Cholesterol may act as an antioxidant in lens membranes

Current Eye Research

Volumn 18, Issue 6, 1999, Pages 448-454

  Girao, Henrique ^a   Mota, Carolina ^a   Pereira, Paulo ^a  

^a Biomed Inst Res Light and Image   (Portugal)

Author keywords

Bovine (cattle); Cataract; Cholesterol; Cholesterol oxides; Lens; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; AZO COMPOUND; CHOLESTEROL; LIPID HYDROPEROXIDE; PARINARIC ACID;

ANIMAL TISSUE; ARTICLE; CATTLE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LENS EPITHELIUM; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; AMIDINES; ANIMALS; ANTIOXIDANTS; CATTLE; CHOLESTEROL; LENS, CRYSTALLINE; LIPOSOMES; MEMBRANES; OXIDANTS; OXIDATION-REDUCTION; VITAMIN E;

EID: 0032988601     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.18.6.448.5273     Document Type: Article

References (28)

1. Piatigorsky J. Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 1981;19:134-153.
2. El-Sayed GN, Cenedella RJ. Relationship of choiesterologenesis to DNA synthesis and proliferation by lens epithelial cells in culture. Exp Eye Res. 1987;45:443-451.
3. Cenedella RJ. Cholesterol and cataracts. Surv Ophthalmol. 1996;40:320-337.
4. Smith LL, Kulig MJ, Teng JI. On the failure of superoxide radical anion to react with cholesterol. Chem Phys Lipids 1977;44:87-125.
5. Girão H, Mota MC, Ramalho J, Pereira P. Cholesterol oxides accumulate in human cataracts. Exp Eye Res. 1998;66:645-652.
6. Sadeg N, Pham H.C, Martin C. Warnet JM, Claude JR. Effect of cyclosporin A and its metabolites and analogs on lipid peroxidation in rabbit renal microsomes. Drug Chem. Toxicol. 1993;16:165-174.
7. Smith, LL, Johnson BH. Biological activities of oxysterols. Free Rad Biol Med. 1989;7:285-332.
8. Smith LL. Another cholesterol hypothesis: cholesterol as antioxidant. Free Rad Biol Med. 1991;11:47-61.
9. Parasassi T, Giusti AM, Raimondi M, Ravagnan G, Sapora O, Gratton E. Cholesterol protects the phospholipids bilayer from oxidative damage. Free Rad Biol Med. 1995;19:511-516.
10. Seligman ML, Mitamura J, Shera N, Demopoulos HB. Corticosteroids (methylprednisolone) modulation of photoperoxidation by ultraviolet light in liposomes. Photochem Photobiol. 1979;29:549-558.
11. Braugher JM, Pregenzer JF, Chase RL, Duncan LA, Jacobsen EJ, McCall JM. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J Biol Chem. 1987;262:10438-10440.
12. Braugher JM, Pregenzer JF. The 21-amino steroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. Free Radic Biol Med. 1989; 7:125-130.
13. Sugioka K, Shimosegawa Y, Nakano M. Estrogens as natural antioxidants of membrane phospholipids peoxidation. FEBS Lett. 1987;210:37-39.
14. Huber LA, Scheffler E, Poll T, Ziegler R, Dresel HA. 17 beta-estradiol inhibits LDL oxidation and cholesteryl ester formation in cultured macrophages. Free Radic Res. Commun. 1990;8:167-173.
15. Fernandes R, Pereira P, Ramalho JS, Mota MC, Oliveira CR. An experimental model for the evaluation of lipid peroxidation in lens membranes. Curr Eye Res. 1996;15:395-402.
16. Nourooz-Zadeh J. Determination of the autoxidation products rom free or total cholesterol: a new multistep enrichment methodology including the enzymatic release of esterified cholesterol. J Agric Food Chem. 1990;38:1667-1673.
17. Nourooz-Zadeh J, Tajaddini-Sarmadi J, Wolff SP. Measurements of plasma hydroperoxide concentrations by ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal Biochem. 1994;220:403-409.
18. Kuypers FA, van den Berg JJM. Schalkwijk C, Roelofsen B, Op den Kamp JAF. Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation. Biochim Biophys Acta 1987;921:266-274.
19. Barlett GR. Phosphorus assay in column chromatography. J. Biol. Chem. 1959;234:466-468.
20. Zelenka PS. Lens lipids. Curr Eye Res. 1984;3:1337-1359.
21. Halliwell B. Albumin: an important extracellular antioxidant. Biochem Pharmacol. 1988;37:569-571.
22. Eaton JW. Is the lens canned? Free Radic Biol Med. 1991;11:207-213
23. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995;9:1173-1182.
24. Garner MH, Roy D, Rosenfeld D, Garner WH, Spector A. Biochemical evidence for membrane disintegration in human cataract. Proc Nat! Acad Sci. USA 1981;78: 1892-1895.
25. Report of the Cataract Panel Vision Research: A National Plan. U.S. Department of Health and Human Services, NIH Publ. 1983-87;Vol 2, Part 3.
26. Borchman D, Cenedella RJ, Lamba OP. Role of cholesterol in the structural order of lens membrane lipids. Exp Eye Res. 1996;62:191-198.
27. Stillwell W, Dallman T, Dumaual AC, Crump FT, Jenski LJ. Cholesterol versus α-tocopherol: effects on properties of bilayers made from heteroacids phosphatidylcholines. Biochemistry 1996;35:13353-13362.
28. Parasassi T, Gratton, E. Packing of phospholipid vesicles studied by oxygen quenching of Laurdan fluorescence. J Fluorescence 1992;2:167-174.