On the scientific inference from clinical trials

Journal of Evaluation in Clinical Practice

Volumn 5, Issue 2, 1999, Pages 157-162

  Holmberg, L ^a   Baum, M ^b   Adami, H O ^c,d  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c KAROLINSKA INSTITUTE   (Sweden)

^d HARVARD CENTER FOR CANCER PREVENTION   (United States)

Author keywords

Evidence based medicine; Inference; Randomized controlled trials, knowledge

Indexed keywords

BIOSTATISTICS; CLINICAL MEDICINE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EVIDENCE BASED MEDICINE; LEARNING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STATISTICS;

EID: 0032999049     PISSN: 13561294     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2753.1999.00206.x     Document Type: Review

References (12)

1. Baum M. & Benson J.R. (1996) Current and future roles of adjuvant endocrine therapy in the management of early carcinoma of the breast. In: Adjuvant therapy of breast cancer V (Eds H. J. Senn, R. D. Gelber & A. Goldhirsch). Springer Verlag, Berlin, pp. 215-226.
2. Baum M., Chaplain M., Anderson A., Douek M. & dVaidya J.S. (1999) Does breast cancer exist in a state of chaos? European Journal of Cancer in press.
3. Early Breast Cancer Trialists Collaborative Group. (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351, 1451-1467.
4. Elwood M. (1998) Clinical appraisal of epidemiological studies and clinical trials, 2nd Edn. Oxford University Press, Oxford. p. 228.
5. Fisher B. (1980) Laboratory and clinical research in breast cancer - a personal adventure: the David A. Karnofsky memorial lecture. Cancer Research 40, 3863-3874.
6. Holmberg L. & Baum M. (1996) Work on your theories. Nature Medicine 2, 844-846.
7. Mant D. (1999) Can randomised trials inform clinical decisions about individual patients? Lancet 352, 743-746.
8. Popper K. (1992) The logic of scientific discovery. Routledge, London, pp. 2, 32, 107.
9. Popper K. (1994) Objective knowledge. An evolutionary approach. Oxford University Press, Oxford, pp. 24-25, 94.
10. Rothman K.J. & Greenland S. (1998) Modern Epidemiology 2nd Edn. Lippincott-Raven, Philadelphia. p. 113.
11. Sackett D.L., Richardson W.S., Rosenberg W. & Haynes R.B. (1997) Evidence Based Medicine. How to practice and teach EBM. Churchill-Livingstone, New York. p. 168.
12. Weiss N.S. (1996) Clinical Epidemiology: The study of the outcome of illness 2nd Edn. Oxford University Press, Oxford, p. 49.