Aminoaciduria resulting from vigabatrin administration in children with epilepsy

Pediatric Neurology

Volumn 21, Issue 1, 1999, Pages 460-463

  Lahat, Eli ^a   Ben Zeev, Bruria ^a   Zlotnik, Joseph ^b   Sela, Ben Ami ^b  

^a Pediat Neurol U Assaf Harofeh M   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 METHYLPROPIONIC ACID; 4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID; BETA ALANINE; CARBOXYLIC ACID; CARNOSINE; GLUTAMIC ACID; VIGABATRIN;

ADOLESCENT; AMINOACIDURIA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPSY; FEMALE; HUMAN; INFANT; MALE; PRIORITY JOURNAL;

ADOLESCENT; AMINO ACIDS; AMINOISOBUTYRIC ACIDS; ANTICONVULSANTS; BETA-ALANINE; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; INFANT; MALE; VIGABATRIN;

EID: 0032993539     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-8994(99)00022-3     Document Type: Article

References (17)

1. Munford J., Dulac O. Vigabatrin A new epileptic medication . J Child Neurol. 6:1991;253-256.
2. Ben-Menachem E. Vigabatrin. Epilepsia. 36:(Suppl 2):1996;S95-S104.
3. French J., Mosier M., Walker S., Somerville K., Sussman N. A double-blind placebo-controlled study of vigabatrin 32 gm/day in patients with uncontrolled complex partial seizures. Neurology. 46:1996;54-61.
4. Marson A.G., Kadir Z.A., Hutton J.L., Chadwick D.W. The new antiepileptic drugs A systemic review of their efficacy and tolerability . Epilepsia. 38:1997;859-880.
5. Richens A. Pharmacology and clinical pharmacology of vigabatrin. J Child Neurol 1991;6:2S7-10.
6. Brandt N.J., Christensen E. W-aminoaciduria induced by γ-vinyl-GABA. Lancet. 1984:1984;450-451.
7. Bonham J.R., Rattenbury J.M., Meeks A., Pollitt R.J. Pyroglutamic aciduria from vigabatrin. Lancet. 1989:1989;1452-1453.
8. Shih V.E., Tenanbaum A. Aminoaciduria due to vinyl-GABA administration. N Engl J Med. 323:1990;1353.
9. Preece M.A., Sewell I.J., Taylor J.A., Green A. Vigabatrin-interference with urinary amino acid analysis. Clin Chim Acta. 218:1993;113-116.
10. Fowler B. Amino acids. Gowenlock A.H. Varley's practical clinical biochemistry. 6th ed. 1988;368-400 Heinemann Medical Books, London.
11. Edwards M.A., Grant S.M., Green A. A practical approach to the investigation of amino acid disorders. Ann Clin Biochem. 25:1988;129-141.
12. Ben-Menachem E., Persson L., Schechter P.J.U. Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxy indoleacetic acid in patients with complex partial epilepsy. Epilepsy Res. 2:1988;96-101.
13. Rey E., Pons G., Richard M.O. Pharmacokinetics of the individual encardiomers of vigabatrin (γ-vinyl GABA) in epileptic children. Br J Clin Pharmacol. 30:1990;253-257.
14. Scriver C.R., Pueschel S., Davies E. Hyper-β-alaninemia associated with β-aminoaciduria and γ-aminobutyricaciduria, somnolence and seizures. N Engl J Med. 274:1986;635-643.
15. Jaeken J., Eggermont J., Casaer P., Corbed L., Eeckels R. γ-vinyl GABA, and GABA and β-alanine transamination. Lancet. 737:1984.
16. Grove J., Schechter P.J., Tell G. Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid). Life Sci. 28:1981;2431-2439.
17. Vallat C., Rivier F., Bellet H., Magnan de Bornier B., Mion H., Echenne B. Treatment with vigabatrin may mimic alpha-aminoadipic aciduria. Epilepsia. 37:1996;803-805.