LOH and mutational analysis of p53 alleles in mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl) nitrosamine

Carcinogenesis

Volumn 20, Issue 4, 1999, Pages 715-718

  Morimura, Keiichirou ^a   Yamamoto, Shinji ^a   Murai, Takashi ^b   Mori, Satoru ^b   Chen, Tian Xin ^a   Wanibuchi, Hideki ^a   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; PROTEIN P53;

ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CARCINOGENESIS; BLADDER CARCINOMA; CROSS BREEDING; DNA SEQUENCE; EXON; GENE MUTATION; GENETIC POLYMORPHISM; MALE; MOUSE; NONHUMAN; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR BIOPSY;

EID: 0032992271     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.4.715     Document Type: Article

References (29)

1. Levine, A.J. (1993) The tumor suppressor genes. Ann. Rev. Biochem., 62, 623-651.
2. Knowles, M.A., Elder, P.A., Williamson, M., Cairns, J.P., Shaw, M.E. and Law, M.G. (1994) Allelotype of human bladder cancer. Cancer Res., 54, 531-538.
3. Cairns, P., Proctor, A.J. and Knowles, M.A. (1991) Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma. Oncogene, 6, 2305-2309.
4. Cairns, P., Shaw, M.E. and Knowles, M.A. (1993) Initiation of bladder cancer may involve deletion of a tumour-suppressor gene on chromosome 9, Oncogene, 8, 1083-1085.
5. Cairns, P., Shaw, M.E. and Knowles, M.A. (1993) Preliminary mapping of the deleted region of chromosome 9 in bladder cancer. Cancer Res., 53, 1230-1232.
6. Tsai, Y.C., Nichols, P.W., Hiti, A.L., Williams, Z., Skinner, D.G. and Jones, P.A. (1990) Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer. Cancer Res., 50, 44-47.
7. Fearon, E.R., Feinberg, A.P., Hamilton, S.H. and Vogelstein, B. (1985) Loss of genes on the short arm of chromosome 11 in bladder cancer. Nature, 318, 377-380.
8. Habuchi, T., Ogawa, O., Kakehi, Y., Ogura, K., Koshiba, M., Sugiyama, T. and Yoshida, O. (1992) Allelic loss of chromosome 17p in urothelial cancer: strong association with invasive phenotype. J. Urol., 148, 1595-1599.
9. Oka., K., Ishikawa, J., Bruner, J.M., Takahashi, R. and Saya, H. (1991) Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction. Mol. Carcinogen., 4, 10-13.
10. Miyamoto, H., Shuin, T., Ikeda, I., Hosaka, M. and Kubota, Y. (1996) Loss of heterozygosity at the p53, RB, DCC and APC tumor suppressor gene loci in human bladder cancer. J. Urol., 155, 1444-1447.
11. Fujimoto, K., Yamada, Y., Okajima, E., Kakizoe, T., Sasaki, H., Sugimura, T. and Terada, M. (1992) Frequent association of p53 gene mutation in invasive bladder cancer. Cancer Res., 52, 1393-1398.
12. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C.C. (1991) p53 mutations in human cancers. Science, 253, 49-53.
13. Olumi, A.F., Tsai, Y.C., Nichols, P.W., Skinner, D.G., Cain, D.R., Bender, L.I. and Jones, P.A. (1990) Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder. Cancer Res., 50, 7081-7083.
14. Sidransky, D., Von Eschenbach, A., Tsai, Y.C. et al. (1991) Identification of p53 gene mutations in bladder cancers and urine samples. Science, 252, 706-709.
15. Asamoto, M., Mann, A.M. and Cohen, S.M. (1994) p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo. Carcinogenesis, 15, 455-458.
16. Yamamoto, S., Masui, T., Murai, T., Mori, S., Oohara, T., Makino, S., Fukushima, S. and Tatematsu, M. (1995) Frequent mutations of the p53 gene and infrequent H-and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 16, 2363-2368.
17. Tamano, S., Hagiwara, A., Suzuki, E., Okada, M., Shirai, T. and Fukushima, S. (1991) Time-and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-A-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn. J. Cancer Res., 82, 650-656.
18. Ito, N., Hiasa, Y., Tamai, A., Okajima, E. and Kitamura, H. (1969) Histogenesis of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats. Gann, 60, 401-410.
19. Fukushima, S., Hirose, M., Tsuda, H., Shirai, T. and Hirao, K. (1976) Histological classification of urinary bladder cancers in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann, 67, 81-90.
20. Masui, T., Don, I., Takada, N., Ogawa, K., Shirai, T. and Fukushima, S. (1994) p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 15, 2379-2381.
21. Cohen, S.M., Arai, M., Jacobs, J.B. and Friedell, G.H. (1979) Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. Cancer Res., 39, 1207-1217.
22. Hirose, M., Fukushima, S., Hananouchi, M., Shirai, T. and Ogiso, T. (1976) Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds. Gann, 67, 175-89.
23. Murai, T., Mori, S., Hosono, M., Takeuchi, Y., Ohara, T., Makino, S., Takeda, R., Hayashi, Y. and Fukushima, S. (1991) Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Jpn. J. Cancer Res., 82, 1371-1377.
24. Yamamoto, S., Chen, T., Murai, T. et al. (1997) Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 18, 1877-1882.
25. Bienz, B., Zakut-Houri, R., Givol, D. and Oren, M. (1984) Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J., 3, 2179-2183.
26. Vogelstein, B. and Kinzler, K.W. (1992) p53 function and dysfunction. Cell, 70, 523-526.
27. Frebourg, T., Sadelain, M., Ng, Y.S., Kassel, J. and Friend, S.H. (1994) Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype. Cancer Res., 54, 878-881.
28. Spruck, C.R., Ohneseit, P.F., Gonzalez-Zulueta, M. et al. (1994) Two molecular pathways to transitional cell carcinoma of the bladder. Cancer Res., 54, 784-788.
29. Ogawa, K., Uzvolgyi, E., St John, M.K., de Oliveira, M.L., Arnold, L. and Cohen, S.M. (1998) Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in B6D2F1 mice. Mol. Carcinogen., 21, 70-79.