Metal complexes as allosteric effectors of human hemoglobin: An NMR study of the interaction of the gadolinium(III) bis(m- boroxyphenylamide)diethylenetriaminepentaacetic acid complex with human oxygenated and deoxygenated hemoglobin

Biophysical Journal

Volumn 76, Issue 5, 1999, Pages 2735-2743

  Aime, Silvio ^a   Digilio, Giuseppe ^a   Fasano, Mauro ^a   Paoletti, Silvia ^a   Arnelli, Aldo ^b   Ascenzi, Paolo ^c  

^a UNIVERSITY OF TURIN   (Italy)

^b Ospedale Civile USL 61   (Italy)

^c ROMA TRE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRAST MEDIUM; GADOLINIUM PENTETATE; HEMOGLOBIN;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; COMPLEX FORMATION; DISSOCIATION CONSTANT; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXYGEN AFFINITY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0032988667     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77426-6     Document Type: Article

References (37)

1. Abraham, D. J., M. K. Safo, T. Boyiri, R. E. Danso-Danquah, J. Kister, and C. Poyart. 1995. How allosteric effectors can bind to the same protein residue and produce opposite shifts in the allosteric equilibrium. Biochemistry. 34:15006-15020.
2. Aime, S., P. Ascenzi, E. Comoglio, M. Fasano, and S. Paoletti. 1995a. Molecular recognition of R and T forms of human hemoglobin by a paramagnetic Gd(III) complex by means of the measurement of solvent water proton relaxation rate. J. Am. Chem. Soc. 117:9365-9366.
3. 1H-NMR relaxometric investigation of bis(benzylamide)DTPA complex. Inorg. Chim. Acta. 254:63-70.
4. Aime, S., M. Botta, W. Dastrù, M. Fasano, M. Panero, and A. Arnelli. 1993a. Synthesis and characterization of a novel DTPA-like gadolinium(III) complex: a potential reagent for the determination of glycated proteins by water proton NMR relaxation measurements. Inorg. Chem. 32:2068-2071.
5. Aime, S., M. Botta, M. Fasano, S. Geninatti Crich, and E. Terreno. 1996a. Gd(III) complexes as contrast agents for magnetic resonance imaging. A proton relaxation enhancement study of the interaction with human serum albumin. J. Biol. Inorg. Chem. 1:312-319.
6. Aime, S., M. Botta, M. Fasano, S. Paoletti, P. L. Anelli, F. Uggeri, and M. Virtuani. 1994. NMR evidence of a long exchange lifetime of the coordinated water in Ln(III) bis methyl amide DTPA complexes (Ln = Gd, Dy). Inorg. Chem. 33:4707-4711.
7. Aime, S., M. Botta, M. Fasano, and E. Terreno. 1993b. Paramagnetic Gd(III)-Fe(III) heterobimetallic complexes of DTPA-bis-salicylamide. Spectrochim. Acta. 49A:1315-1322.
8. Aime, S., M. Fasano, S. Paoletti, and E. Terreno. 1995b. Towards novel non-ionic contrast agents for magnetic resonance imaging: synthesis and characterization of [(bisphenylamide-DTPA)M(III)] complexes (M = Lu, Y and Gd). Gazz. Chim. Ital. 125:125-131.
9. Aime, S., M. Fasano, S. Paoletti, F. Viola, C. Tarricone, and P. Ascenzi. 1996b. Inhibition of serine proteinases by a bisamide boronic gadolinium complex: a thermodynamic and NMR relaxometric study. Biochem. Mol. Biol. Int. 39:741-746.
10. Antonini, E., and M. Brunori. 1971. Hemoglobin and Myoglobin in Their Reactions with Ligands. North-Holland, Amsterdam.
11. Ascenzi, P., A. Bertollini, M. Coletta, A. Desideri, B. Giardina, F. Polizio, R. Santucci, R. Scatena, and G. Amiconi. 1993. Cooperative effect of inositol hexakisphosphate, bezafibrate, and clofibric acid on the spectroscopic properties of the nitric oxide derivative of ferrous human hemoglobin. J. Inorg. Biochem. 50:263-272.
12. Baker, J., P. Metcalf, R. Scragg, and R. Johnson. 1991. Fructosamine Test-Plus, a modified fructosamine assay evaluated. Clin. Chem. 37: 552-556.
13. Band, L., I. Bertini, and C. Luchinat. 1991. Electron and Nuclear Relaxation. VCH, Weinheim.
14. Bertini, I., and C. Luchinat. 1986. NMR of Paramagnetic Molecules in Biological Systems. Benjamin-Cummings, Menlo Park, CA.
15. Boyiri, T., M. K. Safo, R. E. Danso-Danquah, J. Kister, C. Poyart, and D. J. Abraham. 1995. Bisaldehyde allosteric effectors as molecular ratchets and probes. Biochemistry. 34:15021-15036.
16. Dwek, R. A. 1973. Nuclear Magnetic Resonance in Biochemistry. Applications to Enzyme Systems. Clarendon Press, Oxford.
17. Ehnebom, L., and B. F. Pedersen. 1992. Molecular and crystal structure of a lanthanide complex, DyDTPA-BMA hydrate. Acta Chem. Scand. 46:126-130.
18. Eisinger, J., R. G. Shulman, and W. E. Blumberg. 1961. Relaxation enhancement by paramagnetic ion binding in deoxyribonucleic acid solution. Nature New Biol. 192:963-964.
19. Fermi, G., and M. F. Perutz. 1981. Atlas of Molecular Structures in Biology: Haemoglobin and Myoglobin. Clarendon Press, Oxford.
20. Geraldes, C. F. G. C., A. M. Urbano, M. C. Alpoim, A. D. Sherry, K.-T. Kuan, R. Rajagopalan, F. Maton, and R. N. Muller. 1995. Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents. Magn. Reson. Imaging. 13:401-420.
21. Geraldes, C. F. G. C., A. M. Urbano, M. A. Hoefnagel, and J. A. Peters. 1993. Multinuclear magnetic resonance study of the structure and dynamics of lanthanide (III) complexes of the bis(propylamide) of diethyienetriaminepentaacetic acid in aqueous solution. Inorg. Chem. 32: 2426-2432.
22. Koenig, S. H., and R. D. Brown, III. 1990. Field-cycling relaxometry of protein solutions and tissue: implication for MRI. Prog. Nucl. Magn. Reson. Spectrosc. 22:487-567.
23. Konings, M. S., W. C. Dow, D. B. Love, K. N. Raymond, S. C. Quay, and S. M. Rocklage. 1990. Gadolinium complexation by a new DTPA-amide ligand. Amide oxygen coordination. Inorg Chem. 29:1488-1491.
24. Lauffer, R. B. 1987. Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design. Chem. Rev. 87:901-927.
25. 3+ proteinchelate conjugates. Magn. Reson. Med. 3:541-548.
26. Lipari, G., and A. Szabo. 1982. Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity. J. Am. Chem. Soc. 104:4546-4559.
27. Mallia, A. K., G. T. Hermanson, R. I. Krohn, E. K. Fujimoto, and P. K. Smith. 1981. Preparation and use of a boronic acid affinity support for separation and quantitation of glycosylated hemoglobins. Anal. Lett. 14:649-661.
28. Mildvan, A. S., and M. Conn. 1963. Magnetic resonance studies of the interaction of the manganous ion with bovine serum albumin. Biochemistry. 2:910-919.
29. Piotto, M., V. Saudek, and V. Sklenar. 1992. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. J. Biomol. NMR. 2:661-665.
30. Quay, S. C. 1987. Patent WO 86 02,841. Chem. Abs. 106:340.
31. 2+ by diethylenetriaminepentaacetic acid bis(methylamide). Inorg. Chem. 32:582-586.
32. Russu, I. M., N. T. Ho, and C. Ho. 1987. A proton nuclear Overhauser effect investigation of the subunit interfaces in human normal adult hemoglobin. Biochim. Biophys. Acta. 914:40-48.
33. Shaanan, B. 1983. Structure of human oxyhaemoglobin at 2.1 Å resolution. J. Mol. Biol. 171:31-59.
34. Tweedle, M. F. 1989. MRI contrast agents. In Lanthanide Probes in Life, Chemical and Earth Sciences. J.-C. G. Bünzli and G. R. Choppin, editors. Elsevier, Amsterdam. 127-151.
35. Wettre, S., H. J. Arnqvist, and H. Von Schenck. 1993. Assessment of glycaemic control in non-insulin-dependent diabetes meltitus. Scand. J. Clin. Lab. Invest. 53:163-170.
36. Wyman, J. 1964. Linked functions and reciprocal effects in hemoglobin: a second look. Adv. Protein Chem. 19:223-286.
37. Zijlstra, W. G., A. Buursma, and W. P. Meeuwsen-van der Roest. 1991. Absorption spectra of human fetal and adult oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin. Clin. Chem. 37:1633-1638.