A physiological model for predicting carboxyhemoglobin formation from exposure to carbon monoxide in rats

Journal of Applied Physiology

Volumn 86, Issue 6, 1999, Pages 1977-1983

  Kimmel, Edgar C ^a,b   Carpenter, Robert L ^b   Reboulet, James E ^a   Still, Kenneth R ^b  

^a SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

^b WRIGHT PATTERSON AIR FORCE BASE   (United States)

Author keywords

Carbon monoxide exposure; Carboxyhemoglobin formation prediction; Coburn Forster Kane equation; Numerical models

Indexed keywords

CARBON MONOXIDE; CARBOXYHEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; BLOOD VOLUME; CARBON MONOXIDE INTOXICATION; ENVIRONMENTAL EXPOSURE; HEMOGLOBIN DETERMINATION; NONHUMAN; OXIMETRY; OXYGEN DISSOCIATION CURVE; PRIORITY JOURNAL; RAT;

EID: 0032992868     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.6.1977     Document Type: Article

References (32)

1. Allen, T. A., and W. S. Root. Partition of carbon monoxide and oxygen between air and whole blood of rats, dogs and men as affected by plasma pH. J. Appl. Physiol. 10: 186-190, 1957.
2. Altman, P. L., and D. S. Dittmer (Editors). Biology Data Book (2nd ed.). Bethesda, MD: FASEB, 1974, vol. III, p. 1413-2123.
3. Andersen, M. E., H. J. Clewell, M. L. Gargas, M. G. MacNaughton, R. H. Reitz, R. J. Nolan, and M. J. McKenna. Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharmacol. 108: 14-27, 1991.
4. Andersen, M. E., H. J. Clewell, M. L. Gargas, F. A. Smith, and R. H. Reitz. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87: 185-205, 1987.
5. Benignus, V. A., and Z. Annau. Carboxyhemoglobin formation due to carbon monoxide exposure in rate. Toxicol. Appl. Pharmacol. 128: 151-157, 1994.
6. Brown, R. P., M. D. Delp, S. L. Lindstedt, L. R. Rhomberg, and R. P. Beliles. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Industr. Health 13: 407-484, 1997.
7. Cannon, W. C., E. F. Blanton, and K. E. McDonald. The flow past chamber: an improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44: 923-928, 1983.
8. Coburn, R. F., R. E. Forster, and P. B. Kane. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J. Clin. Invest. 44: 1899-1910, 1965.
9. Costa, D. L., J. S. Tepper, and J. A. Raub. Interpretations and limitations of pulmonary function testing in small laboratory animals. In: Treatise on Pulmonary Toxicology: Comparative Biology of the Normal Lung, edited by R. A. Parent. Boca Raton, FL: CRC, 1992, vol. I, p. 367-399.
10. Dickenson, C. J. A Computer Model of Human Respiration. Baltimore, MD: University Park Press, 1977, p. 1-18.
11. Douglass, C. G., J. S. Haldane, and J. B. S. Haldane. The laws of combination of haemoglobin with carbon monoxide and oxygen. J. Physiol. (Lond.) 44: 275-304, 1912.
12. Forbes, W. H., F. Sargent, and F. J. W. Roughton. The rate of carbon monoxide uptake in normal man. Am. J. Physiol. 143: 594-608, 1945.
13. Haldane, J. B. S. The action of carbonic oxide on man. J. Physiol. (Lond.) 18: 430-462, 1895.
14. Hanks, T. G., and R. D. Farquhar. Analysis of Human Performance Capabilities as a Function of Exposure to Carbon Monoxide. Geneva: World Health Organization, 1969. (SystMed Rep. R 9001)
15. Haponik, E. F. Clinical and functional assessment. In: Respiratory Injury: Smoke Inhalation and Burns, edited by E. F. Haponik and A. M. Munster. New York: McGraw-Hill, 1990, p. 137-178.
16. Hartzell, G. E. Prediction of the toxic effects of fire effluents. Fire Sci. 7: 179-193, 1989.
17. Hartzell, G. E., H. W. Stacy, W. G. Switzer, D. N. Priest, and S. C. Packham. Modeling of toxicological effects of fire gases. IV. Intoxication of rats by carbon monoxide in the presence of an irritant. In: Advances in Combustion Toxicology, edited by G. E. Hartzell. Lancaster, PA: Technomic, 1989, vol. 2, p. 1-17.
18. Johnson, J. D., D. L. Wetmore, C. W. Martinez, and C. R. Ostrander. Developmental changes in bilirubin production in the rat. J. Pediatr. Gastroenterol. Nutr. 2: 142-151, 1983.
19. Kimmel, E. C. A small animal plethysmograph/exposure tube for determination of respiratory mechanics during exposure, using non-invasive methods to measure intrapleural pressure (Abstract). Toxicol. Sci. 48: 116, 1999.
20. Kimmel, E. C., R. L. Carpenter, E. A. Smith, J. E. Reboulet, and B. H. Black. Physiologic models for comparison of inhalation risk between laboratory and field generated atmospheres of a dry powder fire suppressant. Inhal. Toxicol. 10: 905-922, 1998.
21. Kimmel, E. C., and L. Diamond. The role of nicotine in the pathogenesis of pulmonary emphysema. Am. Rev. Respir. Dis. 129: 112-117, 1984.
22. Mauderly, J. L. Respiration of the F344 rat in nose-only inhalation exposure tubes. J. Appl. Toxicol. 6: 25-30, 1986.
23. Montgomery, M. R., and R. J. Rubin. The effect of carbon monoxide inhalation on in vivo drug metabolism in the rat. J. Pharmacol. Exp. Ther. 179: 465-473, 1971.
24. Pace, N., W. V. Consolazio, W. A. White, Jr., and A. R. Behnke. Formulation of principal factors affecting the rate of uptake of carbon monoxide by man. Am. J. Physiol. 147: 352-359, 1945.
25. Penney, D. G. Hemodynamic response to carbon monoxide. Environ. Health Perspect. 77: 121-130, 1988.
26. Peterson, J. E., and R. D. Stewart. Adsorption and elimination of carbon monoxide by inactive young men. Arch. Environ. Health 21: 165-171, 1970.
27. Sabo, J., E. C. Kimmel, and L. Diamond. The effects of the Clara cell toxin, 4-ipomeanol, on pulmonary function in rats. J. Appl. Physiol. 54: 337-344, 1983.
28. Sanders, D. C., and B. R. Endecott. The effect of elevated temperature on carbon monoxide-induced incapacitation. J. Fire Sci. 9: 297-310, 1991.
29. Sanders, D. C., B. R. Endecott, R. M. Ritter, and A. K. Chaturvedi. Variations of Time-to-Incapacitation and Carboxyhemoglobin Values in Rats Exposed to Two Carbon Monoxide Concentrations. Washington, DC: Dept. of Transportation, FAA, Office of Aviation Medicine, 1993, p. 1-15, A1-A5. (Dept. of Transportation Technical Rep. DOT/FAA/AM-93/7)
30. Silbaugh, S. A., and S. M. Horvath. Effect of acute carbon monoxide exposure on cardiopulmonary function in the awake rat. Toxicol. Appl. Pharmacol. 66: 376-382, 1982.
31. Tyuma, I., Y. Ueda, K. Imaizumi, and H. Kosaka. Prediction of carboxyhemoglobin levels during and after carbon monoxide exposures in various animal species. Jpn. J. Physiol. 31: 131-143, 1981.
32. World Health Organization. Carbon Monoxide. Geneva: World Health Organization, 1979. (Environmental Health Criteria 13 Ser.)