Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 8, 1999, Pages 1738-1744

  Kawazu, Kouichi ^a   Yamada, Kazuhito ^b   Nakamura, Masatsugu ^b   Ota, Atsutoshi ^b  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; CYCLOSPORIN A; GLYCOPROTEIN P;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROTECTION; CORNEA EPITHELIUM; CORNEA TRANSPLANTATION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG TRANSPORT; EPITHELIUM CELL; EYE DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RABBIT;

3-O-METHYLGLUCOSE; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL SIZE; CELLS, CULTURED; CYCLOSPORINE; DRUG COMBINATIONS; DRUG RESISTANCE, MULTIPLE; EPITHELIUM, CORNEAL; P-GLYCOPROTEIN; PEPTIDYLPROLYL ISOMERASE; PERMEABILITY; RABBITS; SODIUM AZIDE; TEMPERATURE; TIME FACTORS;

EID: 0032987924     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Faulds D, Goa KL, Benfield P. Cyclosporin. A review of its pharmacodynamic and pharmacokinetics properties, and therapeutic use in immunoregulatory disorders. Drugs. 1993;45:953-1040.
2. Smet MD, Nussenblatt RB. Clinical use of cyclosporine in ocular disease. Int Ophthalmol Clin. 1993;33:31-45.
3. Mochizuki M, Smet M. Use of immunosuppressive agents in ocular diseasea. Prog Retinal Eye Res. 1994;13:479-506.
4. Bell TAG, Hunnisett AG. Cyclosporin A: tissue levels following topical and systemic administration to rabbits. Br J Ophthalmol. 1986;70:852-855.
5. Wiederholt M, Kössendrup D, Schulz W, et al. Pharmacokinetic of topical cyclosporin A in the rabbit eye. Invest Ophthalmol Vis Sci. 1986;27:519-524.
6. Kaswan RL. Intraocular penetration of topically applied cyclosporine. Transpl Proc. 1988;20(suppl. 2):650-655.
7. Llopis MD, Menezo JL. Penetration of 2% cyclosporin eyedrops into human aqueous humor. Br J Ophthalmol. 1989;73:600-603.
8. BenEzra D, Maftzir G. Ocular penetration of cyclosporine A in the rat eye. Arch Ophthalmol. 1990;108:584-587.
9. BenEzra D, Maftzir G. Ocular penetration of cyclosporin A: the rabbit eye. Invest Ophthalmol Vis Sci. 1990;31:1362-1366.
10. BenEzra D, Maftzir G, Courten C, et al. Ocular penetration of cyclosporin A.III: the human eye. Br J Ophthalmol. 1990;74:350-352.
11. Kanpolat A, Batioglu F, Yilmaz M, et al. Penetration of cyclosporin A into the rabbit cornea and aqueous humor after topical drop and collagen shield administration. CLAO J. 1994;20:119-122.
12. Oh C, Saville BA, Cheng YL, et al. A compartmental model for the ocular pharmacokinetics of cyclosporine in rabbits. Pharm Res. 1995;12:433-437.
13. Bonduelle S, Carrier M, Pimienta C, et al. Tissue concentration of nanoencapsulated radiolabelled cyclosporin following peroral delivery in mice or ophthalmic application in rabbits. Eur J Pharm Biopharm. 1996;42:313-319.
14. Cheeks L, Kaswan RL, Green K. Influence of vehicle and anterior chamber protein concentration on cyclosporine penetration through the isolated rabbit cornea. Curr Eye Res. 1992;11:641-649.
15. Cefalu WT, Pardrige WM. Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier. J Neurochem. 1985;45:1954-1956.
16. Thiebaut F, Tsuruo T, Hamada H, et al. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci. 1987;84:7735-7738.
17. Shimabuku AM, Nishimoto T, Ueda K, et al. P-glycoprotein. J Biol Chem. 1992;267:4308-4311.
18. Borst P, Schinkel AH, Smit JJM, et al. Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals. Pharmacol Ther. 1993;60:289-299.
19. Patel NH, Rothenberg ML. Multidrug resistance in cancer chemotherapy. Invest New Drugs. 1994;12:1-13.
20. Levéque D, Jehl F. P-glycoprotein and pharmacokinetics. Anticancer Res. 1995;15:331-336.
21. Tsuji A, Tamai I, Sakata A, et al. Restrict transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem Pharmacol. 1993;46:1096-1099.
22. Augustijns PF, Bradshaw TP, Gan LSL, et al. Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport. Biochem Biophys Res Commun. 1993;197: 360-365.
23. Okamura N, Hirai M, Tanigawara Y, et al. Digoxin-cyclosporin A interaction: modulation of the multidrug transport P-glycoprotein in the kidney. J Pharmacol Exp Ther. 1993;266:1614-1619.
24. Sakata A, Tamai I, Kawazu K, et al. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclopsporin A at the blood-brain barrier. Biochem Pharmacol. 1994;48:1989-1992.
25. Shirai A, Naito M, Tatsuta T, et al. Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. Biochimi Biophys Acta. 1994;1222:400-404.
26. Schinkel AH, Wagenaar E, Deemter L, et al. Absence of the mdrla P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest. 1995;96:1698-1705.
27. Fricker G, Drewe J, Huwyler J, et al. Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. Br J Pharmacol. 1996;118:1841-1847.
28. Tanaka K, Hirai M, Tanigawara Y, et al. Effect of cyclosporin analogues and FK506 on transcellular transport of daunrubicin and vincristine via P-glycoprotein. Pharm Res. 1996;13:1073-1077.
29. Sana P, Yang JJ, Lee VHL. Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells. Invest Ophthalmol Vis Sci. 1998;39:1221-1226.
30. Torishima H, Kinoshita S, Nezu E, et al. Serum-free serial culture and frozen storage of rabbit corneal epithelial cells. Atarashii Ganka. 1996;13:613-620.
31. Kawazu K, Shiono H, Tanioka H, et al. Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports. Curr Eye Res. 1998;17:125-131.
32. Tsuji A, Terasaki T, Takabatake Y, et al. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 1992;151:1427-1437.
33. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265-275.
34. O'Donnell ME. Role of Na-K-Cl cotransport in vasucular endothelial cell volume regulation. Am J Physiol. 1993;264:C1316-C1326.
35. Hosoya K, Kim KJ, Lee VHL. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm Res. 1996; 13:885-890.
36. Yamaoka K, Tanigawara Y, Nakagawa T, et al. A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobio-Dyn. 1981;4:875-885.
37. Merker MM, Handschumacher RE. Uptake and nature of the intracellular binding of cyclosporin A in a murine thymoma cell line, BW5147. J Immunol. 1984;132:3064-3070.
38. Fahre I, Fabre G, Lena N, et al. Kinetics of uptake and intracellular binding of cyclosporine A in RAJI cells, in vitro. Biochem Pharmacol. 1986;35:4261-4266.
39. 1). J Pharmacol Exp Ther. 1991;257:200-204.
40. Foxwell BMJ, Woerly G, Husi H, et al. Identification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vitro. Biochim Biophys Acta. 1992;1138:115-121.
41. Didier A, Wenger J, Loor F. Decreased uptake of cyclosporin A by P-glycoprotein (P-gp) expressing CEM leukemic cells and restoration of normal retention by P-gp blockers. Anti-Cancer Drugs. 1995;6:669-680.
42. Koletsky AJ, Harding MW, Handschumacher RE. Cyclophilin: distribution and variant properties in normal and neoplastic tissues. J Immunol. 1986;137:1054-1059.
43. Ryffel B, Woerly G, Greiner B, et al. Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology. 1991;72:399-404.
44. Gallo P, Saviano M, Rossi F, et al. Specific interaction between cyclophilin and cyclic peptides. Biopolymers. 1995;36:273-281.
45. Chang JE, Basu S, Lee VHL. Characterization of a primary rabbit corneal epithelial cell culture grown on permeable support [ARVO Abstracts]. Invest Ophthalmol Vis Sci. 1998;39(4):S758. Abstract nr 3497.
46. Greeenwood J. Characterization of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitro. J Neuroimmunol. 1992;39:123-132.
47. Holash JA, Stewart PA. The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers. Brain Res. 1993;629:218-224.