. Lentz, C. Edelstem, A. Scanu, and A. W. Strauss. Proteolytic processing of human preproapolipoprotein A-I. A proposed defect in the conversion of pro A-I to A-I in Tangier's disease. J. Biol. Chem. 258: 4037-4044, 1983.
    • (1983) J. Biol. Chem. , vol.258 , pp. 4037-4044
    • Gordon, J.L.1    Sims, S.R.2    Lentz, S.R.3    Edelstem, C.4    Scanu, A.5    Strauss, A.W.6
  • 18
    • 0024373642 scopus 로고
    • Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and activities of enzymes regulating cholesterol and bile acid synthesis in the rat
    • Heuman, D. M., P. B. Hylemon, and Z. R. Vlahcevic. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J. Lipid Res. 30: 1161-1171, 1989.
    • (1989) J. Lipid Res. , vol.30 , pp. 1161-1171
    • Heuman, D.M.1    Hylemon, P.B.2    Vlahcevic, Z.R.3
  • 19
    • 0023805311 scopus 로고
    • Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat
    • Heuman, D. M., Z. R. Vlahcevic, M. L. Bailey, and P. B. Hylemon. Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat. Hepatology 8: 892-897, 1988.
    • (1988) Hepatology , vol.8 , pp. 892-897
    • Heuman, D.M.1    Vlahcevic, Z.R.2    Bailey, M.L.3    Hylemon, P.B.4
  • 21
    • 0027242111 scopus 로고
    • Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat
    • Hoekman, M. F. M., J. M. J. Rientjes, J. Twisk, R. J. Planta, H. M. G. Princen, and W. H. Mager. Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat. Gene 180: 217-223, 1993.
    • (1993) Gene , vol.180 , pp. 217-223
    • Hoekman, M.F.M.1    Rientjes, J.M.J.2    Twisk, J.3    Planta, R.J.4    Princen, H.M.G.5    Mager, W.H.6
  • 22
    • 0021932543 scopus 로고
    • Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism
    • Hylemon, P. B., E. C. Gurley, W. M. Kubaska, T. R. Whitehead, P. S. Guzelian, and Z. R. Vlahcevic. Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism. J. Biol. Chem. 260: 1015-1019, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 1015-1019
    • Hylemon, P.B.1    Gurley, E.C.2    Kubaska, W.M.3    Whitehead, T.R.4    Guzelian, P.S.5    Vlahcevic, Z.R.6
  • 23
    • 0026794030 scopus 로고
    • Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures
    • Hylemon, P. B., E. C. Gurley, R. T. Stravitz, J. S. Litz, W. M. Pandak, J. Y. L. Chiang, and Z. R. Vlahcevic. Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J. Biol. Chem. 267: 16866-16871, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16866-16871
    • Hylemon, P.B.1    Gurley, E.C.2    Stravitz, R.T.3    Litz, J.S.4    Pandak, W.M.5    Chiang, J.Y.L.6    Vlahcevic, Z.R.7
  • 24
    • 0024414265 scopus 로고
    • Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- And 7α-hydroxyeholesterol
    • Javitt, N. B., and K. Budai. Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7α-hydroxyeholesterol. Biochem. J. 262: 989-992, 1989.
    • (1989) Biochem. J. , vol.262 , pp. 989-992
    • Javitt, N.B.1    Budai, K.2
  • 26
    • 0025269939 scopus 로고
    • Cloning and regulation of cholesterol 7α-hydroxylase, the rate limiting enzyme in bile acid biosynthesis
    • Jelinek, D. F., S. Andersson, C. R. Slaughter, and D. W. Russell. Cloning and regulation of cholesterol 7α-hydroxylase, the rate limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265: 8190-8197, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8190-8197
    • Jelinek, D.F.1    Andersson, S.2    Slaughter, C.R.3    Russell, D.W.4
  • 27
    • 0025984495 scopus 로고
    • Effects of actinomycin D and cycloheximide on transcript levels of IGF-I, actin, and albumin in hepatocyte primary cultures treated with growth hormone and insulin
    • Johnson, T., J. Trojan, S. Rudin, B. Blossey, and J. Ilan. Effects of actinomycin D and cycloheximide on transcript levels of IGF-I, actin, and albumin in hepatocyte primary cultures treated with growth hormone and insulin. Mol. Reprod. Dev. 30: 95-99, 1991.
    • (1991) Mol. Reprod. Dev. , vol.30 , pp. 95-99
    • Johnson, T.1    Trojan, J.2    Rudin, S.3    Blossey, B.4    Ilan, J.5
  • 28
    • 0026755177 scopus 로고
    • Polymorphisms of human cholesterol 7α-hydroxylase
    • Karam, W. G., and J. Y. L. Chiang. Polymorphisms of human cholesterol 7α-hydroxylase. Biochem. Biophys. Res. Commun. 185: 588-595, 1992.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 588-595
    • Karam, W.G.1    Chiang, J.Y.L.2
  • 29
    • 0028076350 scopus 로고
    • Bile acid synthesis in Hep G2 cells: Effect of cyclosporin
    • Levy, J., K. Budai, and N. B. Javitt. Bile acid synthesis in Hep G2 cells: effect of cyclosporin. J. Lipid Res. 35: 1795-1800, 1994.
    • (1994) J. Lipid Res. , vol.35 , pp. 1795-1800
    • Levy, J.1    Budai, K.2    Javitt, N.B.3
  • 30
    • 0025353861 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA
    • Li, Y. C., D. P. Wang, and J. Y. L. Chiang. Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA. J. Biol. Chem. 265. 12012-12019, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 12012-12019
    • Li, Y.C.1    Wang, D.P.2    Chiang, J.Y.L.3
  • 31
    • 0027207770 scopus 로고
    • Tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on Hep G2 cells
    • Liao, W., and C. H. Floren. Tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on Hep G2 cells Hepatology 17: 898-907, 1993.
    • (1993) Hepatology , vol.17 , pp. 898-907
    • Liao, W.1    Floren, C.H.2
  • 32
    • 0027523427 scopus 로고
    • Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: Evidence for two different enzymes
    • Martin, K. O., K. Budai, and N. B. Javitt. Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J. Lipid Res. 34: 581-588, 1993.
    • (1993) J. Lipid Res. , vol.34 , pp. 581-588
    • Martin, K.O.1    Budai, K.2    Javitt, N.B.3
  • 33
    • 0025894157 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase nxRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat
    • Pandak, W. M., Y. C. Li, J. Y. L. Chiang, E. J. Studer, E. C. Gurley, D. M. Heuman, Z. R. Vlahcevic, and P. B. Hylemon. Regulation of cholesterol 7α-hydroxylase nxRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. J. Biol. Chem. 266: 3416-3421, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3416-3421
    • Pandak, W.M.1    Li, Y.C.2    Chiang, J.Y.L.3    Studer, E.J.4    Gurley, E.C.5    Heuman, D.M.6    Vlahcevic, Z.R.7    Hylemon, P.B.8
  • 34
    • 0027433258 scopus 로고
    • Bile acid excretion and cholesterol 7α-hydroxylase expression in hypercholesterolemia-resistant rabbits
    • Poorman, J. A., R. A. Buck, S. A. Smith, M. L. Ovcrturf, and D. S. Loose-Mitchell. Bile acid excretion and cholesterol 7α-hydroxylase expression in hypercholesterolemia-resistant rabbits. J. Lipid Res. 34: 1675-1685, 1993.
    • (1993) J. Lipid Res. , vol.34 , pp. 1675-1685
    • Poorman, J.A.1    Buck, R.A.2    Smith, S.A.3    Ovcrturf, M.L.4    Loose-Mitchell, D.S.5
  • 35
    • 0028300020 scopus 로고
    • Cholesterol and bile acids regulate cholesterol 7α-hydroxylase expression at the transcriptional level in culture and in transgenic mice
    • Ramirez, M. I., D. Karaoglu, D. Haro, C. Barillas, R. Bashirzadeh, and G. Gil. Cholesterol and bile acids regulate cholesterol 7α-hydroxylase expression at the transcriptional level in culture and in transgenic mice. Mol. Cell Biol. 14: 2809-2821, 1994.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 2809-2821
    • Ramirez, M.I.1    Karaoglu, D.2    Haro, D.3    Barillas, C.4    Bashirzadeh, R.5    Gil, G.6
  • 36
    • 0019835776 scopus 로고
    • Lipoprotein apolipoprotein synthesis by human hepatoma cell in culture
    • Rash, J. M., G. H. Rothblat, and C. E. Sparks. Lipoprotein apolipoprotein synthesis by human hepatoma cell in culture. Biochim. Biophys. Acta 666: 294-298, 1981.
    • (1981) Biochim. Biophys. Acta , vol.666 , pp. 294-298
    • Rash, J.M.1    Rothblat, G.H.2    Sparks, C.E.3
  • 37
    • 0024408133 scopus 로고
    • Bile acid synthesis in humans: Regulation of hepatic microsomal cholesterol 7α-hydroxylase activity
    • Réihner, E., I. Björkhem, B. Angelin, S. Ewerth, and K. Einarsson. Bile acid synthesis in humans: regulation of hepatic microsomal cholesterol 7α-hydroxylase activity. Gastroenterology 97: 1498-1505, 1989.
    • (1989) Gastroenterology , vol.97 , pp. 1498-1505
    • Réihner, E.1    Björkhem, I.2    Angelin, B.3    Ewerth, S.4    Einarsson, K.5
  • 38
    • 0028338785 scopus 로고
    • Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys
    • Rudel, L., C. Deckelman, M. Wilson, M. Scobey, and R. Anderson. Dietary cholesterol and downregulation of cholesterol 7α-hydroxylase and cholesterol absorption in African green monkeys. J. Clin. Invest. 93: 2463-2472, 1994.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2463-2472
    • Rudel, L.1    Deckelman, C.2    Wilson, M.3    Scobey, M.4    Anderson, R.5
  • 39
    • 0019932716 scopus 로고
    • A rapid method for the quantitative extraction of bile acids and their conjugates from seruin using commercially available reverse-phase octadecylsilane bonded silica cartridges
    • Setchell, K. D. R., and J. Worthington. A rapid method for the quantitative extraction of bile acids and their conjugates from seruin using commercially available reverse-phase octadecylsilane bonded silica cartridges. Clin. Chim. Acta 125: 135-144, 1982.
    • (1982) Clin. Chim. Acta , vol.125 , pp. 135-144
    • Setchell, K.D.R.1    Worthington, J.2
  • 40
    • 0014841283 scopus 로고
    • Biochemical site of regulation of bile acid biosynthesis in the rat
    • Shefer, S., S. Hauser, I. Bekersky, and E. H. Mosbach. Biochemical site of regulation of bile acid biosynthesis in the rat. J. Lipid Res. 11: 404-411, 1970.
    • (1970) J. Lipid Res. , vol.11 , pp. 404-411
    • Shefer, S.1    Hauser, S.2    Bekersky, I.3    Mosbach, E.H.4
  • 42
    • 0028979936 scopus 로고
    • Repression of cholesterol 7α-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes
    • Stravitz, R. T., Z. R. Vlahcevic, E. C. Gurley, and P. B. Hylemon. Repression of cholesterol 7α-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes. J. Lipid Res. 36: 1359-1369, 1995.
    • (1995) J. Lipid Res. , vol.36 , pp. 1359-1369
    • Stravitz, R.T.1    Vlahcevic, Z.R.2    Gurley, E.C.3    Hylemon, P.B.4
  • 43
    • 0020858163 scopus 로고
    • Intracellular bile acid transport in rat liver as visualized by electron microscope autoradiography using a bile acid analogue
    • Gastrointest. Liver Physiol. 8
    • Suchy, F. J., W. F. Balistreri, J. Hung, P. Miller, and S. A. Garfield. Intracellular bile acid transport in rat liver as visualized by electron microscope autoradiography using a bile acid analogue. Am. J. Physiol. 245 (Gastrointest. Liver Physiol. 8): G681-G689, 1983.
    • (1983) Am. J. Physiol. , vol.245
    • Suchy, F.J.1    Balistreri, W.F.2    Hung, J.3    Miller, P.4    Garfield, S.A.5
  • 44
    • 0022003749 scopus 로고
    • Effects of estrogen on apolipoprotein secretion by the human hepatocellular cell line, Hep-G2
    • Tam, S. P., T. K. Archer, and R. G. Deely. Effects of estrogen on apolipoprotein secretion by the human hepatocellular cell line, Hep-G2. J. Biol. Chem. 260: 1670-1675, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 1670-1675
    • Tam, S.P.1    Archer, T.K.2    Deely, R.G.3
  • 45
    • 0028233386 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase gene expression in Hep-G2 cells
    • Taniguchi, T., J. Chen, and A. D. Cooper. Regulation of cholesterol 7α-hydroxylase gene expression in Hep-G2 cells. J. Biol. Chem. 269: 10071-10078, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10071-10078
    • Taniguchi, T.1    Chen, J.2    Cooper, A.D.3
  • 46
    • 0019061278 scopus 로고
    • Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose
    • Thomas, P. S. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77: 5201-5205, 1980.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 5201-5205
    • Thomas, P.S.1
  • 47
    • 0027457961 scopus 로고
    • Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes
    • Twisk, J., E. M. Lehmann, and H. M. G. Princen. Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes. Biochem. J. 290: 685-691, 1993.
    • (1993) Biochem. J. , vol.290 , pp. 685-691
    • Twisk, J.1    Lehmann, E.M.2    Princen, H.M.G.3
  • 48
    • 0021721178 scopus 로고
    • Activity and regulation of low density lipoprotein receptors in a human hepatoblastoma cell line
    • Wu, G. Y., C. H. Wu, V. A. Rifici, and R. J. Stockert. Activity and regulation of low density lipoprotein receptors in a human hepatoblastoma cell line. Hepatology 4: 1190-1194, 1984.
    • (1984) Hepatology , vol.4 , pp. 1190-1194
    • Wu, G.Y.1    Wu, C.H.2    Rifici, V.A.3    Stockert, R.J.4
  • 49
    • 0019813096 scopus 로고
    • Characterization of the major apolipoproteins secreted by two human hepatoma cell lines
    • Zannis, V. I., J. L. Breslow, T. R. San Giacomo, D. P. Aden, and B. B. Knowles. Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry 20: 7089-7096, 1981.
    • (1981) Biochemistry , vol.20 , pp. 7089-7096
    • Zannis, V.I.1    Breslow, J.L.2    San Giacomo, T.R.3    Aden, D.P.4    Knowles, B.B.5


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