Activity profiles of antimutagens: In vitro and in vivo data

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 350, Issue 1, 1996, Pages 109-129

  Waters, Michael D ^a   Stack, H Frank ^b   Jackson, Marcus A ^b   Brockman, Herman E ^c   De Flora, Silvio ^d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c ILLINOIS STATE UNIVERSITY   (United States)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Aflatoxin B1; Antimutagenicity profile; Benzo a pyrene; Chlorophyllin; Food pyrolysates or heterocyclic amine; Mechanisms; Metabolism; N Acetylcysteine; Polycyclic aromatic hydrocarbon; Retinoid; Retinol

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ACETYLCYSTEINE; ACRIDINE MUSTARD; AFLATOXIN B1; ALKYLATING AGENT; AMINOACRIDINE; ANTIMUTAGENIC AGENT; BENZO[A]PYRENE; BUSULFAN; CAFFEINE; CHLOROPHYLL; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; DOXORUBICIN; ETHIDIUM BROMIDE; HETEROCYCLIC AMINE; MELPHALAN; MEPACRINE; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; METHYLNITRONITROSOGUANIDINE; MITOMYCIN; NITROSAMINE; POLYCYCLIC AROMATIC HYDROCARBON; PROMUTAGEN; RETINOID; RETINOL; STYRENE; THIOTEPA;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; IN VITRO STUDY; IN VIVO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTECTION;

EID: 0030030415     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00097-6     Document Type: Conference Paper

References (116)

1. Ames, B.N. (1983) Dietary carcinogens and anticarcinogens, Science, 221, 1256-1264.
2. Arimoto, S. and Hayatsu, H. (1989) Role of hemin in the inhibition of mutagenic activity of 3-amino-1-methyl-5H-pyrido[4,3,b]indole (Trp-P-2) and other aminoazaarenes, Mutation Res., 213, 217-226.
3. Arimoto, S., Negishik, T. and Hayatsu, H. (1980a) Inhibitory effect of hemin on the mutagenic activities of cacinogens, Cancer Lett., 11, 29-33.
4. Arimoto, S., Ohara, Y., Namba, T., Negishi, T. and Hayatsu, H. (1980b) Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments, Biochem. Biophys. Res. Commun., 92, 662-668.
5. Arimoto, S., Fukuoka, S., Itome, C., Nakano, H., Rai, H. and Hayatsu, H. (1993) Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity, Mutation Res., 287, 293-305.
6. Athar, M.A., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R. and Mukhtar, H. (1991) All-trans retinoic acid protects against conversion of chemically induced and ultraviolet B radiation-induced skin papillomas to carcinomas. Carcinogenesis, 12, 2325-2329.
7. Ayalogu, E.O., Phillipson, C.E., Preece, N., Ioannides, C. and Parke, D.V. (1988) Effect of vitamin A on rat hepatic mixed-function oxidases, glutathione transferase activity and generations of oxygen radicals, Ann. Nutr. Metab., 32, 75-82.
8. Baird, M.B. and Birnbaum, L.S. (1979) Inhibition of 2-fluorenamine-induced mutagenesis in Salmonella typhimurium by vitamin A, J. Natl. Cancer Inst., 63, 1093-1096.
9. Balansky, R.B., D'Agostini, F., Zanacchi, P. and De Flora, S. (1992) Protection by N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke, Cancer Lett., 64, 123-131.
10. Balbinder, E., Stick, S.M. and Sharma, O.K. (1983) Complex effects of retinol on the metabolic activation of 2-aminofluorene, Environ. Mutagen., 5, 665-678.
11. Barale, R., Zucconi, D., Bertani, R. and Loprieno, N. (1983) Vegetables inhibit, in vivo, the mutagenicity of nitrite combined with nitrosable compounds, Mutation Res., 120, 145-150.
12. 1 in vitro. Carcinogenesis, 5, 1359-1362.
13. 1: In vitro effect of vitamins, Mutation Res., 188, 121-128.
14. Brockman, H.E., Stack, H.F. and Waters, M.D. (1992) Antimutagenicity profiles of some natural substances, Mutation Res., 267, 157-172.
15. Bronzetti, G., Galli, A. and Della Croce, C. (1990) Antimutagenic effect of chlorophyllin. in: Y. Kuroda, D.M. Shankel and M.D. Waters (Eds.), Antimutagenesis and Anticarcinogenesis Mechanisms II. Plenum Press, New York, pp. 463-468.
16. Budroe, J.D., Schol, H.M., Shaddock, J.G. and Casciano, D.A. (1988) Inhibition of 7,12-dimethylbenz[a]anthracene-induced genotoxicity in Chinese hamster ovary cells by retinol and retinoic acid, Carcinogenesis, 9, 1307-1311.
17. Budroe, J.D., Shaddock, J.G. and Casciano, D.A. (1987) Modulation of ultraviolet light-, ethyl methanesulfonate-, and 7,12-dimethylbenz[a]anthracene-induced unscheduled DNA synthesis by retinol and retinoic acid in the primary rat hepatocyte, Environ. Mol. Mutagen., 10, 129-139.
18. 1, Toxicol. Lett., 6, 243-249.
19. Busk, L. and Ahlborg, U.G. (1982a) Retinol (vitamin A) as a modifier of 2-aminofluorene and 2-acetyl-aminofluorene mutagenesis in the Salmonella/microsome assay, Arch. Toxicol., 49, 169-174.
20. Busk, L. and Ahlborg, U.G. (1982b) Retinoids as inhibitors of ortho-aminoazotoluene-induced mutagenesis in the Salmonella/liver microsome test, Mutation Res., 104, 225-231.
21. Busk, L., Ahlborg, U.G. and Albanus, L. (1982) Inhibition of protein pyrolysate mutagenicity by retinol (vitamin A), Food Chem. Toxicol., 20, 535-539.
22. Busk, L., Sjostrom, B. and Ahlborg, U.G. (1984) Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test), Food Chem. Toxicol., 22, 725-730.
23. Calle, L.M. and Sullivan, P.D. (1982) Screening of antioxidants and other compounds for antimutagenic properties towards benzo[a]pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium, Mutation Res., 101, 99-114.
24. Camoirano, A., Badolati, G.S., Zanacchi, P., Bagnasco, M. and De Flora, S. (1988) Dual role of thiols in N-methyl-N′-nitro-N-nitrosoguanidine genotoxicity, Life Sci. Adv. Exp. Oncol., 7, 21-25.
25. Cesarone, C.F., Scarabelli, L., Orunesu, M., Bagnasco, M. and De Flora, S. (1987) Effects of aminothiols in 2-acetylaminofluorene-treated rats. I. Damage and repair of liver DNA, hyperplastic foci, and Zymbal gland tumors, in vivo, 1, 85-91.
26. Clarke, C.H. and Shankel, D.M. (1989) Antimutagenic specificity against spontaneous and nitrofurazone-induced mutations in Escherichia coli K12ND160, Mutagenesis. 4, 31-34.
27. Cozzi, R., Bona, R., Polani, S. and De Salvia, R. (1990) Retinoids as modulators of metabolism: their inhibitory effect on cyclophosphamide and 7.12-dimethylbenz[a]anthracene induced sister chromatid exchanges in a metabolically competent cell line, Mutagenesis, 5, 397-401.
28. Darwiche, N., Celli, G., Sly, L., Lancilloti, F. and De-Luca, L.M. (1993) Retinoid status controls the appearance of reserve cells and keratin expression in mouse cervical epithelium, Cancer Res., 53, 2287-2299.
29. Dashwood, R. and Guo, D. (1992) Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation, Carcinogenesis, 13, 1121-1126.
30. Dashwood, R. and Guo, D. (1993) Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes, Environ. Mol. Mutagen., 22, 164-171.
31. Dashwood, R.H. (1992) Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA, Carcinogenesis, 13, 113-118.
32. 1 and two heterocyclic amines in the Salmonella mutagenicity assay, Carcinogenesis, 12, 939-942.
33. 1, Mutation Res., 269, 269-278.
34. De Flora, S. (1978) Metabolic deactivation of mutagens in the Salmonella/microsome test, Nature, 271, 455-456.
35. De Flora, S. (1984) Detoxication of mutagens as a threshold mechanism limiting their carcinogenicity, Toxicol. Pathol., 12, 337-343.
36. De Flora, S. (1985) Possible thresholds in genotoxicity and carcinogenicity resulting from detoxication mechanisms, Ann. Am. Conf. Ind. Hyg., 12, 145.
37. De Flora, S., Astengo, M., Serra, D. and Bennicelli, C. (1986) Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine, Cancer Lett., 32, 235-241.
38. De Flora, S., Bennicelli, C., Camoirano, A., Serra, D., Basso, C., Zanacchi, P. and Cesarone, C.F. (1987) Inhibition of mutagenesis and carcinogenesis by N-acetylcysteine, in: P.A. Cerutti, O. Nygaard and M.G. Simic (Eds.), Anticarcinogenesis and Radiation Protection. Plenum Press, New York, pp. 373-379.
39. De Flora, S., Bennicelli, C., Camoirano, A., Serra, D., Romano, M., Rossi, G.A., Morelli, A. and De Flora, A. (1985) In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds, Carcinogenesis, 6, 1735-1745.
40. De Flora, S., Bennicelli, C., Serra, D., Izzotti, A. and Cesarone, C.F. (1989) Role of glutathione and N-acetylcysteine as inhibitors ofmutagenesis and carcinogenesis, in: M. Friedman (Ed.), Absorption and Utilization of Amino Acids, Vol. III. CRC Press, Boca Raton, FL, pp. 19-53.
41. De Flora, S., Bennicelli, C., Zanacchi, P., Camoirano, A., Morelli, A. and De Flora, A. (1984a) In vitro effects of N-acetylcysteine on the mutagenicity of direct-acting compounds and procarcinogens, Carcinogenesis, 5, 505-510.
42. De Flora, S., Bianchi, V. and Levis, A.G. (1984b) Distinctive mechanisms for interaction of hexavalent and trivalent chromium with DNA?, Toxicol. Environ. Chem., 8, 287-294.
43. De Flora, S., Camoirano, A., Izzotti, A., Zanacchi, P., Bagnasco, M. and Cesarone, C.F. (1991a) Antimutagenic and anticarcinogenic mechanisms of aminothiols, in: O.F. Nygaard and A.C. Upton (Eds.), Anticarcinogenesis and Radiation Protection, Vol. 2. Plenum Press, New York, pp. 275-285.
44. De Flora, S., D'Agostini, F., Izzotti, A. and Balansky, R. (1991b) Prevention by N-acetylcysteine of benzo[a]pyrene clastogenicity and DNA adducts in rats, Mutation Res., 250, 87-93.
45. De Flora, S. and Ramel, C. (1988) Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview, Mutation Res., 202, 285-306.
46. De Flora, S., Rosenkranz, H.S. and Klopman, G. (1994) Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium, Mutagenesis, 9, 39-45.
47. De-Luca, L.M., Shores, R.L., Spangler, E.F. and Wenk, M.L. (1989) Inhibition of initiator-induced skin tumorigensis in female SENCAR mice fed a vitamin A-deficient diet and reappearance of tumors in mice fed a diet adequate in retinoid or beta-carotene, Cancer Res., 49, 5400-5406.
48. Denning, M.F. and Verma, A.K. (1994) The mechanism of the inhibition of squamous differentiation of rat tracheal 2C5 cells by retinoic acid, Carcinogenesis, 15, 503-507.
49. Dozi-Vassiliades, J., Myrtsiotis, A., Granitsas, A. and Mourelatos, D. (1985) Induction of sister-chromatid exchanges and cell-cycle delays in human lymphocytes by vitamin A alone or in combination with melphalan and caffeine. Eur. J. Cancer Clin, Eur. J. Cancer Clin. Oncol., 21, 1089-1092.
50. Ehrenberg, L., Harms-Ringdahl, M. and Granath, F. (1989) Kinetics of the copper- and iron-catalysed oxidation of cysteine by dioxygen, Acta Chem. Scand., 43, 177-187.
51. Elias, R., De Meo, M., Vidal-Ollivier, E., Laget, M., Balansard, G. and Dumenil, G. (1990) Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L, Mutagenesis, 5, 327-331.
52. Gentile, J.M. and Gentile, G.J. (1991) The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll-containing plant extracts: the relationship between mutagenicity and antimutagenicity, Mutation Res., 250, 79-86.
53. Ghosh, A., Sen, S., Sharma, A. and Talukder, G. (1991a) Inhibition of clastogenic effects of cesium chloride in mice in vivo by chlorophyllin, Toxicol. Lett., 57, 11-17.
54. Ghosh, A.K., Sen, S., Sharma, A. and Talukder, G. (1991b) Effect of chlorophyllin on mercuric chloride-induced clastogenicity in mice, Food Chem. Toxicol., 29, 777-779.
55. Gozukara, E.M., Guengerich, F.P., Miller, H. and Gelboin, H.V. (1982) Different patterns of benzo[a]pyrene metabolism of purified cytochrome P-450 from methylcholanthrene, β-naphthoflavone and phenobarbital treated rats, Carcinogenesis, 3, 129-133.
56. Grubbs, C.J., Eto, I., Juliana, M.M., Hardin, J.M. and Whitaker, L.M. (1990) Effect of retinyl acetate and 4-hydroxyphenylretinamide on initiation of chemically-induced mammary tumors, Anticancer Res., 10, 661-666.
57. Guengerich, F.P. (1988) Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy, Cancer Res., 48, 2946-2954.
58. Guo, D., Horio, D. and Dashwood, R. (1994) Inhibition and enhancement of carcinogenesis in rats given chorophyllin and 2-amino-3-methylimidazo[4,5-f]quinoline, Genet. Soc. Can. Bull., 25, 28.
59. Hartman, P.E. and Shankel, D.M. (1990) Antimutagens and anticarcinogenes: A survey of putative interceptor molecules, Environ. Mol. Mutagen., 15, 145-182.
60. Hayatsu, H., Arimoto, S. and Negishi, T. (1988) Dietary inhibitors of mutagenesis and carcinogenesis, Mutation Res., 202, 429-446.
61. Huang, C.C. (1987) Retinol (vitamin A) inhibition of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) induced sister-chromatid exchanges in V79 cells and mutations in Salmonella/microsome assay, Mutation Res., 187, 133-140.
62. 1 in Chinese hamster V79 cells, Carcinogenesis, 3, 1-5.
63. Ioannides, C., Ayrton, A.D., Keele, A., Lewis, D.F.V., Flatt, P.R. and Walker, R. (1990) Mechanism of the in vitro antimutagenic action of retinol, Mutagenesis, 5, 257-262.
64. Izzotti, A., Balansky, R.M., Coscia, N., Scatolini, L., D'Agostini, F. and De Flora, S. (1992) Chemoprevention of smoke-related DNA adduct formation in rat lung and heart, Carcinogenesis, 13, 2187-2190.
65. Izzotti, A., D'Agostini, F., Bagnasco, M., Scatolini, L., Rovida, A., Balansky, R.M., Cesarone, C.F. and De Flora, S. (1994) Chemoprevention of carcinogen-DNA adducts and chronic degenerative diseases, Cancer Res., 54, 1994s-1998s.
66. Jefcoate, C.R., Critou, M., Keller, G.M., Turner, C.R. and Wilson, N.M. (1983) A kinetic approach to polycyclic hydrocarbon activation in: J. Rystrom et al. (Eds.), Extrahepatic Drug Metabolism and Chemical Carcinogenesis. Elsevier, New York, pp. 449-458.
67. Kappus, H. (1986) Overview of enzyme systems involved in bioreduction of drugs and in redox cycling, Biochem. Pharmacol., 35, 1-6.
68. Katoh, Y., Nemoto, N., Tanaka, M. and Takayama, S. (1983) Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79 cells by hemin and related compounds, Mutation Res., 121, 153-157.
69. Kimm, S.-W. and Park, S.-C. (1982) Evidence for the existence of antimutagenic factors in edible plants, Korean J. Biochem., 14, 47-59.
70. Kimm, S.-W., Park, S.-C. and Kang, S.-J. (1982) Antimutagenic activity of chlorophyll to direct- and indirect-acting mutagens and its contents in the vegetables, Korean J. Biochem., 14, 1-8.
71. Lai, C.-N. (1979) Chlorophyll: the active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro, Nutr. Cancer, 1, 19-21.
72. Lai, C.-N., Butler, M.A. and Matney, T.S. (1980) Antimutagenic activity of common vegetables and their chlorophyll content, Mutation Res., 77, 245-250.
73. Leo, M.A. and Lieber, C.S. (1985) New pathway for retinol metabolism in liver microsomes, J. Biol. Chem., 260, 5228-5231.
74. Lowe, N.J. (1986) Topical retinoids: in vivo predictive assays, J. Am. Acad. Dermatol., 15, 766-772.
75. Malaveille, C., Kuroki, T., Sims, P., Grover, P.L. and Bartsch, H. (1977) Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells, Mutation Res., 44, 313-326.
76. Margison, G.P. and O'Connor, P.J. (1979) Nucleic acid modification by N-nitroso compounds, in: P.L. Grover (Ed.), Chemical Carcinogens and DNA, Vol. 1, CRC Press, Boca Raton, FL, pp. 111-159.
77. McCarthy, D.J., Lindamood III, C. and Hill, D.L. (1987) Effectsf of retinoids on metabolizing enzymes and on binding of benzo[a]pyrene in rat tissue DNA, Cancer Res., 47, 5014-5020.
78. McCormick, D.L., Burns, F.J. and Albert, R.E. (1980) Inhibition of rat mammary carcinogenesis by short dietary exposure to retinyl acetate, Cancer Res., 40, 1140-1143.
79. McCormick, D.L., Burns, F.J. and Albert, R.E. (1981) Inhibition of benzo[a]pyrene-induced mammary carcinogenesis by retinyl acetate, J. Natl. Cancer Inst., 66, 559-564.
80. Merriman, R.L. and Bertram, J.S. (1979) Reversible inhibition by retinoids of 3-methylcholanthrene-induced neoplastic transformation in C3H/10T1/2 clone 8 cells, Cancer Res., 39, 1661-1666.
81. Moldeus, P., Cotgreave, I.A. and Berggren, M. (1986) Lung protection by a thiol-containing antioxidant: N-acetylcysteine, Respiration, 50, 31-42.
82. Negishi, T., Arimoto, S., Nishizaki, C. and Hayatsu, H. (1989) Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), Carcinogenesis, 10, 145-149.
83. Novick, A. and Szilard, L. (1952) Anti-mutagens, Nature, 170, 926-927.
84. Ong, T.-M., Whong, W.-Z., Stewart, J. and Brockman, H.E. (1986) Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutation Res., 173, 111-115.
85. Ong, T.-M., Whong, W.-Z., Stewart, J. and Brockman, H.E. (1989) Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98, Mutation Res., 222, 19-25.
86. Owens, R.A. and Hartman, P.E. (1986) Glutathione: a protective agent in Salmonella typhimurium and Escherichia coli as measured by mutagenicity and by growth delay assays, Environ. Mutagen., 8, 659-673.
87. Parke, D.V., Ioannides, C. and Lewis, D.F.V. (1991) The 1990 Pharmaceutical manufacturers association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals, Can. J. Physiol. Pharmacol., 69, 537-549.
88. Qin, S., Batt, T. and Huang, C.C. (1985) Influence of retinol on carcinogen-induced sister chromatid exchanges and chromosome aberrations in V79 cells, Environ. Mutagen., 7, 137-146.
89. Qin, S. and Huang, C.C. (1985) Effect of retinoids on carcinogen-induced mutagenesis in Salmonella tester strains, Mutation Res., 142, 115-120.
90. 1-induced mutagenesis in Salmonella typhimurium TA-98 and TA-100, Teratogen. Carcinogen. Mutagen., 5, 29-40.
91. Ramel, C., Alekperov, U.K., Ames, B.N., Kada, T. and Wattenberg, L.W. (1986) Inhibitors of mutagenesis and their relevance to carcinogenesis, Mutation Res., 168, 47-65.
92. Renner, H.W. (1985) Anticlastogenic effect of β-carotene in Chinese hamsters, Time and dose response studies with different mutagens, Mutation Res., 144, 251-256.
93. Renner, H.W. (1990) In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations, Mutation Res., 244, 185-188.
94. Roberts, A.B. and Sporn, M.B. (1984) Cellular biology and biochemistry of the retinoids, in: M.B. Sporn, A.B. Roberts and D.W. Goodman (Eds.), The Retinoids, Vol. 2. Academic Press, Orlando, FL, pp. 209-286.
95. Romert, L., Curvall, M. and Jenssen, D. (1992) Chlorophyllin is both a positive and negative modifier of mutagenicity, Mutagenesis, 7, 349-355.
96. Romert, L. and Jenssen, D. (1987) Mechanism of N-acetylcysteine (NAC) and other thiols as both positive and negative modifiers on MNNG-induced mutagenicity in V79 Chinese hamster cells, Carcinogenesis, 8, 1531-1535.
97. Rozman, K., Gorski, J.R., Dutton, D. and Parkinson, A. (1987) Effects of vitamin A and/or thyroidectomy on liver microsomal enzymes and their induction of 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats, Toxicology, 46, 107-117.
98. Sarkar, D., Sharma, A. and Talukder, G. (1993) Differential protection of chlorophyllin against clastogenic effects of chromium and chlordane in mouse bone marrow in vivo, Mutation Res., 301, 33-38.
99. Sato, M., Imal, K., Kimura, R. and Murata, T. (1984) Effect of sodium copper chlorophyllin on lipid peroxidation, VI. Effects of its administration on mitochondria and microsomal lipid peroxidation in rat liver, Chem. Pharm. Bull., 32, 715-722.
100. 1: in vitro effect of sulphur-containing amino acids, Mutation Res., 222, 403-407.
101. Sirianni, S.R., Chen, H.H. and Huang, C.C. (1981) Effect of retinoids on plating efficiency, sister-chromatid exchange (SCE) and mitomycin-C-induced SCE in cultured Chinese hamster cells, Mutation Res., 90, 175-182.
102. Sporn, M.B. and Roberts, A.R. (1983) Role of retinoids in differentiation and carcinogenesis, Cancer Res., 43, 3034-3040.
103. Terwel, L. and van der Hoeven, J.C.M. (1985) Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in the Salmonella/microsome assay, Mutation Res., 152, 1-4.
104. Verma, A.K., Inhibition of both stage I and stage II mouse skin tumor promotion by retinoic acid and the dependence of inhibition of tumor promotion on the duration of retinoic acid treatment, Cancer Res., 47, 5097-5101.
105. Warner, J.R., Nath, J. and Ong, T.-M. (1991) Antimutagenicity studies of chlorophyllin using the Salmonella arabinose-resistant assay system, Mutation Res., 262, 25-30.
106. Waters, M.D., Stack, H.F., Brady, A.L., Lohman, P.H.M., Haroun, L. and Vainio, H. (1988) Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds, Mutation Res., 205, 295-312.
107. Wattenberg, L.W. (1985) Chemoprevention of cancer, Cancer Res., 45, 1-8.
108. Wattenberg, L.W., Hochalter, J.B., Prabhu, U.D.G. and Galbraith, A.R. (1987) Nucleophiles as anticarcinogens, in: P. Cerutti, M.G. Simic and O.F. Nygaard (Eds.), Anticarcinogenesis and Radiation Protection. Plenum Press, New York, pp. 233-240.
109. 1-induced reversion in Salmonella typhimurium strain TA98, Teratogen. Carcinogen. Mutagen., 8, 215-224.
110. Wilpart, M., Mainguet, P., Geeroms, D. and Roherfroid, M. (1985) Desmutagenic effects of N-acetylcysteine on direct and indirect mutagens, Mutation Res., 142, 169-177.
111. Wilpart, M., Speder, A. and Roberfroid, M. (1986) Anti-initiation activity of N-acetylcysteine in experimental colonie carcinogenesis, Cancer Lett., 31, 319-324.
112. Wislocki, P.G., Wood, A.W., Chang, R.L., Levin, W., Conney, A.H., Yagi, H., Hernandez, O., Jerina, D.M. and Conney, A.H. (1976b) High mutagenicity and toxicity of diol epoxide derived from benzo[a]pyrene, Biochem. Biophys. Res. Commun., 68, 1006-1012.
113. Wislocki, P.G., Wood, A.W., Chang, R.L., Levin, W., Yagi, H., Hernandez, O., Dansette, P.M., Jerina, D.M. and Conney, A.H. (1976a) Mutagenicity and cytotoxicity of benzo[a]pyrene arene oxides, phenols, quinones and dihydrodiols in bacterial and mammalian cells, Cancer Res., 36, 3350-3357.
114. Wood, A.W., Chang, R.L., Levin, W., Yagi, H., Thakker, D.R., Jerina, D.M. and Conney, A.H. (1977) Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9-10-epoxides, Biochem. Biophys. Res. Commun., 77, 1389-1396.
115. Yang, C.S., Brady, J.F. and Hong, J.-Y. (1992) Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity, FASEB J., 6, 737-744.
116. Zile, M.H., Cullum, M.E., Roltsch, I.A., DeHoog, J.V. and Welsch, C.W. (1986) Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz[a]anthracene, Cancer Res., 46, 3495-3503.