Smooth pursuit eye movements in chronic schizophrenics and healthy volunteers using a quantitative objective measure for detecting saccadic intrusions

Human Psychopharmacology

Volumn 14, Issue 2, 1999, Pages 87-94

  King, D J ^a,b   Mills, P J ^a,b   Mannion, M F ^b   Green, J F ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Holywell Hospital   (Ireland)

Author keywords

Antipsychotics; Electro oculogram; Saccadic intrusions; Schizophrenia; Smooth pursuit eye movements (SPEM)

Indexed keywords

NEUROLEPTIC AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DYSKINESIA; ELECTROOCULOGRAM; EXTRAPYRAMIDAL SYMPTOM; EYE POSITION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SMOOTH PURSUIT EYE MOVEMENT; SYMPTOM; VELOCITY;

EID: 0032997246     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1077(199903)14:2<87::AID-HUP70>3.0.CO;2-E     Document Type: Article

References (51)

1. Abel, L. A. and Hertle, R. W. (1988). Effects of psychoactive drugs on ocular motor behaviour. In Neuropsychology of Eye Movements, Johnson, C. W. and Pirrozzolo, F. J. (Eds), Erlbaum, Hillsdale, N. J., pp. 81-114.
2. Andreasen, N. C. (1982). Negative symptoms in schizophrenia, and definition and reliability. Archives of General Psychiatry, 39, 784-788.
3. A. P. Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn revised. APA, Washington DC.
4. Bartfai, A., Levander, S. E., Nybäck, H., Berggren, B. M. and Schalling, D. (1985). Smooth pursuit eye tracking, neuropsychological test performance, and computed tomography in schizophrenia. Psychiatry Research, 15, 49-62.
5. Blackwood, D. H. R., Young, A. H., McQueen, J. K., Martin, M. J., Roxborough, H. M., Muir, W. J., St. Clair, D. M. and Kean, D. M. (1991). Magnetic resonance imaging in schizophrenia: altered brain morphology associated with P300 abnormalities and eye tracking dysfunction. Biological Psychiatry, 30, 753-769.
6. Cegalis, J. A. and Sweeney, J. A. (1979). Eye movements in schizophrenia: a quantitative analysis. Biological Psychiatry, 14, 13-26.
7. Cegalis, J. A. and Sweeney, J. A. (1981). The effect of attention on smooth pursuit eye movements of schizophrenics. Journal of Psychiatric Research, 16, 145-161.
8. Crawford, T. J., Haeger, B., Kennard, C., Reveley, M. A. and Henderson, L. (1995a). Saccadic abnormalities in psychotic patients. I. Neuroleptic-free psychotic patients. Psychological Medicine, 25, 461-471.
9. Crawford, T. J., Haeger, B., Kennard, C., Reveley, M. A. and Henderson, L. (1995b). Saccadic abnormalities in psychotic patients. II. The role of neuroleptic treatment. Psychological Medicine, 25, 473-483.
10. David, I. (1980). Disorders of smooth pursuit eye movements in schizophrenics and the effect of neuroleptics in therapeutics doses. Activitas Nervosa Superior, 22, 155-156.
11. Diefendorf, A. R. and Dodge, R. (1908). An experimental study of the ocular reactions of the insane from photographic records. Brain, 31, 451-489.
12. Friedman, L., Abel, L. A., Jesberger, J. A., Malki, A., and Meltzer, H. Y. (1992a). Saccadic intrusions into smooth pursuit in patients with schizophrenia or affective disorder and normal controls. Biological Psychiatry, 31, 1110-1118.
13. Friedman, L., Jesberger, J. A. and Meltzer, H. Y. (1992b). Effects of typical antipsychotic medications and clozapine on smooth pursuit performance in patients with schizophrenia. Psychiatry Research, 41, 25-36.
14. Friedman, L., Jesberger, J. A. and Meltzer, H. Y. (1991). A model of smooth pursuit performance illustrates the relationship between gain, catch-up saccade rate, and catch-up saccade amplitude in normal controls and patients with schizophrenia. Biological Psvchiatry, 30, 537-556.
15. Friedman, L., Jesberger, J. A., Siever, L. J., Thompson, P., Mohs, R. and Meltzer, H. Y. (1995a). Smooth pursuit performance in patients with affective disorders or schizophrenia and normal controls: analysis with specific oculomotor measures, RMS error and qualitative ratings. Psychological Medicine, 25, 387-403.
16. Friedman, L., Kenny, J. T., Jesberger, J. A., Choy, M. M. and Meltzer, H. Y. (1995b). Relationship between smooth pursuit eye-tracking and cognitive performance in schizophrenia. Biological Psychiatry, 37, 265-272.
17. Fukushima, J., Fukushima, K., Chiba, T., Tanaka, S., Yamashita, I. and Kato, M. (1988). Disturbances of voluntary control of saccadic eye movements in schizophrenia patients. Biological Psychiatry, 23, 670-677.
18. Fukushima, J., Fukushima, K., Miyasaka, K. and Yamashita, I. (1994). Voluntary control of saccadic eye movement in patients with frontal cortical lesions and parkinsonian patients in comparison with that in schizophrenics. Biological Psychiatry, 36, 21-30.
19. Fukushima, J., Fukushima, K., Morita, N. and Yamashita, I. (1990). Further analysis of the control of voluntary saccadic eye movements in schizophrenic patients. Biological Psychiatry, 28, 943-958.
20. Green, J. F. and King, D. J. (1998). The effects of chlorpromazine and lorazepam on abnormal antisaccade and no-saccade distractibility. Biological Psychiatry, 44, 709-715.
21. Griffiths, A. N., Marshall, R. W. and Richens, A. (1984). Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance. British Journal of Clinical Pharmacology, 18 (Suppl. 1), 73S-82S.
22. Guy, W. (Ed.) (1976). Abnormal involuntary movement scale. In ECDEU Assessment Manual for Psychopharmacology. US Department of Health, Education and Welfare, Washington D.C., pp. 534-537.
23. Holzman, P. S., Levy, D. L. and Proctor, L. R. (1976). Smooth pursuit eye movements, attention and schizophrenia. Archives of General Psychiatry, 33, 1415-1420.
24. Holzman, P. S., Proctor, L. R. and Hughes, D. W. (1973). Eye tracking patterns in schizophrenia. Science, 181, 179-181.
25. Holzman, P. S., Proctor, L. R., Levy, D. L., Yasillo, N. J., Meltzer, H. Y. and Hurt, S. W. (1974). Eye tracking dysfunctions in schizophrenic patients and their relatives. Archives of General Psychiatry, 31, 143-151.
26. Holzman, P. S., Solomon, C. M., Levin, S. and Waternaux, C. S. (1984). Pursuit eye movement dysfunctions in schizophrenia: family evidence for specificity. Archives of General Psychiatry, 41, 136-139.
27. Holzman, P. S., O'Brian, C. and Waternaux, C. (1991). Effects of lithium treatment on eye movements. Biological Psychiatry, 29, 1001-1015.
28. Hutton, S. B., Crawford, T. J., Puri, B. K., Duncan, L.-J., Chapman, M., Kennard, C., Barnes, T. R. E. and Joyce, E. M. (1998). Smooth pursuit and saccadic abnormalities in first-episode schizophrenia. Psychological Medicine, 28, 685-692.
29. Iacono, W. G. and Lykken, D. T. (1979). Eye tracking and psychopathology: new procedures applied to a sample of normal monozygotic twins. Archives of General Psychiatry, 36, 1361-1369.
30. Iacono, W. G., Peloquin, L. J., Lumry, A. E., Valentine, R. H. and Tuason, V. B. (1982). Eye tracking in patients with unipolar and bipolar affective disorders in remission. Journal of Abnormal Psychology, 91, 35-44.
31. Iacono, W. G., Tauson, W. B. and Johnson, R. A. (1981). Dissociation of smooth pursuit and saccadic eye tracking in remitted schizophrenics. Archives of General Psychiatry, 38, 991-996.
32. King, D. J. and Green, J. F. (1996). Medication and cognitive functioning in schizophrenia. In Schizophrenia: A Neuropsychological Perspective, Pantelis, C., Nelson, H. E. and Barnes, T. R. E. (Eds), John Wiley, Chichester, pp. 419-445.
33. Levin, S. (1984). Frontal lobe dysfunctions in schizophrenia - I. Eye movement impairments. Journal of Psychiatric Research, 18, 27-55.
34. Levin, S., Holzman, P. S., Rothenberg, S. J. and Lipton, R. B. (1981). Saccadic eye movements in psychotic patients. Psychiatry Research, 5, 47-58.
35. Levy, D. L., Lipton, R. B., Holzman, P. S. and Davis, J. M. (1983). Eye tracking dysfunction unrelated to clinical state and treatment with haloperidol. Biological Psychiatry, 18, 813-819.
36. Levy, D. L., Lipton, R. B., Yasillo, N. J., Peterson, J., Pandey, G. and Davis, J. M. (1984). Psychotropic drug effects on smooth pursuit eye movements: a summary of recent findings. In Theoretical and Applied Aspects of Eye Movement Research, Gale, A. G. and Johnston, F. (Eds), Elsevier Science, Amsterdam, pp. 497-505.
37. Lindsey, D. T., Holzman, P. S., Haberman, S. and Yasillo, N. J. (1978). Smooth pursuit eye movements, comparison of two measurement techniques for studying schizophrenia. Journal of Abnormal Psychology, 87, 491-496.
38. Lipton, R. B., Levy, D. L., Holzman, P. S. and Levin, S. (1983). Eye movement dysfunctions in psychiatric patients: a review. Schizophrenia Bulletin, 9, 13-32.
39. Lynch, G., King, D. J., Green, J. F., Byth, W. and Wilson-Davis, K. (1997). The effects of haloperidol on visual search, eye movements and psychomotor performance. Psychopharmacology, 133, 233-239.
40. Mannion, M. F., Lynch, G. and King, D. J. (1994). Precision of measures of saccadic eye movements and conventional psychomotor function tests. Human Psychopharmacology, 9, 37-41.
41. Matthysse, S., Holzman, P. S. and Lange, K. (1986). The genetic transmission of schizophrenia: application of Mendelian latent structure analysis to eye tracking dysfunctions in schizophrenia and affective disorder. Journal of Psychiatric Research, 20, 57-76.
42. Mirsky, A. F. and Kornetsky, C. (1964). On the dissimilar effects of drugs on the digit symbol substitution and continuous performance tests. A review and preliminary integration of behavioral and physiological evidence. Psychopharmacologia, 5, 161-177.
43. Overall, J. E. and Gorman, D. R. (1962). The Brief Psychiatric Rating Scale. Psychological Reports, 10, 99-112.
44. Scarone, S., Gambini, O., Hafele, E., Elllodi, L. and Smeraldi, E. (1987). Neurofunctional assessment of schizophrenia: a preliminary investigation of the presence of eye tracking (SPEMs) and quality extinction test (QET) abnormalities in a sample of schizophrenic patients. Biological Psychiatry, 24, 253-259.
45. Shagass, C., Roemer, R. A. and Amadeo, M. (1976). Eye-tracking performance and engagement of attention. Archives of General Psychiatry, 33, 121-125.
46. Sharpe, J. A., Morrow, M. J. and Johnston, J. L. (1989). Smooth pursuit: anatomy, physiology and disorders. Bulletin of the Society of Belgian Ophthalmology, 237, 113-144.
47. Siever, L. J., Coursey, R. D., Alterman, I. S., Buchsbaum, M. S. and Murphy, D. L. (1984). Impaired smooth pursuit eye movement: vulnerability marker for schizotypal personality disorder in a normal volunteer population. American Journal of Psychiatry, 141, 1560-1566.
48. Simpson, G. M. and Angus, J. W. S. (1970). A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica, Suppl. 212, 11-19.
49. Spohn, H. E., Coyne, L. and Spray, J. (1988). The effect of neuroleptics and tardive dyskinesia on smooth pursuit eye movement in chronic schizophrenics. Archives of General Psychiatry, 45, 833-840.
50. Thaker, G. K., Nguyen, J. A. and Tamminga, C. A. (1989). Increased saccadic distractibility in tardive dyskinesia: functional evidence for subcortical GABA dysfunction. Biological Psychiatry, 25, 49-59.
51. Van den Bosch, R. J., Rozendaal, N. and Mol, J. M. F. A. (1987). Symptom correlates of eye tracking dysfunction. Biological Psychiatry, 22, 919-921.