Staphylococcus aureus small colony variants: Rate of selection and MIC values compared to wild-type strains, using ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin

Clinical Microbiology and Infection

Volumn 5, Issue 6, 1999, Pages 376-378

  Schmitz, Franz Josef ^a,b   Von Eiff, Christof ^c   Gondolf, Mechthild ^a   Fluit, Ad C ^b   Verhoef, Jan ^b   Peters, Georg ^c   Hadding, Ulrich ^a   Heinz, Hans Peter ^a   Jones, Mark E ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MUTATION; MINIMUM INHIBITORY CONCENTRATION; PHENOTYPE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0032996547     PISSN: 1198743X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-0691.1999.tb00158.x     Document Type: Article

References (10)

1. Barbour RGH. Small colony variants ('G' forms) produced by Staphylococcus pyogenes during the development of resistance to streptomycin. Aust J Exp Biol Med Sci 1950; 28: 415-20.
2. Wise RI, Spink WW. The influence of antibiotics on the origin of small colonies (G variants) of Micrococcus pyogenes var. aureus. J Clin Invest 1954; 33: 1611-12.
3. Acar JF, Goldstein FW, Lagrange P. Human infections caused by thiamine or menadione requiring Staphylococcus aureus. J Clin Microbiol 1978; 8: 142-7.
4. Proctor RA, van Langevelde P, Kristjansson M, Maslow JN, Arbeit RD. Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin Infect Dis 1995; 20: 95-102.
5. Proctor RA, Vesga, O, Otten MF, et al. Staphylococcus aureus small colony variants cause persistent and resistant infections. Chemotherapy 1996; 42(suppl 2): 47-52.
6. von Eiff C, Heilmann C, Proctor R, Woltz C, Peters G, Götz F. A site-directed Staphylococcus aureus hemB mutant is a small colony variant which persists intracellularly. J Bacteriol 1997; 179: 4706-12.
7. Mitsujama J, Yamada H, Maehana J, et al. Characteristics of quinolone-induced small colony variants in Staphylococcus aureus. J Antimicrob Chemother 1997; 39: 697-705.
8. von Eiff C, Bettin D, Proctor RA, et al. Recovery of small colony variants of Staphylococcus aureus following gentamicin bead placement for osteomyelitis. Clin Infect Dis 1997; 25: 1250-1.
9. Schmitz FJ, Hofmann B, Hansen B, et al. Relationship between ciprofloxacin, oftoxacin, levofloxacin, sparfloxacin and moxifloxacin MICs and with mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 1998; 41: 481-4.
10. Ferrero L, Cameron B, Crouzet J. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother 1995; 39: 1554-8.