Staphylococcus aureus small colony variants cause persistent and resistant infections

Chemotherapy

Volumn 42, Issue , 1996, Pages 47-52

  Proctor, R A ^a,b   Vesga, O V ^a,b   Otten, M F ^a,c   Koo, S P ^d   Yeaman, M R ^d   Sahl, H G ^e   Bayer, A S ^d  

^a Department of Medical Microbiology and Immunology ^*  (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e UNIVERSITY OF BONN   (Germany)

Author keywords

Antibiotic resistance; Auxotrophs; Electron transport; Small colony variants; Staphylococcus aureus

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; COAGULASE; CYTOCHROME; HEMIN; MENADIONE; MENAQUINONE; PROTAMINE; STAPHYLOCOCCUS ALPHA TOXIN;

ANTIBIOTIC RESISTANCE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIUM COLONY; CONFERENCE PAPER; HUMAN; NONHUMAN; PERSISTENT INFECTION; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY CHAIN; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

EID: 0029932670     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000239502     Document Type: Article

References (13)

1. Hamill RJ, Vann JM, Proctor RA: Phagocytosis of Staphylococcus aureus by cultured bovine endothelial cells: A model for postadhercnce events in endovascular infections. Infect Immun 1986;54:833-836.
2. Vann JM, Proctor RA: Cytotoxic effects of ingested Staphylococcus aureus on bovine endothelial cells: Role of 5, aureus a-hcmolysin. Mi-crob Pathog 1988;4:443-453.
3. Proctor RA: Microbial pathogenic factors: Small colony variants; in Bisno AL, Waldvogel FA (cds): Infections Associated with Indwelling Medical Devices, ed 2, Washington, ASM Press, 1994, pp 79-90.
4. Balwit JM, van Langevelde P, Vann JM, Proctor RA: Gentamicin-resis-tant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. J Infect Dis 1994:170:1033-1037.
5. Musher DM, Baughn RE, Templeton GB, Minuth JN: Emergence of variant forms of Staphylococcus aureus after exposure to gcntamicin and infectivity of the variants in experimental animals. J Infect Dis 1977;136:360-369.
6. Proctor RA, van Langevelde P, Kristjansson M, Maslow JN, Arbeit RD: Persistent and relapsing infections associated with small-colony variants of Staphylococcus aureus. Clin Infect Dis 1995;20:95-102.
7. Proctor RA, Balwit JM, Vesga O: Variant subpopulations of Staphylococcus aureus as a cause of persistent and recurrent infections. Infect Agents Dis 1994;3:302-312.
8. Koo SP, Yeaman MR, Sahl H-G, Bayer AS: Staphylocidal action of platelet microbiocidal protein is not solely dependent on intact trans-membrane potential (abstract 41). National Meeting of the Infectious Diseases Society of America, Orlando, 1994.
9. Scott JC, Sahl H-G, Came A, Tagg JR: L-Antibiotic-mediated anti- lactobacillus activity of a vaginal Staphylococcus aureus isolate FEMS Microbiol Lett 1992:93:97-102.
10. Sahl H-G, Jack RW, Bierbaum G: Antibiotics: Biosynthesis and biological activities of peptides with unique post-translational modifications, Eur J Biochem, in press
11. Vessga O, Vann JM, Brar D, Proctor RA: The intracellular milieu favors the production of ultra-small colony variants of 5, aureus. Clin Res 1994; 42:407A.
12. Badcnoch PR, Coster DJ: Selection of gentamicin resistant variants of Pseudomonas aeruginosa in rat cornea. J Ocul Pharmacol 1989:5:19- 25.
13. Baddour LM, Christensen GD, Lo-wrancc JH, Simpson WA: Pathogenesis of experimental endocarditis. Rev Infect Dis 1989:11:452-463