Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen

Cancer Research

Volumn 57, Issue 4, 1997, Pages 728-734

  Pervin, Shehla ^a   Chakraborty, Mala ^a   Bhattacharya Chatterjee, Malaya ^a   Zeytin, Hasan ^a   Foon, Kenneth A ^a   Chatterjee, Sunil K ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; CARCINOEMBRYONIC ANTIGEN; FREUND ADJUVANT; HEMOCYANIN;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; ENZYME INDUCTION; GASTROINTESTINAL CARCINOMA; HOST RESISTANCE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; TUMOR IMMUNITY;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CANCER VACCINES; CARCINOEMBRYONIC ANTIGEN; FEMALE; HEMOCYANIN; HUMANS; IMMUNITY, CELLULAR; IMMUNOTHERAPY; MICE; MICE, INBRED C57BL; TUMOR CELLS, CULTURED;

EID: 0031051459     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Jerne, N. K. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur), 125C: 373-389, 1974.
2. Bona, C. A., and Köhler, H. Antiidiotypic antibodies and internal images in mono- clonal and anti-idiotypic antibodies. In: J. C. Venter, C. M. Fraser, and J. Linstrom (eds.). Monoclonal and Anti-Idiotypic Antibodies: Probes for Receptor Structure and Function, pp. 141-149. New York: Alan R. Liss, 1984.
3. Sacks, D. L., Kirchhoff, L. V., Hieny. S., and Sher, A. Molecular mimicry of a carbohydrate epitope on a major surface glycoprotein of Trypanosoma cruzi by using anti-idiotypic antibodies. J. Immunol., 135: 4155-4159, 1985.
4. Haubeck, H. D., and Kolsch, E. Regulation of immune responses against the syngeneic ADJ-PC-5 plasmacytoma in BALB-c mice. III. Induction of specific T suppressor cells to the BALB/c plasmacytoma ADJ-PC-5 during early stages of tumorigenesis. Immunology. 47: 503-510, 1982.
5. Howie, S. M., and McBride, W. H. Tumor specific T helper activity can be abrogated by two distinct suppressor cell mechanisms. Eur. J. Immunol., 12: 671-675, 1982.
6. Greene, M. I. Cellular and genetic basis of immune reactivity to tumor cells, Contemp. Top. Mol. Immunol., 11: 81-116, 1980.
7. McBride. W. H., and Howie. S. M. Induction of tolerance to a murine fibrosarcoma in two zones of doses - the involvment of suppressor cells. Br. J. Cancer, 53: 707-711, 1986.
8. Bhattacharya-Chatterjee, M., Mukerjee, S., Biddle, W., Foon, K. A., and Köhler, H. Murine monoclonal anti-idiotype antibody as a potential network antigen for human carcinoembryonic antigen. J. Immunol., 145: 2758-2765, 1990.
9. Muraro, R., Wunderlich, D., and Thor, A. Definition by monoclonal antibodies of repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues. Cancer Res., 45: 5769-5780, 1985.
10. Steward, A. M., Nixon, D., Zamcheck, N., and Aisenberg, A. Carcinoembryonic antigen in breast cancer patients: serum levels and disease progress. Cancer (Phila.), 33: 1246-1252, 1974.
11. Vincent, R. G., and Chu, T. M., Carcinoembryonic antigen in patients with carcinoma of the lung. J. Thorac. Cardiovasc. Surg., 66: 320-328, 1978.
12. Chakraborty, M., Foon, K. A., Köhler, H., and Bhattacharya-Chatterjee, M. Pre-clinical evaluation in non-human primates of an anti-idiotypic antibody that mimicks carcinoembryonic antigen. J. Immunother., 18: 95-103, 1995.
13. Foon, K. A., Chakraborty, M., John, W. J., Sherratt, A., Köhler, H., and Bhattacharya-Chatterjee, M. Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J. Clin. Invest., 96: 334-342, 1995.
14. Fox, B. A., Spiess, P. J., Kasid, A., Pun, R., Mulé, J. J., Weber, J. S., Rosenberg, S. A. In vitro and in vivo anti-tumor properties of a T-cell clone generated from murine tumor infiltrating lymphocytes. J. Biol. Response Mod., 9: 499-511, 1990.
15. Robbins, P. F., Kantor, J. A., Salgaller, M., Hand, P. H., Fernsten, P. D., and Schlom, J. Transduction and expression of human carcinoembryonic antigen gene in a murine colon carcinoma cell line. Cancer Res., 51: 3657-3662, 1991.
16. Bhattacharya-Chatterjee, M., Mrozek, E., Mukerjee, S., Ceriani, R. L., Köhler, H., and Foon, K. A. Anti-idiotype antibodies as potential therapeutic agents for human breast cancer. In: R. L. Ceriani (ed.) Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment, pp. 139-148. New York: Plenum Publishing Corp., 1994.
17. Bhattacharya-Chatterjee, M., Mrozek, E., Chakraborty, M., Reisfeld, R. A., Köhler, H., and Foon, K. A. Syngeneic monoclonal anti-idiotype antibodies against a monoclonal antibody to human melanoma associated antigen. J. Immunol., 150: 142A, 1993.
18. Bhattacharya-Chatterjee, M., Chatterjee, S. K., Valis, S., Seon, B., and Köhler, H. Idiotype vaccines against human T cell leukemia. II. Generation and characterization of a monoclonal idiotype cascade (Abl, Ab2, and Ab3). J. Immunol., 141: 1398-1403, 1988.
19. Pervin, S., Sherratt, A., Wang, H-T., Blalock, E. J., Bhattacharya-Chatterjee, M., Köhler, H., Foon, K. A., and Chatterjee, S. K. Proliferation of T-cells from colon cancer patients by peptides based on the structure of an anti-idiotype antibody mimicking CEA. Proc. Am. Assoc. Cancer Res., 37: 473, 1996.
20. Oikawa, S., Nakazato, H., and Kosaki, G. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem. Biophys. Res. Commun., 142: 511-518, 1987.
21. Paxton, R. J., Mooser, G., Pande, H., Lee, T. D., and Shively, E. Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin super-gene family. Proc. Natl. Acad. Sci. USA, 84: 920-924, 1987.
22. Beauchemin, N., Benchimol, S., Coumoyer, D., Fuks, A., and Stanners, C. P. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Mol. Cell. Biol., 7: 3222-3230, 1987.
23. Egan. M. L., Pritchard, D. G., Todd, C. W., and Go, V. L. W. Isolation and immunochemical and chemical characterization of carcinoembryonic antigen-like substances in colon lavages of healthy individuals. Cancer Res., 37: 2638-2643, 1977.
24. Pritsche. R., and Mach. J-P, Isolation and characterization of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa. Immunochemistry, 14: 119-127, 1977.
25. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., and Stanners. C. P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell, 57: 327-334, 1989.
26. Thomas, P., Toth, C. A., Saini. K. S., Jessup. J. M., and Steele, G. D. The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochim. Biophys. Acta. 1032: 177-189, 1990.
27. Wagner, H. E., Toth, C. A., Steele, G. D., and Thomas, P. Invasive and metastatic potential of human colorectal cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production. Clin. Exp. Metastasis, 10: 25-31, 1992.
28. Hostetter, R. B., Campbell, D. E., Kerckhoff, S., Cleary, K. R., Ullrich, S., Thomas, P., and Jessup, J. M. Carcinoembryonic antigen enhances metastatic potential of colorectal carcinoma. Arch. Surg., 725: 300-304, 1990.
29. Shively, J. E., and Beatty, J. D. CEA related antigens: molecular biology and clinical significance. Crit. Rev. Oncol. Hematol., 2: 355-399, 1985.
30. Jessup, J. M., Giavazzi, R., Campbell, D., Cleary, R., Morikawa, K., and Fidler, I. J. Growth potential of human colorectal carcinomas in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen. Cancer Res., 48: 1689-1692, 1988.
31. Hashino, J., Fukuda, Y., Oikawa, S., Nakazato, H., and Nakanishi, T. Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen. Clin. Exp. Metastasis, 12: 324-328, 1994.
32. Pendurthi, T. K., Parker, R., Schlom, J., and Primus, J. Lymphokine-activated killer cell cytotoxicity against human colon carcinomas enhanced by monoclonal antibody D612. Int. J. Cancer, 46: 1021-1028, 1990.
33. Herlyn, D., Herlyn, M., Steplewski, Z., and Koprowsky, H. Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma. Eur. J. Immunol., 9: 657-659, 1979.
34. 2a antibodies to tumors destroy human cancer cells. Science (Washington DC), 221: 865-867, 1983.
35. 2a antibody that reacts with most human carcinomas. Proc. Natl. Acad. Sci. USA, 83: 7059-7063, 1986.
36. Bei, R., Moretti, A., Visco, V., DeFilippi, R., Tsang, K., Frati, L., and Muraro, R. Cell mediated cytotoxicity of human colon carcinoma cells by a monoclonal antibody (R4) recognizing the carcinoembryonic antigen (CEA) and CEA-related molecules. Int. J. Oncol., 8: 1127-1135, 1996.
37. Durrant, L. G., Buckley, T. J. D,. Denton, G. W. L., Hardcastle, J. D. Sewell, H. F., and Robins, R. A. Enhanced cell-mediated tumor killing in patients immunized with human monoclonal anti-idiotypic antibody 105AD7. Cancer Res., 54: 4837-4840, 1994.
38. Durrant, L. G., Doran, M., Austin, E. B., and Robins, R. A. Induction of cellular immune responses by a murine monoclonal anti-idiotypic antibody recognizing the 791Tgp72 antigen expressed on colorectal, gastric and ovarian human tumors. Int. J. Cancer, 61: 62-66, 1995.
39. Somasundaran, R., Zaloudik, J., Jacob, L., Benden, A., Sperlagh, M., Hart, E., Marks, G., Kane, M., Mastrangelo, M., and Herlyn. D. Induction of an antigen-specific T and B cell immunity in colon carcinoma patients by anti-idiotypic antibody. J. Immunol., 155: 3253-3261, 1995.
40. Fagerberg, J., Steinnitz, M., Wigzell, H., Askelöf, P., and Mellstedt, H. Human anti-idiotypic antibodies induced a humoral and cellular immune response against a colorectal carcinoma-associated antigen in patients. Proc. Natl. Acad. Sci. USA, 92: 4773-4777, 1995.
41. Fagerberg, J., Hjelm, A-L., Ragnhammar, P., Frödin, J-E., Wigzell, H., and Mellstedt, H. Tumor regression in monoclonal antibody-treated patients correlates with the presence of anti-idiotype-reactive T lymphocytes. Cancer Res., 55: 1824-1827, 1995.