The effects of haloperidol on visual search, eye movements and psychomotor performance

Psychopharmacology

Volumn 133, Issue 3, 1997, Pages 233-239

  Lynch, G ^a   King, D J ^a,b   Green, J F ^a,b   Byth, W ^b   Wilson Davis, K ^b  

^a Holywell Hospital   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Haloperidol; Lorazepam; Psychomotor tests; Saccidic eye movements; Smooth pursuit eye movements; Visual search

Indexed keywords

HALOPERIDOL; LORAZEPAM; PLACEBO;

ADULT; AKATHISIA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DYSPHORIA; EYE MOVEMENT; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RATING SCALE; REACTION TIME; SACCADIC EYE MOVEMENT; SMOOTH PURSUIT EYE MOVEMENT;

ADOLESCENT; ADULT; ATTENTION; CROSS-OVER STUDIES; DOPAMINE ANTAGONISTS; EYE MOVEMENTS; GABA MODULATORS; HALOPERIDOL; HUMANS; LORAZEPAM; MALE; PSYCHOMOTOR PERFORMANCE; PURSUIT, SMOOTH; SACCADES; VISUAL PERCEPTION;

EID: 0030879846     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050396     Document Type: Article

References (28)

1. Anderson BG, Reker D, Cooper TB (1981) Prolonged adverse effects of haloperidol in normal subjects. N Engl J Med 305: 643-644
2. Bittencourt PRM, Wade P, Smith AT, Richens A (1983) Benzodiazepines impair smooth pursuit eye movements. Br J Clin Pharmacol 12:523-533
3. Broadbent DE (1984) Performance and its measurement. Br J Clin Pharmacol 18 [suppl 1]:5S-9S
4. Calvert J, Troscianko T (1992) The role of dopamine in visual attentional processes. J Psychopharmacol 6:103
5. Cave KR, Wolfe JM (1990) Modelling the role of parallel processing in visual search. Cogn Psychol 22:225-271
6. Green JF, McElholm A, King DJ (1996) A comparison of the sedative and amnestic effects of chlorpromazine and lorazepam. Psychopharmacology 128:67-73
7. Griffiths AN, Marshall RW, Richens A (1984) Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance. Br J Clin Pharmacol 18 [suppl 1]: 73S-82S
8. Harris JP, Calvert JE, Leendertz JA, Phillipson OT (1990) The influence of dopamine on spatial vision. Eye 4:806-812
9. Holzman PS, Levy DL, Uhlenhuth EH, Proctor LR, Freedman DX (1975) Smooth pursuit eye movements and diazepam, chlorpromazine and secobarbital. Psychopharmacologia 44: 111-115
10. James B, James NMcI (1973) Low dosage haloperidol and induced anxiety in normal volunteers. N Z Med J 78:210-212
11. King DJ (1993) Measures of neuroleptic effects on cognition and psychomotor performance in healthy volunteers. In: Hindmarch I, Stonier P (eds) Human Psychopharmacology. Wiley, Chichester, pp 195-209
12. King DJ (1994) Psychomotor impairment and cognitive disturbances induced by neuroleptics. Acta Psychiatr Scand 89 [suppl 380]:53-58
13. King DJ, Bell P (1990) Differential effects of temazepam and haloperidol on saccadic eye movements and psychomotor performance. Br J Clin Pharmacol 29:590P
14. King DJ, Henry G (1992) The effect of neuroleptics on cognitive and psychomotor function: a preliminary study in healthy volunteers. Br J Psychiatry 160:647-653
15. King DJ, Bell P, Best SJ, Mannion M (1990) A comparison of the effects of chlorpromazine and temazepam on saccadic eye movements and psychomotor performance. Br J Clin Pharmacol 30: 309P-310P
16. King DJ, Burke M, Lucas RA (1995) Antipsychotic drug-induced dysphoria. Br J Psychiatry 167:480-482
17. Kornetsky C, Humphries O, Evarts EV (1957) Comparison of psychological effects of certain centrally acting drugs in man. AMA Arch Neurol Psychiatr 77:138-324
18. Magliozzi JR, Gillespie H, Lombrozo L, Hollister LE (1985) Mood alteration following oral and intravenous haloperidol and relationship to drug concentration in normal subjects. J Clin Pharmacol 25:285-290
19. Magliozzi JR, Mungas D, Laubly JN, Blunden D (1989) Effect of haloperidol on a symbol digit substitution task in normal adult males. Neuropsychopharmacology 2:29-37
20. Mannion MF, Lynch G, King DJ (1994) Precision of measures of saccadic eye movements and conventional psychomotor function tests. In: Hindmarch I, Stonier P (eds) Human Psychopharmacology. Wiley, Chichester, pp 37-41
21. Norris H (1971) The action of sedatives on brainstem oculomotor systems in man. Neuropharmacology 10:181-191
22. Parrott AC, Hindmarch I (1975) Haloperidol and chlorpromazine comparative effects upon arousal and performance. IRCS Med Sci 3:562
23. Saletu B, Grünberger J, Linzmayar L, Dubini A (1983) Determination of pharmacodynamics of the new neuroleptic zetidoline by neuroendocrinologic, pharmaco-EEG and psychometric studies. Int J Clin Pharmacol Ther Toxicol 21: 489-495
24. Sireteanu R, Rettenbach R (1995) Perceptual learning in visual search: fast, enduring, but non-specific. Vision Res 35: 2037-2043
25. Tiplady B (1988) A continuous attention test for the assessment of the acute behavioural effects of drugs. Psychopharmacol Bull 24:213-216
26. Tiplady B (1992) Continuous attention: rationale and discriminant validation of a test designed for use in psychopharmacology. Behav Res Methods Instrum Comput 24:16-21
27. Treisman AM, Gelade G (1980) A feature-integration theory of attention. Cogn Psychol 12:97-136
28. Wechsler D (1958) The measurement and appraisal of human intelligence, 4th edn. Williams and Wilkins, Baltimore