Spectroscopic and clinical aspects of noninvasive glucose measurements

Clinical Chemistry

Volumn 45, Issue 2, 1999, Pages 165-177

  Khalil, Omar S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ARTICLE; CALIBRATION; GLUCOSE ASSAY; HUMAN; INFRARED SPECTROSCOPY; LIGHT SCATTERING; METHODOLOGY; OPTICS; POLARIMETRY; RAMAN SPECTROMETRY; REFLECTOMETRY; SPECTROSCOPY; TISSUE;

BLOOD GLUCOSE SELF-MONITORING; HUMANS; SENSITIVITY AND SPECIFICITY; SPECTRUM ANALYSIS;

EID: 0032995738     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (141)

1. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86.
2. The Diabetes Control and Complications Trial Research Group. Lifetime benefits and costs of intensive therapy as practiced in the Diabetes Control and Complications Trial. JAMA 1996;276:1409-15.
3. Ginsberg BH. An overview of minimally invasive technologies. Clin Chem 1992;38:1596-600.
4. Klonoff DC. Non-invasive blood glucose monitoring. Diabetes Care 1997;20:433-7.
5. Heise HM. Non-invasive monitoring of metabolites using near infrared spectroscopy: state of the art. Horm Metab Res 1996;28:527-34.
6. Coté GL. Non-invasive optical glucose sensing-an overview. J Clin Eng 1997;22:253-9.
7. Heise HM, Bittner AB. Blood glucose assays based on infrared spectroscopy: alternatives for medical diagnostics. SPIE Proc 1998;3257:2-12.
8. Colwell JA, Dudley JD, McDonald JM, Metz R, Raskin P, Rizza RA, et al. Consensus statement on self-monitoring of blood glucose. Diabetes Care 1987;10:95-9.
9. Li K-L, Haung H-S, Lin J-D, Huang B-Y, Huang M-J, Wang P-W. Comparing self-monitoring blood glucose devices. Lab Med 1994;25:585-91.
10. Wilson GS, Zhang Y, Reach G, Moatti-Sirat D, Poitout V, Thevenot DR, et al. Progress toward the development of an implantable sensor for glucose. Clin Chem 1992;38:1613-7.
11. Rao G, Glikfeld P, Guy RH. Reverse iontophoresis; development of a noninvasive approach for glucose monitoring. Pharm Res 1993;10:1751-5.
12. Haaland DM. Multivariate calibration. Methods applied to quantitative FT-IR analysis. New York: Academic Press, 1990:385 pp.
13. Martens H, Naes T. Multivariate calibration. New York: John Wiley and Sons, 1989:419 pp.
14. Burmeister JJ, Chung H, Arnold MA. Phantoms for noninvasive blood sensing with near infrared transmission spectroscopy. Photochem Photobiol 1998;67:50-5.
15. Small GW, Arnold MA. Data handling issues for near-infrared glucose measurements. IEEE Lasers Electro-optic Soc Newslett 1998;12:116-7.
16. Arnold MA, Burmeister JJ, Small G. Phantom glucose calibration models from simulated noninvasive human near-infrared spectra. Anal Chem 1998;70:1773-81.
17. Cox D, Clarke W, Gonder-Frederick L, Pohl S, Hoover C, Snyder A, et al. Accuracy of perceiving blood glucose in IDDM. Diabetes Care 1985;8:529-36.
18. Clarke W, Cox D, Gonder-Frederick L, Carter W, Pohl S. Evaluating clinical accuracy of systems for self-monitoring of blood glucose. Diabetes Care 1987;10:622-8.
19. 2O from 0.7 μm to 10 μm. Infrared Phys 1963;3:211-23.
20. Phelan MK, Barlow CH, Kelley JJ, Jinguji TM, Callis JB. Measurement of caustic and caustic brine solutions by spectroscopic detection of the hydroxide ion in the near-infrared region 700-1150 nm. Anal Chem 1989;61:1419-24.
21. Lin J, Brown CW. Near-IR spectroscopic determination of NaCl in aqueous solutions. Appl Spectrosc 1992;46:1809-15.
22. Lin J, Brown CW. Spectroscopic measurement of NaCl and sea water salinity in the near-IR region of 680-1230 nm. Appl Spectrosc 1993;47:239-41.
23. Lin J, Brown CW. Near-IR fiber optic temperature sensor. Appl Spectrosc 1993;47:62-8.
24. Lin J, Brown CW. Universal approach for determination of physical and chemical properties of water by near-IR spectroscopy. Appl Spectrosc 1993;47:1720-7.
25. Kelley JJ, Kelley KA, Barlow CH. Tissue temperature by near-infrared spectroscopy. SPIE Proc 1995;2389:818-28.
26. Wheeler OH. Near-IR spectra of organic compounds. Chem Rev 1959;59:629-66.
27. Vasko PD, Blackwell J, Koenig JL. Infrared and Raman spectroscopy of carbohydrates. I. Identification of O - H and C - H vibrational modes for D-glucose, maltose, cellobiose, and dextran by deuterium substitution methods. Carbohydr Res 1971;19:297-310.
28. PD Vasko, Blackwell J, Koenig JL. Infrared and Raman spectroscopy of carbohydrates. II. Normal coordinate analysis of α-D-glucose. Carbohydr Res 1972;23:407-17.
29. Cael JJ, Koenig JL, Blackwell J. Infrared and Raman spectroscopy of carbohydrates. IV. Identification of configuration and conformation sensitive modes for D-glucose by normal coordinate analysis. Carbohydr Res 1974;32:79-91.
30. Low MJD, Yang RT. The measurement of infrared spectra of aqueous solutions using Fourier transform spectroscopy. Spectrochem Acta 1973;20A:1761-72.
31. Hall JW, Quaresima V, Ferrari M. Can we get more tissue biochemistry information from in vivo near-infrared spectra? SPIE Proc 1995;2387:225-31.
32. Marquardt LA, Arnold MA, Small GW. Near-infrared spectroscopic measurement of glucose in a protein matrix. Anal Chem 1993;65:3271-8.
33. Hazen KH, Arnold MA, Small GW. Temperature-insensitive near-infrared spectroscopic measurements of glucose in aqueous solutions. Appl Spectrosc 1994;48:477-83.
34. Small GW, Arnold MA, Marquardt LA. Strategies for coupling digital filtering with partial least-squares regression: application to the determination of glucose in plasma by Fourier transform near-infrared spectroscopy. Anal Chem 1993;65:3279-89.
35. Arnold MA. Non-invasive glucose monitoring. Curr Opin Biotechnol 1996;7:46-9.
36. Arnold MA. New developments and clinical impact of non-invasive monitoring. In: Kost GJ, ed. Clinical laboratory automation, robotics and knowledge optimization. New York: John Wiley and Sons, 1995:631-47.
37. Chung S, Arnold MA, Rhiel M, Murhammer DW. Simultaneous measurement of glucose and glutamine in aqueous solutions by near infrared spectroscopy. Appl Biochem Biotechnol 1995;40:109-25.
38. Pan H, Chung H, Arnold MA, Small GW. Near-infrared spectroscopic measurement of physiological glucose levels in variable matrices of protein and triglycerides. Anal Chem 1996;68:1124-35.
39. Wilson B, Jacques SL. Optical reflectance and transmittance of tissues: principles and applications. IEEE J Quant Electron 1990;26:2186-99.
40. van Gemert MJC, Jacques SL, Sterenborg HJCM, Star WM. Skin optics. IEEE Trans Biomed Eng 1989;36:1146-54.
41. Cheong WF, Prahl SA, Welch AD. A review of the optical properties of biological tissues. IEEE J Quant Electron 1990;26:2166-85.
42. Saidi IS, Jacques SL, Tittel FK. Mie and Rayleigh modeling of visible-light scattering in neonate skin. Appl Opt 1995;34:7410-8.
43. Jobsis FF. Non-invasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 1977;198:1264-7.
44. Mendelson Y. Pulse oximetry: theory and applications for noninvasive monitoring. Clin Chem 1992;38:1602-7.
45. Shepard AP, Oberg PA eds. Laser-Doppler blood flowmetry. Boston, MA: Kluwar Academic Publishers, 1990:395 pp.
46. Edwards AD, Richardson C, Van der Zee P, Elwell C, Wyatt JS, Cope M, Delpy DT, Reynolds EOR. Measurement of hemoglobin flow and blood flow by near-IR laser Doppler spectroscopy. J Appl Physiol 1993;75:1884-9.
47. Ishimura A. Diffusion of light in turbid material. Appl Opt 1989;28:2210-5.
48. Star WM. Diffusion theory of light transport. In: Welch AJ, Van Gemert MCC, eds. Optical-thermal response of laser-irradiated tissue. New York: Plenum Press, 1995:131-231.
49. Flock ST, Patterson M, Wilson B, Wyman DR. Monte Carlo modeling of light propagation in highly scattering tissue. I. Model prediction and comparison with diffusion theory. IEEE Trans Biomed Eng 1989;36:1162-8.
50. Flock ST, Wilson B, Patterson M. Monte Carlo modeling of light propagation in highly scattering tissue. II. Comparison with measurements in phantoms, IEEE Trans Biomed Eng 1989;36:1169-73.
51. Graaff R, Aarnoudse JG, Zijp JR, Sloot PMA, de Mul FFM, Greve J, Koelink MH. Reduced light-scattering properties for mixture of spherical particles: a simple approximation derived from Mie calculations. Appl Opt 1992;31:1370-6.
52. Wilson B. Measurement of tissue optical properties: methods and theories. In: Welch AJ, Van Gemert MCC, eds. Optical-thermal response of laser-irradiated tissue. New York: Plenum Press, 1995:233-61.
53. Groenhuis RAJ, Ten Bosch JJ, Ferwerda HA. Scattering and absorption of turbid materials from reflection measurement. 1, Theory. Appl Opt 1983;22:2456-62.
54. Groenhuis RAJ, Ten Bosch JJ, Ferwerda HA. Scattering and absorption of turbid materials from reflection measurement. 2. Measuring method and calibration. Appl Opt 1983;22:2463-7.
55. Kienle A, Lilge L, Patterson M, Hibst R, Steiner R, Wilson B. Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of optical scattering and absorption coefficients of biological tissue. Appl Opt 1996;35:2304-14.
56. Farrell T, Patterson M, Wilson B. A diffusion theory model for the non-invasive determination of tissue optical properties in-vivo. Med Phys 1992;19:879-88.
57. Farrell T, Wilson B, Patterson M. The use of neural network to determine tissue optical properties from diffuse reflectance measurements. Phys Med Biol 1992;37:2281-6.
58. Patterson M, Moulton JD, Wilson B, Berndt KW, Lakowicz JR. Frequency-domain reflectance for the determination of the scattering and absorption properties of tissues. Appl Opt 1991;30:4474-6.
59. Patterson M. Frequency domain measurements of light propagation. In: Welch AJ, Van Gemert MCC, eds. Optical-thermal response of laser-irradiated tissue. New York: Plenum Press, 1995:333-64.
60. Maier J, Walker S, Fantini S, Franceschini M, Gratton E. Non-invasive glucose determination by measuring variations of the reduced scattering coefficient of tissues in the near-infrared. Opt Lett 1994;19:2062-4.
61. Kohl M, Cope M, Essenpreis M, Boecker D. Influence of glucose concentration on light scattering in tissue simulating phantoms. Opt Lett 1994;19:2170-2.
62. Kohl M, Essenpreis M, Cope M. The influence of glucose concentration upon the transport of light in tissue-simulating phantoms. Phys Med Biol 1995;40:1267-87.
63. Liu H, Beauvoit B, Kimura M, Chance B. Dependence of tissue optical properties on solute-induced changes in refractive index and osmolality. J Biomed Opt 1996;1:200-11.
64. Chance B, Liu H, Kitai T, Zhang Y. Effect of solutes on optical properties of biological materials: models, cells, and tissues. Anal Biochem 1995;227:351-62.
65. Fantini S, Franceschini-Fantini MA, Maier JS, Walker SA, Barbieri B, Gratton E. Frequency-domain multichannel optical detector for non-invasive tissue spectroscopy and oximetry. Opt Eng 1995;34:32-42.
66. Weast RC, ed. Handbook of chemistry and physics, 58th ed. Cleveland, OH: CRC Press, 1978:D218-76, E233.
67. Qu J, Wilson B. Monte Carlo modeling studies of the effect of physiological factors and other analytes on the determination of glucose concentration in vivo by near infrared optical absorption and scattering measurements. J Biomed Opt 1997;2:319-25.
68. Svaarand LO, Norvarg LT, Fiskertrand EJ, Stepps EKS, Berns MW, Nelson JS. Tissue parameters determining the visual appearance of portwine stain. Br J Dermatol 1995;132:245-50.
69. Robinson MR, Eaton RP, Haaland DM, Keep GW, Thomas EV, Stalled BR, Robinson PL. Noninvasive glucose monitoring in diabetic patients: a preliminary evaluation. Clin Chem 1992;38:1618-22.
70. Haaland DM, Robinson MR, Keep GW, Thomas EV, Eaton RP. Reagentless near-infrared determination of glucose in whole-blood using multivariate calibration. Appl Spectrosc 1992;46:1575-8.
71. Ward KJ, Haaland DM, Robinson MR, Eaton RP. Postprandial blood-glucose determination by quantitative midinfrared spectroscopy. Appl Spectrosc 1992;46:959-65.
72. Heise HM, Marbach R, Janatsch G, Kruse-Jarres JD. Multivariate determination of glucose in whole blood by attenuated total reflection infrared spectroscopy. Anal Chem 1989;61:2009-15.
73. Heise HM, Marbach R, Koschinsky TH, Gries FA. Non-invasive blood glucose sensors based on near-infrared spectroscopy. Artif Org 1994;18:439-47.
74. Heise HM, Marbach R, Koschinsky TH, Gries FA. Multicomponent assay for blood substrates in human plasma by mid-infrared spectroscopy and its evaluation for clinical analysis. Appl Spectrosc 1993;47:875-81.
75. Heise HM, Marbach R. Effect of data pretreatment on the non-invasive blood glucose measurement by diffuse reflectance near-IR spectroscopy. SPIE Proc 1994;2089:114-5.
76. Heise HM, Bittner A. Multivariate calibration for physiological samples using infrared spectra with choice of different intensity data. J Mol Struct 1995;348:127-30.
77. Marbach R, Koschinsky TH, Gries FA, Heise HM. Non-invasive glucose assay by near-infrared diffuse reflectance spectroscopy of the human inner lip. Appl Spectrosc 1993;47:875-81.
78. Jagemann KU, Fischbacher C, Danzer K, Muller UA, Mertes B. Application of near-infrared spectroscopy for non-invasive determination of blood/tissue glucose using neural network. Z Phys Chem 1995;191S:179-90.
79. Muller UA, Mertes B, Fischbacher CF, Jagemann KU, Danzer K. Non-invasive blood glucose monitoring by means of new infrared spectroscopic methods for improving the reliability of the calibration models. Int J Artif Organs 1997;20:285-90.
80. Fischbacher C, Jagemann KU, Danzer K, Muller UA, Papenkrodt L, Schuler J. Enhancing calibration models for non-invasive near-infrared spectroscopical blood glucose determinations. Fresenius J Anal Chem 1997;359:78-82.
81. Khalil G, Malin SF, inventors. Method and apparatus for multispectral analysis in noninvasive infrared spectroscopy. US patent 5,747,806, 1998.
82. Brumeister J, Arnold MA, Small G. Human non-invasive measurement of glucose using near infrared spectroscopy [Abstract]. Pittcon 1998, New Orleans, LA, March 1-5, 1998.
83. Rosenthal RD, inventor. Instrument for non-invasive measurement of blood glucose. US patent 5,077,476, 1991.
84. Rosenthal RD, inventor. Method for providing custom calibration for near infra red instruments for measuring blood glucose. US patent 5,068,536, 1991.
85. Rosenthal RD, Paynter LN, Mackie LH, inventors. Non-invasive measurements of blood glucose. US patent 5,028,787, 1991; US patent 5,086,229, 1992.
86. Rosenthal R. Research in noninvasive measurement of blood glucose by near-infrared technology. Clin Chem 1992;38:1645.
87. Rosenthal RD, inventor. Method for providing general calibration for near Infrared instruments for measurement of blood glucose. US patent 5,204,532, 1993; US patent 5,576,544, 1996.
88. Rosenthal RD, inventor. Method, apparatus for near-infrared quantitative analysis. US patent 5,703,364, 1997.
89. Purdy DL, Wiggins RL, Castro P, inventors. Non-invasive determination of analyte concentration using non-continuous radiation. US patent 5,360,004, 1994.
90. Purdy DL, Palumbo P, DiFransesco M, inventors. Method for non-invasive measurement of concentration of analyte in blood using continuous radiation. US patent 5,460,177, 1995.
91. Barnes RH, Brasch JW, Purdy DL, Lougheed WD, inventors. Non-invasive determination of analyte concentration in body of animals. US patent 5,379,764, 1995.
92. Harjunmaa H, inventor. Method for determining by absorption of radiation the concentration of substances in absorbing and turbid matrices. US patent 5,099,123, 1992.
93. Harjunmaa H, Peura RA, Mendelson Y, inventors. Method and apparatus for measuring the concentration of absorbing substances. US patent 5,112,124, 1992.
94. Mendelson Y, Peura RA, Harjunmaa H, inventors. Method and apparatus for monitoring blood analysis noninvasively by pulsatile photoplethysmography. US patent 5,137,023, 1992.
95. Harjunmaa H, Mendelson Y, Wang Y, inventors. Electromagnetic method and apparatus to measure constituents of human or animal tissue. US patent 5,178,142, 1993; US patent 5,183,042, 1993.
96. Block MJ. Introducing Kromoscopic analysis: a new technique for non-invasive in vivo measurement of trace constituent concentration. Photonic Spectra 1994;28:135-9.
97. Sodickson LA, Block MJ. Kromoscopic® analysis: a possible alternative to spectroscopic analysis for non-invasive measurements. Clin Chem 1994;40:1838-44.
98. Block MJ, Sodickson LA, inventors. Non-invasive non-spectrophotometric infrared measurement of blood analyte concentrations. US patent 5,424,545, 1995.
99. Sodickson LA, Block MJ, inventors. Non-spectrophotometric infrared measurement of analyte concentrations and optical properties of objects. US patent 5,434,412, 1995.
100. Sodickson LA. Improvements in multivariate analysis via Kromoscopic measurements. Spectroscopy 1997;12:13-24.
101. Misner MW, Block MJ. The raw data of Kromoscopic analysis. Spectroscopy 1997;12:20-1.
102. Bruulsema JT, Hayward JE, Farrell T, Patterson M, Heinemann L, Berber M, et al. Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient. Opt Lett 1997;22:190-2.
103. Heinemann L, Schmelzeisen-Redeker G, on behalf of the Non-invasive Task Force. Non-invasive continuous glucose monitoring in Type I diabetic patients with optical glucose sensors. Diabetologia 1998;41:848-54.
104. Simonsen JH, Boecker D, inventors. Method and apparatus for analytical determination of glucose in a biological matrix. US patent 5,551,422, 1996.
105. Gratton E, Maier J, Franceschini MA, Fantini S, Walker A, inventors. Determining material concentration in tissues. US patent 5,492,118, 1996.
106. Gratton E, Fantini S, Franceschini MA, Mantulin W, Barbieri B, inventors. Photosensor with multiple light sources. US patent 5,497,769, 1996.
107. Rabinovitch B, March WF, Adams RL. Noninvasive glucose monitoring of the aqueous humor of the eye. I. Measurement of very small optical rotations. Diabetes Care 1982;5:254-8.
108. March W, Rabinovitch B, Adams R. Noninvasive glucose monitoring of the aqueous humor of the eye. II. Animal studies and the scleral lens. Diabetes Care 1982;5:259-65.
109. Cough DA. The composition and optical rotary dispersion of bovine aqueous humor. Diabetes Care 1982;5:266-70.
110. Coté GL, Fox MD, Northrop RB. Noninvasive optical polarimetric glucose sensing using a true phase measurement technique. IEEE Trans Biomed Eng 1992;39:752-6.
111. Coté GL, Fox MD, Northrop RB, inventors. Optical glucose sensor apparatus and method. US patent 5,209,231, 1993.
112. King M, Coté GL, McNichols R, Goetz MJ. Multispectral polarimetric glucose detection using a single Pockels cell. Opt Eng 1994;33:2746-52.
113. Cameron BD, Coté GL. Polarimetric detection of chiral chemicals in biological fluids. SPIE Proc 1997;2982:308-13.
114. Coté GL, Cameron BD. Noninvasive polarimetric measurement of glucose in cell culture media. J Biomed Opt 1997; 2:275-81.
115. Hutchinson DP, inventor. Device for non-invasive determination of blood glucose. US patent 5,009,230, 1991.
116. Vickers TJ, Mann CK. Quantitative analysis by Raman spectroscopy. In: Garassili JG, Bulkin BJ, eds. Analytical Raman spectroscopy. New York: Wiley, 1991:107-35.
117. Lombardi DJ, Wang C, Sun B, Fountain AW III, Vickers JJ, Mann CK, et al. Quantitative and qualitative analysis of some inorganic compounds by Raman spectroscopy. Appl Spectrosc 1994;48:875-83.
118. Berger AJ, Wang Y, Feld MS. Rapid, noninvasive concentration measurements of aqueous biological analytes by near-infrared Raman spectroscopy. Appl Opt 1996;35:209-12.
119. Xu J, Ford JF, Mann CK, Vickers TJ, Brackett JM, Cousineau KL, Robey WG. Raman measurements in bioreactor materials. SPIE Proc 1997;2976:10-9.
120. Erkens RJ, Wicksted JP, Motamedi M, March WF. Monitoring of glucose, urea and lactate through the animal cornea using laser Raman spectroscopy. Investig Ophth Vis Sci 1994;35:2054.
121. Wicksted JP, Erkens RJ, Motamedi M, March WF. Raman spectroscopy studies of metabolic concentrations in aqueous solutions and in aqueous humor species. Appl Spectrosc 1995;49:987-93.
122. Yang SY, Hasty CE, Watson PA, Wicksted JP, Smith RD, March WF. Analysis of metabolites in aqueous solutions by using laser Raman spectroscopy. Appl Opt 1993;32:925-9.
123. Goetz MJ Jr, Cote GL, Erkens RJ, March WF, Motamedi M. Application of multivariate technique to Raman spectra for quantification of body chemicals. IEEE Trans Biomed Eng 1995:42:728-31.
124. Bell AF, Barron LD, Hech L. Vibrational Raman optical activity study of D-glucose. Carbohydr Res 1994;257:11-24.
125. Dou X, Yamaguchi Y, Yamamato H, Harumi H, Ozaki Y. Biological applications of anti-Stokes Raman spectroscopy: quantitative analysis of glucose in plasma and serum by a highly sensitive multichannel Raman spectrometer. Appl Spectrosc 1996;50:1301-6.
126. Dou X, Uenoyama H, inventors. Apparatus and method for measuring concentration of components with light scattering. US patent 5,481,113, 1996.
127. Tanaka K, Pacheco MTT, Brennan JF III, Itzkan I, Berge AJ, Dasari RR, Feld MS. Compound parabolic concentrator probe for efficient light collection in spectroscopy of biological tissues. Appl Opt 1996; 35:758-63.
128. Berger AJ, Brennan JF III, Dasari RR, Feld MS, Itzkan I, Tanaka K. Apparatus and method of Raman spectroscopy for analysis of blood gases and analytes. International patent WO96/29925. International publication published under the Patent Cooperation Treaty (PCT), 1996
129. Tarr RV, Tarr PGS, inventors. Non-invasive blood glucose measurement system and method using simulated Raman spectroscopy. US patent 5,243,983, 1993.
130. Kunst H. Transcutaneous, non-bloody determination of the concentration of substances in the blood. International patent WO95/31928. International application published under the Patent Cooperation Treaty (PCT), 1995.
131. Quan KM, Christison GB, MacKenzie HA, Hodgson P. Glucose determination by pulsed photoacoustic technique: an experimental study using a gelatin-based tissue phantom. Phys Med Biol 1993;38:1911-22.
132. Christison GB, MacKenzie HA. Laser photoacoustic determination of physiological glucose concentration in human whole blood. Med Biol Eng Comput 1993;31:284-90.
133. Spanner G, Niessner R. A photoacoustic laser sensor for the non-invasive determination of blood contents. Anal Methods Instrum 1993:1:208-12.
134. Spanner G, Niessner R. New concept for the non-invasive determination of physiological glucose concentrations using modulated laser diodes. Fresenius J Anal Chem 1996;354:306-10.
135. Spanner G, Niessner R. Noninvasive determination of blood constituents using an array of modulated laser diodes and a photoacoustic sensor head. Fresenius J Anal Chem 1996;355:327-8.
136. Duncan A, Hannigan J, Freeborn SS, Rae PWH, McIver B, Creig F, et al. A portable non-invasive blood glucose monitor. Eighth International Conf Solid State Sensors and Actuators and Euro-sensors IX. Stockholm, Sweden, 1995:455-8.
137. MacKenzie HA, Ashton HS, Shen YC, Lindberg J, Rae P, Quan PM, Spies S. Blood glucose measurements by photoacoustics [Abstract]. Trends Opt Photonics 1998;22:156-9.
138. Braig JR, Goldberger DS, Sterling BB, inventors. Self-emission non-invasive spectrophotometer with body temperature compensation. US patent 5,516,672, 1997.
139. Klonoff DC, Braig JR, Sterling BB, Kramer C, Goldberger DS, Trebino Y. Mid-infrared spectroscopy for non-invasive blood glucose monitoring. IEEE Laser Electro-optics Soc Newslett 1998;12:13-4.
140. Buchert JM, inventor. Instrument, method for non-invasive monitoring of human tissue analytes by measuring the body infrared radiation. US patent 5,666,956, 1997.
141. Cho O-K, Hoizgreve B, inventors, Process and device for non-invasive determination of glucose concentration in parts of the human body, US patent 5,795,305, 1998.