gps mutations in Chilean patients harboring growth hormone-secreting pituitary tumors

Journal of Pediatric Endocrinology and Metabolism

Volumn 12, Issue 3, 1999, Pages 381-387

  Johnson, M Cecilia ^a   Codner, Ethel ^a   Eggers, Martha ^a   Mosso, Lorena ^b   Rodriguez, José A ^b   Cassorla, Fernando ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Acromegaly; Gigantism; gsp oncogene

Indexed keywords

ACROMEGALY; ARTICLE; CASE REPORT; CHILE; GENE MUTATION; GROWTH HORMONE RELEASE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; MALE; SCHOOL CHILD;

EID: 0032995963     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.1999.12.3.381     Document Type: Article

References (23)

1. Billestrup N, Swanson LW, Vale W. Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA 1986; 83: 6854-6857.
2. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl tumours Nature 1989; 340: 692-696.
3. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. Clinical characteristics of acromegalic patients whose pituitary tumours contain mutant Gs protein. J Clin Endocrinol Metab 1990; 71: 1416-1420.
4. Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feitchtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, McCormick F. Two G protein oncogenes in human endocrine tumors. Science 1990; 249: 655-659.
5. Spiegel AM. Mutations in G proteins and G protein-coupled receptors in endocrine disease. J Clin Endocrinol Metab 1996; 81: 2434-2442.
6. Melmed S, Ho K, Klibanski A, Reichlin S, Thorner M. Recent advances in pathogenesis, diagnosis and management of acromegaly. J Clin Endocrinol Metab 1995; 80: 3395-3402.
7. Moran A, Asa SL, Kovacs K, Horvath E, Singer W Sagman U, Reubi JC, Wilson CB, Larson R, Pescovitz OH. Gigantism due to pituitary mammosomatotroph hyperplasia. N Engl J Med 1990; 323: 322-326.
8. Zimmerman D, Young WF, Ebersold MJ, Scheithauer BW, Kovacs K, Horvath E, Whitaker MD, Eberhardt NL, Downs TR, Frohman LA. Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. J Clin Endocrinol Metab 1993; 76: 216-222.
9. Cuttler L, Jackson JA, Saeed-uz-Zafar M, Levitsky LL, Mellinger RC, Frohman LA. Hypersecretion of growth hormone and prolactin in McCune-Albright syndrome. J Clin Endocrinol Metab 1989; 68: 1148-1154.
10. Lighter ES, Winter JS. Treatment of juvenile acromegaly with bromocriptine. J Pediatr 1981; 98: 494-496.
11. Baumann G. Acromegaly. Endocrinol Metab Clin N Am 1987; 16: 685-703.
12. Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G. Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 1990; 71: 1421-1426.
13. Greulich WW, Pyle SI. Radiographic Skeletal Development of the Hand and Wrist, 2nd Ed. Stanford, CA: Stanford University Press, 1959.
14. Cassorla F, Mericq V, Eggers M, Avila A, García C, Fuentes A, Rose SR, Cutler GB. Effects of luteinizing hormone-releasing hormone analog induced pubertal delay in growth hormone (GH)-deficient children treated with GH. Preliminary results. J Clin Endocrinol Metab 1997; 82: 3989-3992.
15. Schwindinger WF, Francomano CA, Levine MA. Identification of a mutation in the gene encoding the α subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci USA 1992; 89: 5152-5156.
16. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991; 325: 1688-1695.
17. α mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome. J Clin Endocrinol Metab 1996; 81: 3839-3842.
18. Mauras N, Blizzard RM. The McCune-Albright syndrome. Acta Endocrinol (Copenh) 1986; Suppl 279: 207-217.
19. Shenker A, Weinstein LS, Moran A, Pescovitz OH, Charest NJ, Boney CM, Van Wyk JJ, Merino MJ, Feuillan PP, Spiegel AM. Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein Gs. J Pediatr 1993; 123: 509-518.
20. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 1990; 71: 1427-1433.
21. Ezzat S, Horvath E, Kovacs K, Smyth HS, Singer W, Asa SL. Basic fibroblast growth factor expression by two prolactin and thyrotropin-producing pituitary adenomas. Endocrine Pathol 1995; 6: 125-134.
22. Lloyd RV, Cano M, Chandler WF, Barkan A, Horvath E, Kovacs K. Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization. Am J Pathol 1989; 134: 605-613.
23. Yang I, Park S, Ryu M, Woo J, Kim S, Kim J, Kim Y, Choi Y. Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. Eur J Endocrinol 1996; 143: 720-726.